Pharmacodynamics and Subchronic Toxicity in Mice and Monkeys of ISIS 388626, a Second-Generation Antisense Oligonucleotide That Targets Human Sodium Glucose Cotransporter 2

ISIS 388626, a 2′-methoxyethyl (MOE)-modified antisense oligonucleotide (ASO) that targets human sodium glucose cotransporter 2 (SGLT2) mRNA, is in clinical trials for the management of diabetes. SGLT2 plays a pivotal role in renal glucose reabsorption, and inhibition of SGLT2 is anticipated to redu...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2012-11, Vol.343 (2), p.489-496
Hauptverfasser:	Zanardi, Thomas A., Han, Su-Cheol, Jeong, Eun Ju, Rime, Soyub, Yu, Rosie Z., Chakravarty, Kaushik, Henry, Scott P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antisense oligonucleotide Area Under Curve area under the curve ASO AUC below the lower limit of quantitation BLQ Chemistry, Pharmaceutical coefficient of variation Dose-Response Relationship, Drug Electrocardiography - drug effects Female Half-Life Hemodynamics - drug effects Injections, Subcutaneous Kidney - drug effects Kidney - metabolism Korea Institute of Toxicology Macaca fascicularis Male methoxyethyl Mice Mice, Inbred ICR MOE Oligodeoxyribonucleotides - pharmacokinetics Oligodeoxyribonucleotides - pharmacology Oligodeoxyribonucleotides - toxicity Oligonucleotides, Antisense - pharmacokinetics Oligonucleotides, Antisense - pharmacology Oligonucleotides, Antisense - toxicity Pharmacokinetics RNA, Messenger - biosynthesis RNA, Messenger - genetics SGLT sodium glucose cotransporter Sodium-Glucose Transporter 2 - antagonists & inhibitors
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