Estimating the viscoelastic modulus of a thrombus using an ultrasonic shear-wave approach
Purpose: Measurements of the viscoelastic properties of a thrombus can be used to assess whether blood clots are likely to become occlusive or to break apart and leak into the blood circulation and block smaller vessels. An accurate method for estimating both the shear elasticity and viscosity of a...
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| Veröffentlicht in: | Medical physics (Lancaster) 2013-04, Vol.40 (4), p.042901-n/a |
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| creator | Huang, Chih-Chung Chen, Pay-Yu Shih, Cho-Chiang |
| description | Purpose:
Measurements of the viscoelastic properties of a thrombus can be used to assess whether blood clots are likely to become occlusive or to break apart and leak into the blood circulation and block smaller vessels. An accurate method for estimating both the shear elasticity and viscosity of a blood clotin vivo is still lacking, which prompted us to use a novel shear-wave approach to measure the viscoelastic modulus of blood clots.
Methods:
The shear-wave dispersion ultrasound vibrometry was used to measure both the elasticity and viscosity of blood clots. The experimental system was verified by measuring the viscoelastic modulus of phantoms containing gelatin at different concentrations. Blood-clot experiments were carried out using porcine whole blood with hematocrits ranging from 3% to 40%. The measured values for both clots and gelatin phantoms were compared to those obtained using an embedded-sphere method in order to validate the accuracy of the viscoelastic modulus estimations.
Results:
The shear elastic modulus increased from 406.9 ± 15.8 (mean ± SD) Pa for 3% gelatin to 1587.2 ± 28.9 Pa for 7% gelatin, while the viscosity increased from 0.12 ± 0.02 Pa s to 0.86 ± 0.05 Pa s, respectively. The shear modulus increased from 196.8 ± 58.4 Pa for 40%-hematocrit clots to 641.4 ± 76.3 Pa for 3%-hematocrit clots, while the viscosity increased from 0.29 ± 0.02 Pa s to 0.42 ± 0.01 Pa s, respectively.
Conclusions:
The results from the statistical analysis indicated that both the embedded-sphere and shear-wave approaches can provide accurate estimations of the shear elasticity for clots and gelatin phantoms. In contrast, the shear-wave approach as well as other methods of rheological measurements does not provide accurate viscosity estimations for blood clots. However, the measured viscosity range of 0.29–0.42 Pa s is reasonable for blood clots. |
| doi_str_mv | 10.1118/1.4794493 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1118_1_4794493</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1324392262</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4593-3a50b1cb204aa726cf644a9d30d13faeb80f304c86a1c5f03a3ef4a61ab6ef143</originalsourceid><addsrcrecordid>eNp90E1LwzAcBvAgipvTg19AelShmrdm61HGfIGJHvTgKfybJq7SNjNpN_btzWgdgugpJPnlSfIgdErwFSFkck2u-DjlPGV7aEj5mMWc4nQfDTFOeUw5TgboyPsPjLFgCT5EA8qSRKSUDdHbzDdFBU1Rv0fNQkerwiurSwirKqps3patj6yJIOw6W2Vh1vothjpqy8aBt3WQfqHBxWtY6QiWS2dBLY7RgYHS65N-HKHX29nL9D6eP909TG_mseJJymIGCc6IyijmAGMqlBGcQ5oznBNmQGcTbBjmaiKAqMRgBkwbDoJAJrQhnI3QeZcbrv1stW9kFf6gyxJqbVsvCaOcpZQKGuhFR5Wz3jtt5NKFz7uNJFhum5RE9k0Ge9bHtlml8538ri6AuAProtSbv5Pk43MfeNl5r4omFG7r3ZmVdT_8Mjf_4d9P_QJYcpiX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1324392262</pqid></control><display><type>article</type><title>Estimating the viscoelastic modulus of a thrombus using an ultrasonic shear-wave approach</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Huang, Chih-Chung ; Chen, Pay-Yu ; Shih, Cho-Chiang</creator><creatorcontrib>Huang, Chih-Chung ; Chen, Pay-Yu ; Shih, Cho-Chiang</creatorcontrib><description>Purpose:
Measurements of the viscoelastic properties of a thrombus can be used to assess whether blood clots are likely to become occlusive or to break apart and leak into the blood circulation and block smaller vessels. An accurate method for estimating both the shear elasticity and viscosity of a blood clotin vivo is still lacking, which prompted us to use a novel shear-wave approach to measure the viscoelastic modulus of blood clots.
