Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways

Anthracycline anticancer drugs (e.g., doxorubicin or daunorubicin) can induce chronic cardiotoxicity and heart failure (HF), both of which are believed to be based on oxidative injury and mitochondrial damage. In this study, molecular and functional changes induced by chronic anthracycline treatment...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2012-11, Vol.343 (2), p.468-478
Hauptverfasser:	Jirkovsky, Eduard, Popelová, Olga, Kriváková-Stanková, Pavla, Vávrová, Anna, Hroch, Milos, Hasková, Pavlína, Brcáková-Dolezelová, Eva, Micuda, Stanislav, Adamcová, Michaela, Simůnek, Tomás, Cervinková, Zuzana, Gersl, Vladimír, Sterba, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracyclines - toxicity Antibiotics, Antineoplastic - toxicity Cell Nucleus - drug effects Cell Nucleus - metabolism Daunorubicin - pharmacology Echocardiography Glutathione - metabolism Heart Diseases - chemically induced Heart Diseases - metabolism Heart Function Tests Heart Ventricles - drug effects Heart Ventricles - metabolism Lipid Peroxidation - drug effects Male Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Myocardium - pathology NF-E2-Related Factor 2 - biosynthesis Oxidative Stress - drug effects Rabbits Real-Time Polymerase Chain Reaction Survival Transcription Factors - metabolism Troponin T - metabolism
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