Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions
Purpose: To assess the hypothesis that the volume of whole brain that receives a certain dose level is primarily dependent on the treated volume rather than on the number, shape, or location of the lesions. This would help a physician validate the suitability of GammaKnife® based stereotactic radios...
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| Veröffentlicht in: | Medical physics (Lancaster) 2013-09, Vol.40 (9), p.091714-n/a |
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| creator | Narayanasamy, Ganesh Smith, Adam Van Meter, Emily McGarry, Ronald Molloy, Janelle A. |
| description | Purpose:
To assess the hypothesis that the volume of whole brain that receives a certain dose level is primarily dependent on the treated volume rather than on the number, shape, or location of the lesions. This would help a physician validate the suitability of GammaKnife® based stereotactic radiosurgery (GKSR) prior to treatment.
Methods:
Simulation studies were performed to establish the hypothesis for both oblong and spherical shaped lesions of various numbers and sizes. Forty patients who underwent GKSR [mean age of 54 years (range 7–80), mean number of lesions of 2.5 (range 1–6), and mean lesion volume of 4.4 cm3 (range 0.02–22.2 cm3)] were also studied retrospectively. Following recommendations of QUANTEC, the volume of brain irradiated by the 12 Gy (VB12) isodose line was measured and a power-law based relation is proposed here for estimating VB12 from the known tumor volume and the prescription dose.
Results:
In the simulation study on oblong, spherical, and multiple lesions, the volume of brain irradiated by 50%, 10%, and 1% of maximum dose was found to have linear, linear, and exponentially increasing dependence on the volume of the treated region, respectively. In the retrospective study on 40 GKSR patients, a similar relationship was found to predict the brain dose with a Spearman correlation coefficient >0.9. In both the studies, the volume of brain irradiated by a certain dose level does not have a statistically significant relationship (p ≥ 0.05) with the number, shape, or position of the lesions. The measured VB12 agrees with calculation to within 1.7%.
Conclusions:
The results from the simulation and the retrospective clinical studies indicate that the volume of whole brain that receives a certain percentage of the maximum dose is primarily dependent on the treated volume and less on the number, shape, and location of the lesions. |
| doi_str_mv | 10.1118/1.4818825 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1118_1_4818825</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1430855115</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4835-e3f2afeda5f80ad5bc6db9cc7a1b82364150475c98afd8656b7207f87be6568f3</originalsourceid><addsrcrecordid>eNp9kc9u1DAQhy0EotvCgRdAPkLVFDuxE-8FCVX8k4rgUM7WxBnvGjnxYjtb7YPwvnjZpSqHcrE1nk_fWPMj5AVnl5xz9YZfCsWVquUjsqhF11SiZsvHZMHYUlS1YPKEnKb0gzHWNpI9JSfljXVcdAvy6yZk8DRDXGGm2-DnEalLFGiPOWOkm4iDMzlEGiy9XQePtI_gJjqEhNTGMNIVjCPQVGgsMpOdoREGF9JcpHFH8xqmciCd5rHHeEHTGjZ4QYvTBwPZhWkv3xMeU6nSM_LEgk_4_Hifke8f3t9cfaquv378fPXuujJCNbLCxtZgcQBpFYNB9qYd-qUxHfBe1U0ruGSik2apwA6qlW3f1ayzquuxFMo2Z-TtwbuZ-xEHg1OO4PUmuhHiTgdw-t_O5NZ6FbZacKa6ui6CV0dBDD9nTFmPLhn0HiYMc9JcNExJybks6OsDamJIKaK9G8OZ3seouT7GWNiX9_91R_7NrQDVAbh1HncPm_SXb0fh-YFPxuU_G__v9AfhbYj35JvBNr8BoZfFag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1430855115</pqid></control><display><type>article</type><title>Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Narayanasamy, Ganesh ; Smith, Adam ; Van Meter, Emily ; McGarry, Ronald ; Molloy, Janelle A.</creator><creatorcontrib>Narayanasamy, Ganesh ; Smith, Adam ; Van Meter, Emily ; McGarry, Ronald ; Molloy, Janelle A.</creatorcontrib><description>Purpose:
To assess the hypothesis that the volume of whole brain that receives a certain dose level is primarily dependent on the treated volume rather than on the number, shape, or location of the lesions. This would help a physician validate the suitability of GammaKnife® based stereotactic radiosurgery (GKSR) prior to treatment.