Methods:
The shear-wave dispersion ultrasound vibrometry was used to measure both the elasticity and viscosity of blood clots. The experimental system was verified by measuring the viscoelastic modulus of phantoms containing gelatin at different concentrations. Blood-clot experiments were carried out using porcine whole blood with hematocrits ranging from 3% to 40%. The measured values for both clots and gelatin phantoms were compared to those obtained using an embedded-sphere method in order to validate the accuracy of the viscoelastic modulus estimations.
Results:
The shear elastic modulus increased from 406.9 ± 15.8 (mean ± SD) Pa for 3% gelatin to 1587.2 ± 28.9 Pa for 7% gelatin, while the viscosity increased from 0.12 ± 0.02 Pa s to 0.86 ± 0.05 Pa s, respectively. The shear modulus increased from 196.8 ± 58.4 Pa for 40%-hematocrit clots to 641.4 ± 76.3 Pa for 3%-hematocrit clots, while the viscosity increased from 0.29 ± 0.02 Pa s to 0.42 ± 0.01 Pa s, respectively.
Conclusions:
The results from the statistical analysis indicated that both the embedded-sphere and shear-wave approaches can provide accurate estimations of the shear elasticity for clots and gelatin phantoms. In contrast, the shear-wave approach as well as other methods of rheological measurements does not provide accurate viscosity estimations for blood clots. However, the measured viscosity range of 0.29–0.42 Pa s is reasonable for blood clots.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.4794493</identifier><identifier>PMID: 23556923</identifier><identifier>CODEN: MPHYA6</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>Algorithms ; Animals ; Biological effects of acoustic and ultrasonic energy ; biomechanics ; biomedical measurement ; biomedical ultrasonics ; blood ; Blood Coagulation ; blood vessels ; Blood Viscosity ; Diagnosis using ultrasonic, sonic or infrasonic waves ; Diseases ; Elastic moduli ; Elastic Modulus ; elastic waves ; elasticity ; Elasticity Imaging Techniques - methods ; Fluid mechanics and rheology ; gelatin ; haemorheology ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Measuring for diagnostic purposes; Identification of persons ; Mechanical and electrical properties of tissues and organs ; medical disorders ; phantoms ; Probability theory, stochastic processes, and statistics ; Reproducibility of Results ; Rheometry ; Sensitivity and Specificity ; shear modulus ; Shear rate dependent viscosity ; Shear Strength ; shear wave ; statistical analysis ; Swine ; Thrombosis - blood ; Thrombosis - diagnostic imaging ; Thrombosis - physiopathology ; thrombus ; Transducers ; Ultrasonic transducers ; Ultrasonography ; ultrasound ; Viscoelasticity ; Viscosity ; Viscosity measurements</subject><ispartof>Medical physics (Lancaster), 2013-04, Vol.40 (4), p.042901-n/a</ispartof><rights>American Association of Physicists in Medicine</rights><rights>2013 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4593-3a50b1cb204aa726cf644a9d30d13faeb80f304c86a1c5f03a3ef4a61ab6ef143</citedby><cites>FETCH-LOGICAL-c4593-3a50b1cb204aa726cf644a9d30d13faeb80f304c86a1c5f03a3ef4a61ab6ef143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1118%2F1.4794493$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.4794493$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23556923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Chih-Chung</creatorcontrib><creatorcontrib>Chen, Pay-Yu</creatorcontrib><creatorcontrib>Shih, Cho-Chiang</creatorcontrib><title>Estimating the viscoelastic modulus of a thrombus using an ultrasonic shear-wave approach</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Purpose:
Measurements of the viscoelastic properties of a thrombus can be used to assess whether blood clots are likely to become occlusive or to break apart and leak into the blood circulation and block smaller vessels. An accurate method for estimating both the shear elasticity and viscosity of a blood clotin vivo is still lacking, which prompted us to use a novel shear-wave approach to measure the viscoelastic modulus of blood clots.
