Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models

A great deal of effort has been being made to improve the accuracy of the prediction of drug-drug interactions (DDIs). In this study, we addressed CYP3A-mediated weak DDIs, in which a relatively high false prediction rate was pointed out. We selected 17 orally administered drugs that have been repor...

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Veröffentlicht in:	Drug metabolism and disposition 2020-04, Vol.48 (4), p.288-296
Hauptverfasser:	Yamada, Makiko, Inoue, Shin-ichi, Sugiyama, Daisuke, Nishiya, Yumi, Ishizuka, Tomoko, Watanabe, Akiko, Watanabe, Kengo, Yamashita, Shinji, Watanabe, Nobuaki
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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