Effects of chlorpyrifos and chlorpyrifos-oxon on the dynamics and movement of mitochondria in rat cortical neurons

Organophosphate (OP)-based pesticides have been used extensively for decades, and as a result, they have become almost ubiquitous in our environment. There is clinical and animal evidence to suggest that chronic exposures to OPs can lead to cognitive dysfunction and other neurological abnormalities,...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2011-11, Vol.339 (2), p.341-349
Hauptverfasser:	Middlemore-Risher, Mary-Louise, Adam, Bao-Ling, Lambert, Nevin A, Terry, Jr, Alvin V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Adenosine Triphosphate - biosynthesis Adenosine Triphosphate - metabolism Animals Axonal Transport - drug effects Axons - drug effects Cell Movement - drug effects Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - physiology Chlorpyrifos - analogs & derivatives Chlorpyrifos - toxicity Cholinesterase Inhibitors - toxicity Dose-Response Relationship, Drug GPI-Linked Proteins - antagonists & inhibitors Insecticides - pharmacology Insecticides - toxicity Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Mitochondria - physiology Neurons - drug effects Nicotinic Antagonists - pharmacology Rats Rats, Sprague-Dawley Receptors, Cholinergic - metabolism Superoxides - metabolism
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