Tertiary Oxidation of Deoxycholate Is Predictive of CYP3A Activity in Dogs

Deoxycholic acid (DCA, 3 , 12 -dihydroxy-5 -cholan-24-oic acid) is the major circulating secondary bile acid, which is synthesized by gut flora in the lower gut and selectively oxidized by CYP3A into tertiary metabolites, including 1 ,3 ,12 -trihydroxy-5 -cholan-24-oic acid (DCA-1 -ol) and 3 ,5 ,12...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Drug metabolism and disposition 2021-05, Vol.49 (5), p.369-378
Hauptverfasser:	Zeng, Wushuang, Gui, Lanlan, Tan, Xianwen, Zhu, Pingping, Hu, Yiting, Wu, Qingliang, Li, Xuejing, Yang, Lian, Jia, Wei, Liu, Changxiao, Lan, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A Inhibitors - metabolism Cytochrome P-450 CYP3A Inhibitors - pharmacology Deoxycholic Acid - metabolism Dogs Enzyme Activation - drug effects Enzyme Activation - physiology Female Forecasting GABA Modulators - metabolism GABA Modulators - pharmacology Humans Ketoconazole - metabolism Ketoconazole - pharmacology Male Microsomes, Liver - drug effects Microsomes, Liver - metabolism Midazolam - metabolism Midazolam - pharmacology Oxidation-Reduction - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!