The effects of click level, click rate, and level of background masking noise on the inferior colliculus potential (ICP) in the normal and carboplatin-treated chinchilla

Carboplatin produces a selective loss of inner hair cells in chinchilla, substantially reducing the amplitude of the compound action potential. A key question that arises from these experiments is: What effect does a reduction in IHC-eighth-nerve fiber input have on the central auditory nervous syst...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of the Acoustical Society of America 1997-12, Vol.102 (6), p.3620-3627
Hauptverfasser: Burkard, R, Trautwein, P, Salvi, R
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 3627
container_issue 6
container_start_page 3620
container_title The Journal of the Acoustical Society of America
container_volume 102
creator Burkard, R
Trautwein, P
Salvi, R
description Carboplatin produces a selective loss of inner hair cells in chinchilla, substantially reducing the amplitude of the compound action potential. A key question that arises from these experiments is: What effect does a reduction in IHC-eighth-nerve fiber input have on the central auditory nervous system? This investigation evaluated the inferior colliculus potential (ICP) in chinchillas treated with carboplatin. The left ear was surgically destroyed and a recording electrode was placed in the left inferior colliculus. Following thirteen days of recovery time, the ICP was recorded in the awake animal. Click level was varied from 10-20 to 80 dB pSPL. Click rate was varied from 10 to 1000 Hz using both conventional averaging and a cross-correlation procedure. Broadband masking noise was varied from 30 to 70 dB SPL with click level held constant at 80 dB pSPL. The dependent variables were the positive peak latency and peak-to-following trough amplitude of the evoked potential. Following baseline studies, the animals were administered carboplatin (50 mg/kg IP) and retested two weeks later. Prior to carboplatin administration, there was an increase in ICP latency and a decrease in ICP amplitude with decreasing stimulus level, increasing rate and increasing noise level. Mean ICP threshold was 30 dB pSPL. Following carboplatin administration, there was little change in threshold or peak latencies. In contrast, the amplitude of the ICP was reduced on average by one-third, although this effect varied considerably across animals. The magnitude of this amplitude decrement was not strongly dependent on click level, click rate, or the level of background noise.
doi_str_mv 10.1121/1.420149
format Article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1121_1_420149</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>9407655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c278t-2934c4a29c339786a62a78e33a6d0f0771e8c5ba40c85e531070e0c0886edcca3</originalsourceid><addsrcrecordid>eNo9kF1LwzAUhoMoc07BPyDkcsI6k6Yf6aUMPwYDvZjXJU1Pt7g0KUkr-JP8l2Z2eHE4nJeH58CL0C0lS0pj-kCXSUxoUpyhKU1jEvE0Ts7RlBBCo6TIskt05f1nOFPOigmaFAnJszSdop_tHjA0DcjeY9tgqZU8YA1foBenw4keFliYeoyPVCXkYefsELJW-IMyO2ys8oCtwX0QKtOAU9ZhaXVwDHrwuLM9mF4Jjefr1ft9YP5QY10bsqNeClfZTotemah3EN6GbK9MGK3FNbpohPZwc9oz9PH8tF29Rpu3l_XqcRPJOOd9FBcskYmIC8lYkfNMZLHIOTAmspo0JM8pcJlWIiGSp5AySnICRBLOM6ilFGyG5qNXOuu9g6bsnGqF-y4pKY9ll7Qcyw7o3Yh2Q9VC_Q-e2mW_jwp7FQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The effects of click level, click rate, and level of background masking noise on the inferior colliculus potential (ICP) in the normal and carboplatin-treated chinchilla</title><source>MEDLINE</source><source>AIP Acoustical Society of America</source><creator>Burkard, R ; Trautwein, P ; Salvi, R</creator><creatorcontrib>Burkard, R ; Trautwein, P ; Salvi, R</creatorcontrib><description>Carboplatin produces a selective loss of inner hair cells in chinchilla, substantially reducing the amplitude of the compound action potential. A key question that arises from these experiments is: What effect does a reduction in IHC-eighth-nerve fiber input have on the central auditory nervous system? This investigation evaluated the inferior colliculus potential (ICP) in chinchillas treated with carboplatin. The left ear was surgically destroyed and a recording electrode was placed in the left inferior colliculus. Following thirteen days of recovery time, the ICP was recorded in the awake animal. Click level was varied from 10-20 to 80 dB pSPL. Click rate was varied from 10 to 1000 Hz using both conventional averaging and a cross-correlation procedure. Broadband masking noise was varied from 30 to 70 dB SPL with click level held constant at 80 dB pSPL. The dependent variables were the positive peak latency and peak-to-following trough amplitude of the evoked potential. Following baseline studies, the animals were administered carboplatin (50 mg/kg IP) and retested two weeks later. Prior to carboplatin administration, there was an increase in ICP latency and a decrease in ICP amplitude with decreasing stimulus level, increasing rate and increasing noise level. Mean ICP threshold was 30 dB pSPL. Following carboplatin administration, there was little change in threshold or peak latencies. In contrast, the amplitude of the ICP was reduced on average by one-third, although this effect varied considerably across animals. The magnitude of this amplitude decrement was not strongly dependent on click level, click rate, or the level of background noise.