Methods:
Simulation studies were performed to establish the hypothesis for both oblong and spherical shaped lesions of various numbers and sizes. Forty patients who underwent GKSR [mean age of 54 years (range 7–80), mean number of lesions of 2.5 (range 1–6), and mean lesion volume of 4.4 cm3 (range 0.02–22.2 cm3)] were also studied retrospectively. Following recommendations of QUANTEC, the volume of brain irradiated by the 12 Gy (VB12) isodose line was measured and a power-law based relation is proposed here for estimating VB12 from the known tumor volume and the prescription dose.
Results:
In the simulation study on oblong, spherical, and multiple lesions, the volume of brain irradiated by 50%, 10%, and 1% of maximum dose was found to have linear, linear, and exponentially increasing dependence on the volume of the treated region, respectively. In the retrospective study on 40 GKSR patients, a similar relationship was found to predict the brain dose with a Spearman correlation coefficient >0.9. In both the studies, the volume of brain irradiated by a certain dose level does not have a statistically significant relationship (p ≥ 0.05) with the number, shape, or position of the lesions. The measured VB12 agrees with calculation to within 1.7%.
Conclusions:
The results from the simulation and the retrospective clinical studies indicate that the volume of whole brain that receives a certain percentage of the maximum dose is primarily dependent on the treated volume and less on the number, shape, and location of the lesions.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.4818825</identifier><identifier>PMID: 24007147</identifier><identifier>CODEN: MPHYA6</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>Applied neuroscience ; brain ; Brain - pathology ; Brain - radiation effects ; brain dose ; Brain Neoplasms - pathology ; Brain Neoplasms - radiotherapy ; Cancer ; Computer software ; Data analysis ; Dose‐volume analysis ; dosimetry ; gamma knife ; Gamma Rays - therapeutic use ; Humans ; lesion volume ; Magnetic resonance imaging ; Radiation Dosage ; radiation therapy ; Radiation Therapy Physics ; Radiation treatment ; Radiosurgery ; Radiosurgery - methods ; Scintigraphy ; Spatial dimensions ; stereotactic radiosurgery ; surgery ; Surgical instruments, devices or methods, e.g. tourniquets ; Tumor Burden ; tumours</subject><ispartof>Medical physics (Lancaster), 2013-09, Vol.40 (9), p.091714-n/a</ispartof><rights>American Association of Physicists in Medicine</rights><rights>2013 American Association of Physicists in Medicine</rights><rights>Copyright © 2013 American Association of Physicists in Medicine 2013 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4835-e3f2afeda5f80ad5bc6db9cc7a1b82364150475c98afd8656b7207f87be6568f3</citedby><cites>FETCH-LOGICAL-c4835-e3f2afeda5f80ad5bc6db9cc7a1b82364150475c98afd8656b7207f87be6568f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1118%2F1.4818825$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.4818825$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24007147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Narayanasamy, Ganesh</creatorcontrib><creatorcontrib>Smith, Adam</creatorcontrib><creatorcontrib>Van Meter, Emily</creatorcontrib><creatorcontrib>McGarry, Ronald</creatorcontrib><creatorcontrib>Molloy, Janelle A.</creatorcontrib><title>Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Purpose:
To assess the hypothesis that the volume of whole brain that receives a certain dose level is primarily dependent on the treated volume rather than on the number, shape, or location of the lesions. This would help a physician validate the suitability of GammaKnife® based stereotactic radiosurgery (GKSR) prior to treatment.