Methods:
The shear-wave dispersion ultrasound vibrometry was used to measure both the elasticity and viscosity of blood clots. The experimental system was verified by measuring the viscoelastic modulus of phantoms containing gelatin at different concentrations. Blood-clot experiments were carried out using porcine whole blood with hematocrits ranging from 3% to 40%. The measured values for both clots and gelatin phantoms were compared to those obtained using an embedded-sphere method in order to validate the accuracy of the viscoelastic modulus estimations.
Results:
The shear elastic modulus increased from 406.9 ± 15.8 (mean ± SD) Pa for 3% gelatin to 1587.2 ± 28.9 Pa for 7% gelatin, while the viscosity increased from 0.12 ± 0.02 Pa s to 0.86 ± 0.05 Pa s, respectively. The shear modulus increased from 196.8 ± 58.4 Pa for 40%-hematocrit clots to 641.4 ± 76.3 Pa for 3%-hematocrit clots, while the viscosity increased from 0.29 ± 0.02 Pa s to 0.42 ± 0.01 Pa s, respectively.
Conclusions:
The results from the statistical analysis indicated that both the embedded-sphere and shear-wave approaches can provide accurate estimations of the shear elasticity for clots and gelatin phantoms. In contrast, the shear-wave approach as well as other methods of rheological measurements does not provide accurate viscosity estimations for blood clots. However, the measured viscosity range of 0.29–0.42 Pa s is reasonable for blood clots.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Biological effects of acoustic and ultrasonic energy</subject><subject>biomechanics</subject><subject>biomedical measurement</subject><subject>biomedical ultrasonics</subject><subject>blood</subject><subject>Blood Coagulation</subject><subject>blood vessels</subject><subject>Blood Viscosity</subject><subject>Diagnosis using ultrasonic, sonic or infrasonic waves</subject><subject>Diseases</subject><subject>Elastic moduli</subject><subject>Elastic Modulus</subject><subject>elastic waves</subject><subject>elasticity</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Fluid mechanics and rheology</subject><subject>gelatin</subject><subject>haemorheology</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Measuring for diagnostic purposes; Identification of persons</subject><subject>Mechanical and electrical properties of tissues and organs</subject><subject>medical disorders</subject><subject>phantoms</subject><subject>Probability theory, stochastic processes, and statistics</subject><subject>Reproducibility of Results</subject><subject>Rheometry</subject><subject>Sensitivity and Specificity</subject><subject>shear modulus</subject><subject>Shear rate dependent viscosity</subject><subject>Shear Strength</subject><subject>shear wave</subject><subject>statistical analysis</subject><subject>Swine</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - diagnostic imaging</subject><subject>Thrombosis - physiopathology</subject><subject>thrombus</subject><subject>Transducers</subject><subject>Ultrasonic transducers</subject><subject>Ultrasonography</subject><subject>ultrasound</subject><subject>Viscoelasticity</subject><subject>Viscosity</subject><subject>Viscosity measurements</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LwzAcBvAgipvTg19AelShmrdm61HGfIGJHvTgKfybJq7SNjNpN_btzWgdgugpJPnlSfIgdErwFSFkck2u-DjlPGV7aEj5mMWc4nQfDTFOeUw5TgboyPsPjLFgCT5EA8qSRKSUDdHbzDdFBU1Rv0fNQkerwiurSwirKqps3patj6yJIOw6W2Vh1vothjpqy8aBt3WQfqHBxWtY6QiWS2dBLY7RgYHS65N-HKHX29nL9D6eP909TG_mseJJymIGCc6IyijmAGMqlBGcQ5oznBNmQGcTbBjmaiKAqMRgBkwbDoJAJrQhnI3QeZcbrv1stW9kFf6gyxJqbVsvCaOcpZQKGuhFR5Wz3jtt5NKFz7uNJFhum5RE9k0Ge9bHtlml8538ri6AuAProtSbv5Pk43MfeNl5r4omFG7r3ZmVdT_8Mjf_4d9P_QJYcpiX</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Huang, Chih-Chung</creator><creator>Chen, Pay-Yu</creator><creator>Shih, Cho-Chiang</creator><general>American