Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia

Paclitaxel is a commonly used cytotoxic anticancer drug with potentially life-threatening toxicity at therapeutic doses and high interindividual pharmacokinetic variability. Thus, drug and effect monitoring is indicated to control dose-limiting neutropenia. Joerger et al. (2016) developed a dose ind...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2017-08, Vol.362 (2), p.347-358
Hauptverfasser:	Henrich, Andrea, Joerger, Markus, Kraff, Stefanie, Jaehde, Ulrich, Huisinga, Wilhelm, Kloft, Charlotte, Parra-Guillen, Zinnia Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Bone Marrow - drug effects Bone Marrow - metabolism Humans Models, Biological Neutropenia - chemically induced Neutropenia - metabolism Prospective Studies
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