Immunophyllin Ligands Show Differential Effects on Alcohol Self-Administration in C57BL Mice

High abstinence rates characterize alcohol-dependent liver graft recipients. The immunosuppressants cyclosporine A (CsA) and tacrolimus (TRL) also inhibit calcineurin (CLN) in the brain. Previously, we found that CsA reduces alcohol consumption in C57BL/6J mice. The goals of the present study were:...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2012-06, Vol.341 (3), p.611-616
Hauptverfasser:	Beresford, Thomas, Fay, Tina, Serkova, Natalie J., Wu, Peter H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - drug therapy Animals Behavioral Pharmacology Brain - drug effects Brain - metabolism Calcineurin - drug effects Cyclosporine - pharmacology Dose-Response Relationship, Drug Drug Interactions Ethanol Immunosuppressive Agents - pharmacology Ligands Male Mice Mice, Inbred C57BL Self Administration Sirolimus - pharmacology Sucrose - administration & dosage Tacrolimus - pharmacology
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