Targeted Screen for Human UDP-Glucuronosyltransferases Inhibitors and the Evaluation of Potential Drug-Drug Interactions with Zafirlukast

Inhibition of drug metabolizing enzymes is a major mechanism in drug-drug interactions (DDIs). A number of cases of DDIs via inhibition of UDP-glucuronosyltranseferases (UGTs) have been reported, although the changes in pharmacokinetics are relatively small in comparison with drugs that are metaboli...

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Veröffentlicht in:	Drug metabolism and disposition 2015-06, Vol.43 (6), p.812-818
Hauptverfasser:	Oda, Shingo, Fujiwara, Ryoichi, Kutsuno, Yuki, Fukami, Tatsuki, Itoh, Tomoo, Yokoi, Tsuyoshi, Nakajima, Miki
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Evaluation, Preclinical Drug Interactions Enzyme Inhibitors - adverse effects Enzyme Inhibitors - pharmacology Glucuronosyltransferase - antagonists & inhibitors Glucuronosyltransferase - genetics Glucuronosyltransferase - metabolism Humans Intestinal Mucosa - drug effects Intestinal Mucosa - enzymology Intestine, Small - drug effects Intestine, Small - enzymology Isoenzymes - antagonists & inhibitors Isoenzymes - genetics Isoenzymes - metabolism Kinetics Leukotriene Antagonists - adverse effects Leukotriene Antagonists - metabolism Leukotriene Antagonists - pharmacology Metabolic Detoxication, Phase II Microsomes - drug effects Microsomes - enzymology Microsomes, Liver - drug effects Microsomes, Liver - enzymology Raloxifene Hydrochloride - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Selective Estrogen Receptor Modulators - metabolism Small Molecule Libraries Substrate Specificity Tosyl Compounds - adverse effects Tosyl Compounds - metabolism Tosyl Compounds - pharmacology
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