Application of Azamulin to Determine the Contribution of CYP3A4/5 to Drug Metabolic Clearance Using Human Hepatocytes

Early determination of CYP3A4/5 contribution to the clearance of new chemical entities is critical to inform on the risk of drug-drug interactions with CYP3A inhibitors and inducers. Several in vitro approaches (recombinant P450 enzymes, correlation analysis, chemical and antibody inhibition in huma...

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Veröffentlicht in:	Drug metabolism and disposition 2020-09, Vol.48 (9), p.778-787
Hauptverfasser:	Chanteux, Hugues, Rosa, Maria, Delatour, Claude, Nicolaï, Johan, Gillent, Eric, Dell’Aiera, Sylvie, Ungell, Anna-Lena
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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