</description><identifier>ISSN: 0001-4966</identifier><identifier>EISSN: 1520-8524</identifier><identifier>DOI: 10.1121/1.420149</identifier><identifier>PMID: 9407655</identifier><language>eng</language><publisher>United States</publisher><subject>Acoustic Stimulation ; Animals ; Antineoplastic Agents - pharmacology ; Audiometry, Evoked Response ; Auditory Perception - drug effects ; Carboplatin - pharmacology ; Chinchilla ; Hair Cells, Auditory, Inner - drug effects ; Inferior Colliculi - drug effects ; Noise ; Perceptual Masking</subject><ispartof>The Journal of the Acoustical Society of America, 1997-12, Vol.102 (6), p.3620-3627</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c278t-2934c4a29c339786a62a78e33a6d0f0771e8c5ba40c85e531070e0c0886edcca3</citedby><cites>FETCH-LOGICAL-c278t-2934c4a29c339786a62a78e33a6d0f0771e8c5ba40c85e531070e0c0886edcca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>207,314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9407655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burkard, R</creatorcontrib><creatorcontrib>Trautwein, P</creatorcontrib><creatorcontrib>Salvi, R</creatorcontrib><title>The effects of click level, click rate, and level of background masking noise on the inferior colliculus potential (ICP) in the normal and carboplatin-treated chinchilla</title><title>The Journal of the Acoustical Society of America</title><addtitle>J Acoust Soc Am</addtitle><description>Carboplatin produces a selective loss of inner hair cells in chinchilla, substantially reducing the amplitude of the compound action potential. A key question that arises from these experiments is: What effect does a reduction in IHC-eighth-nerve fiber input have on the central auditory nervous system? This investigation evaluated the inferior colliculus potential (ICP) in chinchillas treated with carboplatin. The left ear was surgically destroyed and a recording electrode was placed in the left inferior colliculus. Following thirteen days of recovery time, the ICP was recorded in the awake animal. Click level was varied from 10-20 to 80 dB pSPL. Click rate was varied from 10 to 1000 Hz using both conventional averaging and a cross-correlation procedure. Broadband masking noise was varied from 30 to 70 dB SPL with click level held constant at 80 dB pSPL. The dependent variables were the positive peak latency and peak-to-following trough amplitude of the evoked potential. Following baseline studies, the animals were administered carboplatin (50 mg/kg IP) and retested two weeks later. Prior to carboplatin administration, there was an increase in ICP latency and a decrease in ICP amplitude with decreasing stimulus level, increasing rate and increasing noise level. Mean ICP threshold was 30 dB pSPL. Following carboplatin administration, there was little change in threshold or peak latencies. In contrast, the amplitude of the ICP was reduced on average by one-third, although this effect varied considerably across animals. The magnitude of this amplitude decrement was not strongly dependent on click level, click rate, or the level of background noise.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Audiometry, Evoked Response</subject><subject>Auditory Perception - drug effects</subject><subject>Carboplatin - pharmacology</subject><subject>Chinchilla</subject><subject>Hair Cells, Auditory, Inner - drug effects</subject><subject>Inferior Colliculi - drug effects</subject><subject>Noise</subject><subject>Perceptual Masking</subject><issn>0001-4966</issn><issn>1520-8524</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUhoMoc07BPyDkcsI6k6Yf6aUMPwYDvZjXJU1Pt7g0KUkr-JP8l2Z2eHE4nJeH58CL0C0lS0pj-kCXSUxoUpyhKU1jEvE0Ts7RlBBCo6TIskt05f1nOFPOigmaFAnJszSdop_tHjA0DcjeY9tgqZU8YA1foBenw4keFliYeoyPVCXkYefsELJW-IMyO2ys8oCtwX0QKtOAU9ZhaXVwDHrwuLM9mF4Jjefr1ft9YP5QY10bsqNeClfZTotemah3EN6GbK9MGK3FNbpohPZwc9oz9PH8tF29Rpu3l_XqcRPJOOd9FBcskYmIC8lYkfNMZLHIOTAmspo0JM8pcJlWIiGSp5AySnICRBLOM6ilFGyG5qNXOuu9g6bsnGqF-y4pKY9ll7Qcyw7o3Yh2Q9VC_Q-e2mW_jwp7FQ</recordid><startdate>199712</startdate><enddate>199712</enddate><creator>Burkard, R</creator><creator>Trautwein, P</creator><creator>Salvi, R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199712</creationdate><title>The