Metabolic Chiral Inversion of Brivanib and Its Relevance to Safety and Pharmacology

Brivanib alaninate is an orally administered alanine prodrug of brivanib, a dual inhibitor of the vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) signaling pathways. It is currently in clinical trials for the treatment of hepatocellular carcinoma and colorectal cancer. B...

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Veröffentlicht in:	Drug metabolism and disposition 2012-12, Vol.40 (12), p.2374-2380
Hauptverfasser:	Gong, Jiachang, Gan, Jinping, Masson, Eric, Syed, Shariq, Xia, Yuan-Qing, Williams, Daphne, Pursley, Janice, Jemal, Mohammed, Humphreys, W. Griff, Iyer, Ramaswamy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Alanine - adverse effects Alanine - analogs & derivatives Alanine - pharmacokinetics Alanine - pharmacology Animals Area Under Curve Cytosol - metabolism Female Humans Ketones - metabolism Macaca fascicularis Male Microsomes, Liver - metabolism Middle Aged NADP - metabolism Oxidation-Reduction Rats Rats, Sprague-Dawley Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors Triazines - adverse effects Triazines - pharmacokinetics Triazines - pharmacology Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Young Adult
Online-Zugang:	Volltext
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