Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase IIβ Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity

Bisdioxopiperazine agent dexrazoxane (ICRF-187) has been the only effective and approved drug for prevention of chronic anthracycline cardiotoxicity. However, the structure-activity relationships (SARs) of its cardioprotective effects remain obscure owing to limited investigation of its derivatives/...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2020-06, Vol.373 (3), p.402-415
Hauptverfasser:	Kollárová-Brázdová, Petra, Jirkovská, Anna, Karabanovich, Galina, Pokorná, Zuzana, Bavlovič Piskáčková, Hana, Jirkovský, Eduard, Kubeš, Jan, Lenčová-Popelová, Olga, Mazurová, Yvona, Adamcová, Michaela, Skalická, Veronika, Štěrbová-Kovaříková, Petra, Roh, Jaroslav, Šimůnek, Tomáš, Štěrba, Martin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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