Evaluation of Tissue Binding in Three Tissues across Five Species and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding with an Existing Model

Volume of distribution (Vd) is a primary pharmacokinetic parameter used to calculate the half-life and plasma concentration-time profile of drugs. Numerous models have been relatively successful in predicting Vd, but the model developed by Korzekwa and Nagar is of particular interest because it util...

Ausführliche Beschreibung