Morphine Glucuronidation and Glucosidation Represent Complementary Metabolic Pathways That Are Both Catalyzed by UDP-Glucuronosyltransferase 2B7: Kinetic, Inhibition, and Molecular Modeling Studies

Morphine 3-β-D-glucuronide (M3G) and morphine 6-β-D-glucuronide (M6G) are the major metabolites of morphine in humans. More recently, morphine-3-β-d-glucoside (M-3-glucoside) was identified in the urine of patients treated with morphine. Kinetic and inhibition studies using human liver microsomes (H...

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Veröffentlicht in:The Journal of pharmacology and experimental therapeutics 2014-04, Vol.349 (1), p.126-137
Hauptverfasser: Chau, Nuy, Elliot, David J., Lewis, Benjamin C., Burns, Kushari, Johnston, Martin R., Mackenzie, Peter I., Miners, John O.
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Sprache:eng
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