effects of click level, click rate, and level of background masking noise on the inferior colliculus potential (ICP) in the normal and carboplatin-treated chinchilla</title><author>Burkard, R ; Trautwein, P ; Salvi, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-2934c4a29c339786a62a78e33a6d0f0771e8c5ba40c85e531070e0c0886edcca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Audiometry, Evoked Response</topic><topic>Auditory Perception - drug effects</topic><topic>Carboplatin - pharmacology</topic><topic>Chinchilla</topic><topic>Hair Cells, Auditory, Inner - drug effects</topic><topic>Inferior Colliculi - drug effects</topic><topic>Noise</topic><topic>Perceptual Masking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burkard, R</creatorcontrib><creatorcontrib>Trautwein, P</creatorcontrib><creatorcontrib>Salvi, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Journal of the Acoustical Society of America</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burkard, R</au><au>Trautwein, P</au><au>Salvi, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of click level, click rate, and level of background masking noise on the inferior colliculus potential (ICP) in the normal and carboplatin-treated chinchilla</atitle><jtitle>The Journal of the Acoustical Society of America</jtitle><addtitle>J Acoust Soc Am</addtitle><date>1997-12</date><risdate>1997</risdate><volume>102</volume><issue>6</issue><spage>3620</spage><epage>3627</epage><pages>3620-3627</pages><issn>0001-4966</issn><eissn>1520-8524</eissn><abstract>Carboplatin produces a selective loss of inner hair cells in chinchilla, substantially reducing the amplitude of the compound action potential. A key question that arises from these experiments is: What effect does a reduction in IHC-eighth-nerve fiber input have on the central auditory nervous system? This investigation evaluated the inferior colliculus potential (ICP) in chinchillas treated with carboplatin. The left ear was surgically destroyed and a recording electrode was placed in the left inferior colliculus. Following thirteen days of recovery time, the ICP was recorded in the awake animal. Click level was varied from 10-20 to 80 dB pSPL. Click rate was varied from 10 to 1000 Hz using both conventional averaging and a cross-correlation procedure. Broadband masking noise was varied from 30 to 70 dB SPL with click level held constant at 80 dB pSPL. The dependent variables were the positive peak latency and peak-to-following trough amplitude of the evoked potential. Following baseline studies, the animals were administered carboplatin (50 mg/kg IP) and retested two weeks later. Prior to carboplatin administration, there was an increase in ICP latency and a decrease in ICP amplitude with decreasing stimulus level, increasing rate and increasing noise level. Mean ICP threshold was 30 dB pSPL. Following carboplatin administration, there was little change in threshold or peak latencies. In contrast, the amplitude of the ICP was reduced on average by one-third, although this effect varied considerably across animals. The magnitude of this amplitude decrement was not strongly dependent on click level, click rate, or the level of background noise.</abstract><cop>United States</cop><pmid>9407655</pmid><doi>10.1121/1.420149</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0001-4966
ispartof The Journal of the Acoustical Society of America, 1997-12, Vol.102 (6), p.3620-3627
issn 0001-4966
1520-8524
language eng
recordid cdi_crossref_primary_10_1121_1_420149
source MEDLINE; AIP Acoustical Society of America
subjects Acoustic Stimulation
Animals
Antineoplastic Agents - pharmacology
Audiometry, Evoked Response
Auditory Perception - drug effects
Carboplatin - pharmacology
Chinchilla
Hair Cells, Auditory, Inner - drug effects
Inferior Colliculi - drug effects
Noise
Perceptual Masking
title The effects of click level, click rate, and level of background masking noise on the inferior colliculus potential (ICP) in the normal and carboplatin-treated chinchilla
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A21%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effects%20of%20click%20level,%20click%20rate,%20and%20level%20of%20background%20masking%20noise%20on%20the%20inferior%20colliculus%20potential%20(ICP)%20in%20the%20normal%20and%20carboplatin-treated%20chinchilla&rft.jtitle=The%20Journal%20of%20the%20Acoustical%20Society%20of%20America&rft.au=Burkard,%20R&rft.date=1997-12&rft.volume=102&rft.issue=6&rft.spage=3620&rft.epage=3627&rft.pages=3620-3627&rft.issn=0001-4966&rft.eissn=1520-8524&rft_id=info:doi/10.1121/1.420149&rft_dat=%3Cpubmed_cross%3E9407655%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/9407655&rfr_iscdi=true