Methods:
Simulation studies were performed to establish the hypothesis for both oblong and spherical shaped lesions of various numbers and sizes. Forty patients who underwent GKSR [mean age of 54 years (range 7–80), mean number of lesions of 2.5 (range 1–6), and mean lesion volume of 4.4 cm3 (range 0.02–22.2 cm3)] were also studied retrospectively. Following recommendations of QUANTEC, the volume of brain irradiated by the 12 Gy (VB12) isodose line was measured and a power-law based relation is proposed here for estimating VB12 from the known tumor volume and the prescription dose.
Results:
In the simulation study on oblong, spherical, and multiple lesions, the volume of brain irradiated by 50%, 10%, and 1% of maximum dose was found to have linear, linear, and exponentially increasing dependence on the volume of the treated region, respectively. In the retrospective study on 40 GKSR patients, a similar relationship was found to predict the brain dose with a Spearman correlation coefficient >0.9. In both the studies, the volume of brain irradiated by a certain dose level does not have a statistically significant relationship (p ≥ 0.05) with the number, shape, or position of the lesions. The measured VB12 agrees with calculation to within 1.7%.
Conclusions:
The results from the simulation and the retrospective clinical studies indicate that the volume of whole brain that receives a certain percentage of the maximum dose is primarily dependent on the treated volume and less on the number, shape, and location of the lesions.</description><subject>Applied neuroscience</subject><subject>brain</subject><subject>Brain - pathology</subject><subject>Brain - radiation effects</subject><subject>brain dose</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Cancer</subject><subject>Computer software</subject><subject>Data analysis</subject><subject>Dose‐volume analysis</subject><subject>dosimetry</subject><subject>gamma knife</subject><subject>Gamma Rays - therapeutic use</subject><subject>Humans</subject><subject>lesion volume</subject><subject>Magnetic resonance imaging</subject><subject>Radiation Dosage</subject><subject>radiation therapy</subject><subject>Radiation Therapy Physics</subject><subject>Radiation treatment</subject><subject>Radiosurgery</subject><subject>Radiosurgery - methods</subject><subject>Scintigraphy</subject><subject>Spatial dimensions</subject><subject>stereotactic radiosurgery</subject><subject>surgery</subject><subject>Surgical instruments, devices or methods, e.g. tourniquets</subject><subject>Tumor Burden</subject><subject>tumours</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQhy0EotvCgRdAPkLVFDuxE-8FCVX8k4rgUM7WxBnvGjnxYjtb7YPwvnjZpSqHcrE1nk_fWPMj5AVnl5xz9YZfCsWVquUjsqhF11SiZsvHZMHYUlS1YPKEnKb0gzHWNpI9JSfljXVcdAvy6yZk8DRDXGGm2-DnEalLFGiPOWOkm4iDMzlEGiy9XQePtI_gJjqEhNTGMNIVjCPQVGgsMpOdoREGF9JcpHFH8xqmciCd5rHHeEHTGjZ4QYvTBwPZhWkv3xMeU6nSM_LEgk_4_Hifke8f3t9cfaquv378fPXuujJCNbLCxtZgcQBpFYNB9qYd-qUxHfBe1U0ruGSik2apwA6qlW3f1ayzquuxFMo2Z-TtwbuZ-xEHg1OO4PUmuhHiTgdw-t_O5NZ6FbZacKa6ui6CV0dBDD9nTFmPLhn0HiYMc9JcNExJybks6OsDamJIKaK9G8OZ3seouT7GWNiX9_91R_7NrQDVAbh1HncPm_SXb0fh-YFPxuU_G__v9AfhbYj35JvBNr8BoZfFag</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Narayanasamy, Ganesh</creator><creator>Smith, Adam</creator><creator>Van Meter, Emily</creator><creator>McGarry, Ronald</creator><creator>Molloy, Janelle A.</creator><general>American Association of Physicists in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201309</creationdate><title>Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions</title><author>Narayanasamy, Ganesh ; Smith, Adam ; Van Meter, Emily ; McGarry, Ronald ; Molloy, Janelle A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4835-e3f2afeda5f80ad5bc6db9cc7a1b82364150475c98afd8656b7207f87be6568f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Applied neuroscience</topic><topic>brain</topic><topic>Brain - pathology</topic><topic>Brain - radiation effects</topic><topic>brain dose</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Cancer</topic><topic>Computer