Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life

Human hepatic membrane-embedded transporter proteins are involved in trafficking endogenous and exogenous substrates. Even though impact of transporters on pharmacokinetics is recognized, little is known on maturation of transporter protein expression levels, especially during early life. We aimed t...

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Veröffentlicht in:	Drug metabolism and disposition 2016-07, Vol.44 (7), p.1005-1013
Hauptverfasser:	Mooij, Miriam G, van de Steeg, Evita, van Rosmalen, Joost, Windster, Jonathan D, de Koning, Barbara A.E, Vaes, Wouter H. J, van Groen, Bianca D, Tibboel, Dick, Wortelboer, Heleen M, de Wildt, Saskia N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aging - metabolism ATP-Binding Cassette Transporters - metabolism Gestational Age Glucose Transporter Type 1 - metabolism Humans Infant Infant, Newborn Liver - metabolism Membrane Transport Proteins - metabolism Monocarboxylic Acid Transporters - metabolism Organic Anion Transporters - metabolism Organic Cation Transport Proteins - metabolism Proteomics - methods Symporters - metabolism
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