Active Doppler monitoring of de novo cavitation induced by a dual-mode pulsed high-intensity focused ultrasound array

Pulsed high-intensity focused ultrasound (pHIFU) is capable of inducing inertial cavitation in tissues without the need for microbubbles or other ultrasound contrast agents, thereby permeabilizing the tissue to enhance passive diffusion of systemically administered therapeutic agents. Here, we repor...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of the Acoustical Society of America 2023-10, Vol.154 (4_supplement), p.A277-A277
Hauptverfasser: Williams, Randall P., Song, Minho, Wang, Yak-Nam, Totten, Stephanie, Khokhlova, Tatiana
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page A277
container_issue 4_supplement
container_start_page A277
container_title The Journal of the Acoustical Society of America
container_volume 154
creator Williams, Randall P.
Song, Minho
Wang, Yak-Nam
Totten, Stephanie
Khokhlova, Tatiana
description Pulsed high-intensity focused ultrasound (pHIFU) is capable of inducing inertial cavitation in tissues without the need for microbubbles or other ultrasound contrast agents, thereby permeabilizing the tissue to enhance passive diffusion of systemically administered therapeutic agents. Here, we report on the use of ultrafast, synchronous power Doppler imaging to spatially map cavitation activity and resulting tissue disruption in ex vivo and invivo porcine tissues using a dual-mode imaging-therapy linear pHIFU array. The array (64 elements, aperture 51.2 mm × 14 mm, frequency 1.0MHz, 40% bandwidth) was driven by a power-enhanced Verasonics V1 system to deliver a series of 1 ms pulses at a 1% duty cycle while electronically scanning the pHIFU focus over an azimuthal range of ±1 cm. Plane wave Doppler ensembles were captured immediately after each pHIFU pulse to map the distribution and characteristics of the remnants of cavitation bubbles. The degree of resulting tissue disruption was assessed by histology and was correlated with cumulative Doppler power contours computed over the exposure region. The results show that ultrafast synchronous power Doppler is a promising approach for real-time quantitative monitoring of cavitational therapies. [Work supported by NIH R01EB023910 and T32DK007742.]
doi_str_mv 10.1121/10.0023516
format Article
fullrecord <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_1121_10_0023516</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1121_10_0023516</sourcerecordid><originalsourceid>FETCH-crossref_primary_10_1121_10_00235163</originalsourceid><addsrcrecordid>eNqVj0tqxDAQREVIIM5nkxP0OqBEssdmZhnyIQeYvelI8kwHW230Mfj2kWEukNWjileLEuJJqxeta_1aqFTdtLq7EpVuayX3bb27FpVSSsvdoetuxV2MvyW2--ZQifxmEi0OPnieRxdgYk-JA_kT8ADWgeeFweBCCROxB_I2G2fhZwUEm3GUExdtzmMs7ZlOZ0k-OR8prTCwyVudxxQwcvYWMARcH8TNgGXweOG9eP76PL5_SxM4xuCGfg40YVh7rfrt2MbLseZf8h_5hFUd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Active Doppler monitoring of de novo cavitation induced by a dual-mode pulsed high-intensity focused ultrasound array</title><source>AIP Journals Complete</source><source>Alma/SFX Local Collection</source><source>AIP Acoustical Society of America</source><creator>Williams, Randall P. ; Song, Minho ; Wang, Yak-Nam ; Totten, Stephanie ; Khokhlova, Tatiana</creator><creatorcontrib>Williams, Randall P. ; Song, Minho ; Wang, Yak-Nam ; Totten, Stephanie ; Khokhlova, Tatiana</creatorcontrib><description>Pulsed high-intensity focused ultrasound (pHIFU) is capable of inducing inertial cavitation in tissues without the need for microbubbles or other ultrasound contrast agents, thereby permeabilizing the tissue to enhance passive diffusion of systemically administered therapeutic agents. Here, we report on the use of ultrafast, synchronous power Doppler imaging to spatially map cavitation activity and resulting tissue disruption in ex vivo and invivo porcine tissues using a dual-mode imaging-therapy linear pHIFU array. The array (64 elements, aperture 51.2 mm × 14 mm, frequency 1.0MHz, 40% bandwidth) was driven by a power-enhanced Verasonics V1 system to deliver a series of 1 ms pulses at a 1% duty cycle while electronically scanning the pHIFU focus over an azimuthal range of ±1 cm. Plane wave Doppler ensembles were captured immediately after each pHIFU pulse to map the distribution and characteristics of the remnants of cavitation bubbles. The degree of resulting tissue disruption was assessed by histology and was correlated with cumulative Doppler power contours computed over the exposure region. The results show that ultrafast synchronous power Doppler is a promising approach for real-time quantitative monitoring of cavitational therapies. [Work supported by NIH R01EB023910 and T32DK007742.]</description><identifier>ISSN: 0001-4966</identifier><identifier>EISSN: 1520-8524</identifier><identifier>DOI: 10.1121/10.0023516</identifier><language>eng</language><ispartof>The Journal of the Acoustical Society of America, 2023-10, Vol.154 (4_supplement), p.A277-A277</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>207,208,314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Williams, Randall P.