In Vitro Inhibition and Induction of Human Liver Cytochrome P450 Enzymes by Milnacipran

Milnacipran (Savella) inhibits both norepinephrine and serotonin reuptake and is distinguished by a nearly 3-fold greater potency in inhibiting norepinephrine reuptake in vitro compared with serotonin. We evaluated the ability of milnacipran to inhibit and induce human cytochrome P450 enzymes in vit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Drug metabolism and disposition 2009-10, Vol.37 (10), p.2045-2054
Hauptverfasser:	Paris, Brandy L., Ogilvie, Brian W., Scheinkoenig, Julie A., Ndikum-Moffor, Florence, Gibson, Remi, Parkinson, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Ulcer Agents - pharmacology Antitubercular Agents - pharmacology Biological and medical sciences Cyclopropanes - pharmacology Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP2D6 - metabolism Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism Drug Interactions Enzyme Induction - drug effects Hepatocytes - drug effects Hepatocytes - enzymology Humans Hypoglycemic Agents - pharmacology Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology Midazolam - pharmacology Middle Aged Milnacipran Omeprazole - pharmacology Pharmacology. Drug treatments Serotonin Uptake Inhibitors - pharmacology Testosterone - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!