Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters

The antiparasitic activity of aromatic diamidine drugs, pentamidine and furamidine, depends on their entry into the pathogenic protozoa via membrane transporters. However, no such diamidine transporter has been identified in mammalian cells. The goal of this study is to investigate whether these dic...

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Veröffentlicht in:	Drug metabolism and disposition 2009-02, Vol.37 (2), p.424-430
Hauptverfasser:	Ming, Xin, Ju, Wujian, Wu, Huali, Tidwell, Richard R., Hall, James E., Thakker, Dhiren R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - pharmacology Benzamidines - pharmacology Biological and medical sciences Biological Transport - physiology Cations - metabolism Female Glucuronides - chemistry Humans Medical sciences Organic Cation Transport Proteins - antagonists & inhibitors Organic Cation Transport Proteins - metabolism Organic Cation Transporter 1 - antagonists & inhibitors Organic Cation Transporter 1 - metabolism Pentamidine - pharmacology Pharmacology. Drug treatments
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