</creatorcontrib><creatorcontrib>Song, Minho</creatorcontrib><creatorcontrib>Wang, Yak-Nam</creatorcontrib><creatorcontrib>Totten, Stephanie</creatorcontrib><creatorcontrib>Khokhlova, Tatiana</creatorcontrib><title>Active Doppler monitoring of de novo cavitation induced by a dual-mode pulsed high-intensity focused ultrasound array</title><title>The Journal of the Acoustical Society of America</title><description>Pulsed high-intensity focused ultrasound (pHIFU) is capable of inducing inertial cavitation in tissues without the need for microbubbles or other ultrasound contrast agents, thereby permeabilizing the tissue to enhance passive diffusion of systemically administered therapeutic agents. Here, we report on the use of ultrafast, synchronous power Doppler imaging to spatially map cavitation activity and resulting tissue disruption in ex vivo and invivo porcine tissues using a dual-mode imaging-therapy linear pHIFU array. The array (64 elements, aperture 51.2 mm × 14 mm, frequency 1.0MHz, 40% bandwidth) was driven by a power-enhanced Verasonics V1 system to deliver a series of 1 ms pulses at a 1% duty cycle while electronically scanning the pHIFU focus over an azimuthal range of ±1 cm. Plane wave Doppler ensembles were captured immediately after each pHIFU pulse to map the distribution and characteristics of the remnants of cavitation bubbles. The degree of resulting tissue disruption was assessed by histology and was correlated with cumulative Doppler power contours computed over the exposure region. The results show that ultrafast synchronous power Doppler is a promising approach for real-time quantitative monitoring of cavitational therapies. [Work supported by NIH R01EB023910 and T32DK007742.]</description><issn>0001-4966</issn><issn>1520-8524</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqVj0tqxDAQREVIIM5nkxP0OqBEssdmZhnyIQeYvelI8kwHW230Mfj2kWEukNWjileLEuJJqxeta_1aqFTdtLq7EpVuayX3bb27FpVSSsvdoetuxV2MvyW2--ZQifxmEi0OPnieRxdgYk-JA_kT8ADWgeeFweBCCROxB_I2G2fhZwUEm3GUExdtzmMs7ZlOZ0k-OR8prTCwyVudxxQwcvYWMARcH8TNgGXweOG9eP76PL5_SxM4xuCGfg40YVh7rfrt2MbLseZf8h_5hFUd</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Williams, Randall P.</creator><creator>Song, Minho</creator><creator>Wang, Yak-Nam</creator><creator>Totten, Stephanie</creator><creator>Khokhlova, Tatiana</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20231001</creationdate><title>Active Doppler monitoring of de novo cavitation induced by a dual-mode pulsed high-intensity focused ultrasound array</title><author>Williams, Randall P. ; Song, Minho ; Wang, Yak-Nam ; Totten, Stephanie ; Khokhlova, Tatiana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-crossref_primary_10_1121_10_00235163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Randall P.</creatorcontrib><creatorcontrib>Song, Minho</creatorcontrib><creatorcontrib>Wang, Yak-Nam</creatorcontrib><creatorcontrib>Totten, Stephanie</creatorcontrib><creatorcontrib>Khokhlova, Tatiana</creatorcontrib><collection>CrossRef</collection><jtitle>The Journal of the Acoustical Society of America</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Randall P.</au><au>Song, Minho</au><au>Wang, Yak-Nam</au><au>Totten, Stephanie</au><au>Khokhlova, Tatiana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Active Doppler monitoring of de novo cavitation induced by a dual-mode pulsed high-intensity focused ultrasound array</atitle><jtitle>The Journal of the Acoustical Society of America</jtitle><date>2023-10-01</date><risdate>2023</risdate><volume>154</volume><issue>4_supplement</issue><spage>A277</spage><epage>A277</epage><pages>A277-A277</pages><issn>0001-4966</issn><eissn>1520-8524</eissn><abstract>Pulsed high-intensity focused ultrasound (pHIFU) is capable of inducing inertial cavitation in tissues without the need for microbubbles or other ultrasound contrast agents, thereby permeabilizing the tissue to enhance passive diffusion of systemically administered therapeutic agents. Here, we report on the use of ultrafast, synchronous power Doppler imaging to spatially map cavitation activity and resulting tissue disruption in ex vivo and invivo porcine tissues using a dual-mode imaging-therapy linear pHIFU array. The array (64 elements, aperture 51.2 mm × 14 mm, frequency 1.0MHz, 40% bandwidth) was driven by a power-enhanced Verasonics V1 system to deliver a series of 1 ms pulses at a 1% duty cycle while electronically scanning the pHIFU focus over an azimuthal range of ±1 cm. Plane wave Doppler ensembles were captured immediately after each pHIFU pulse to map the distribution and characteristics of the remnants of cavitation bubbles. The degree of resulting tissue disruption was assessed by histology and was correlated with cumulative Doppler power contours computed over the exposure region. The results show that ultrafast synchronous power Doppler is a promising approach for real-time quantitative monitoring of cavitational therapies. [Work supported by NIH R01EB023910 and T32DK007742.]</abstract><doi>10.1121/10.0023516</doi></addata></record>
fulltext fulltext
identifier ISSN: 0001-4966
ispartof The Journal of the Acoustical Society of America, 2023-10, Vol.154 (4_supplement), p.A277-A277
issn 0001-4966
1520-8524
language eng
recordid cdi_crossref_primary_10_1121_10_0023516
source AIP Journals Complete; Alma/SFX Local Collection; AIP Acoustical Society of America
title Active Doppler monitoring of de novo cavitation induced by a dual-mode pulsed high-intensity focused ultrasound array
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T11%3A37%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Active%20Doppler%20monitoring%20of%20de%20novo%20cavitation%20induced%20by%20a%20dual-mode%20pulsed%20high-intensity%20focused%20ultrasound%20array&rft.jtitle=The%20Journal%20of%20the%20Acoustical%20Society%20of%20America&rft.au=Williams,%20Randall%20P.&rft.date=2023-10-01&rft.volume=154&rft.issue=4_supplement&rft.spage=A277&rft.epage=A277&rft.pages=A277-A277&rft.issn=0001-4966&rft.eissn=1520-8524&rft_id=info:doi/10.1121/10.0023516&rft_dat=%3Ccrossref%3E10_1121_10_0023516%3C/crossref%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true