software</topic><topic>Data analysis</topic><topic>Dose‐volume analysis</topic><topic>dosimetry</topic><topic>gamma knife</topic><topic>Gamma Rays - therapeutic use</topic><topic>Humans</topic><topic>lesion volume</topic><topic>Magnetic resonance imaging</topic><topic>Radiation Dosage</topic><topic>radiation therapy</topic><topic>Radiation Therapy Physics</topic><topic>Radiation treatment</topic><topic>Radiosurgery</topic><topic>Radiosurgery - methods</topic><topic>Scintigraphy</topic><topic>Spatial dimensions</topic><topic>stereotactic radiosurgery</topic><topic>surgery</topic><topic>Surgical instruments, devices or methods, e.g. tourniquets</topic><topic>Tumor Burden</topic><topic>tumours</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Narayanasamy, Ganesh</creatorcontrib><creatorcontrib>Smith, Adam</creatorcontrib><creatorcontrib>Van Meter, Emily</creatorcontrib><creatorcontrib>McGarry, Ronald</creatorcontrib><creatorcontrib>Molloy, Janelle A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Narayanasamy, Ganesh</au><au>Smith, Adam</au><au>Van Meter, Emily</au><au>McGarry, Ronald</au><au>Molloy, Janelle A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2013-09</date><risdate>2013</risdate><volume>40</volume><issue>9</issue><spage>091714</spage><epage>n/a</epage><pages>091714-n/a</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><coden>MPHYA6</coden><abstract>Purpose:
To assess the hypothesis that the volume of whole brain that receives a certain dose level is primarily dependent on the treated volume rather than on the number, shape, or location of the lesions. This would help a physician validate the suitability of GammaKnife® based stereotactic radiosurgery (GKSR) prior to treatment.
Methods:
Simulation studies were performed to establish the hypothesis for both oblong and spherical shaped lesions of various numbers and sizes. Forty patients who underwent GKSR [mean age of 54 years (range 7–80), mean number of lesions of 2.5 (range 1–6), and mean lesion volume of 4.4 cm3 (range 0.02–22.2 cm3)] were also studied retrospectively. Following recommendations of QUANTEC, the volume of brain irradiated by the 12 Gy (VB12) isodose line was measured and a power-law based relation is proposed here for estimating VB12 from the known tumor volume and the prescription dose.
Results:
In the simulation study on oblong, spherical, and multiple lesions, the volume of brain irradiated by 50%, 10%, and 1% of maximum dose was found to have linear, linear, and exponentially increasing dependence on the volume of the treated region, respectively. In the retrospective study on 40 GKSR patients, a similar relationship was found to predict the brain dose with a Spearman correlation coefficient >0.9. In both the studies, the volume of brain irradiated by a certain dose level does not have a statistically significant relationship (p ≥ 0.05) with the number, shape, or position of the lesions. The measured VB12 agrees with calculation to within 1.7%.
Conclusions:
The results from the simulation and the retrospective clinical studies indicate that the volume of whole brain that receives a certain percentage of the maximum dose is primarily dependent on the treated volume and less on the number, shape, and location of the lesions.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>24007147</pmid><doi>10.1118/1.4818825</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Applied neuroscience brain Brain - pathology Brain - radiation effects brain dose Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Cancer Computer software Data analysis Dose‐volume analysis dosimetry gamma knife Gamma Rays - therapeutic use Humans lesion volume Magnetic resonance imaging Radiation Dosage radiation therapy Radiation Therapy Physics Radiation treatment Radiosurgery Radiosurgery - methods Scintigraphy Spatial dimensions stereotactic radiosurgery surgery Surgical instruments, devices or methods, e.g. tourniquets Tumor Burden tumours |
| title | Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions |
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