Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats

Carbamazepine (CBZ) is widely used as an antiepileptic agent and causes rare but severe liver injury in humans. It has been generally recognized that reactive metabolites formed via the metabolic activation reaction contribute to the onset of liver injuries by several drugs. However, the role of CBZ...

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Veröffentlicht in:	Drug metabolism and disposition 2015-07, Vol.43 (7), p.958-968
Hauptverfasser:	Iida, Azumi, Sasaki, Eita, Yano, Azusa, Tsuneyama, Koichi, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - metabolism Animals Anti-Bacterial Agents - pharmacology Antifungal Agents - pharmacology Buthionine Sulfoximine - pharmacology Carbamazepine - metabolism Carbamazepine - toxicity Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - metabolism Cytochrome P-450 CYP3A - metabolism Enzyme Induction - drug effects Enzyme Inhibitors - pharmacology Glutathione - antagonists & inhibitors Glutathione - metabolism Hydroxylation Ketoconazole - pharmacology Liver - drug effects Liver - enzymology Liver - metabolism Male Microsomes, Liver - drug effects Microsomes, Liver - enzymology Rats Rats, Inbred F344 Troleandomycin - pharmacology
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