Nociceptin/Orphanin FQ Peptide Receptor Agonist Ac-RYYRWKKKKKKK-NH2 (ZP120) Induces Antinatriuresis in Rats by Stimulation of Amiloride-Sensitive Sodium Reabsorption

The aim of the present study was to examine the mechanisms responsible for the antinatriuretic effect of the selective, peripherally acting, nociceptin/orphanin FQ peptide (NOP) receptor partial agonist Ac-RYYRWKKKKKKK-NH2 (ZP120). Using immunohistochemistry, we showed that in the cortex NOP recepto...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2009-02, Vol.328 (2), p.533-539
Hauptverfasser:	van Deurs, Ulla S.K., Hadrup, Niels, Petersen, Jørgen Søberg, Christensen, Sten, Jonassen, Thomas E.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption - drug effects Absorption - physiology Amiloride - pharmacology Animals Drug Interactions Immunohistochemistry Natriuresis - drug effects Natriuresis - physiology Nociceptin Nociceptin Receptor Oligopeptides - pharmacology Opioid Peptides - pharmacology Rats Rats, Wistar Receptors, Opioid - agonists Sodium - metabolism
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