Association of Physicists in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Estimating the viscoelastic modulus of a thrombus using an ultrasonic shear-wave approach</title><author>Huang, Chih-Chung ; Chen, Pay-Yu ; Shih, Cho-Chiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4593-3a50b1cb204aa726cf644a9d30d13faeb80f304c86a1c5f03a3ef4a61ab6ef143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Biological effects of acoustic and ultrasonic energy</topic><topic>biomechanics</topic><topic>biomedical measurement</topic><topic>biomedical ultrasonics</topic><topic>blood</topic><topic>Blood Coagulation</topic><topic>blood vessels</topic><topic>Blood Viscosity</topic><topic>Diagnosis using ultrasonic, sonic or infrasonic waves</topic><topic>Diseases</topic><topic>Elastic moduli</topic><topic>Elastic Modulus</topic><topic>elastic waves</topic><topic>elasticity</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Fluid mechanics and rheology</topic><topic>gelatin</topic><topic>haemorheology</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Measuring for diagnostic purposes; Identification of persons</topic><topic>Mechanical and electrical properties of tissues and organs</topic><topic>medical disorders</topic><topic>phantoms</topic><topic>Probability theory, stochastic processes, and statistics</topic><topic>Reproducibility of Results</topic><topic>Rheometry</topic><topic>Sensitivity and Specificity</topic><topic>shear modulus</topic><topic>Shear rate dependent viscosity</topic><topic>Shear Strength</topic><topic>shear wave</topic><topic>statistical analysis</topic><topic>Swine</topic><topic>Thrombosis - blood</topic><topic>Thrombosis - diagnostic imaging</topic><topic>Thrombosis - physiopathology</topic><topic>thrombus</topic><topic>Transducers</topic><topic>Ultrasonic transducers</topic><topic>Ultrasonography</topic><topic>ultrasound</topic><topic>Viscoelasticity</topic><topic>Viscosity</topic><topic>Viscosity measurements</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Chih-Chung</creatorcontrib><creatorcontrib>Chen, Pay-Yu</creatorcontrib><creatorcontrib>Shih, Cho-Chiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Chih-Chung</au><au>Chen, Pay-Yu</au><au>Shih, Cho-Chiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimating the viscoelastic modulus of a thrombus using an ultrasonic shear-wave approach</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2013-04</date><risdate>2013</risdate><volume>40</volume><issue>4</issue><spage>042901</spage><epage>n/a</epage><pages>042901-n/a</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><coden>MPHYA6</coden><abstract>Purpose:
Measurements of the viscoelastic properties of a thrombus can be used to assess whether blood clots are likely to become occlusive or to break apart and leak into the blood circulation and block smaller vessels. An accurate method for estimating both the shear elasticity and viscosity of a blood clotin vivo is still lacking, which prompted us to use a novel shear-wave approach to measure the viscoelastic modulus of blood clots.
Methods:
The shear-wave dispersion ultrasound vibrometry was used to measure both the elasticity and viscosity of blood clots. The experimental system was verified by measuring the viscoelastic modulus of phantoms containing gelatin at different concentrations. Blood-clot experiments were carried out using porcine whole blood with hematocrits ranging from 3% to 40%. The measured values for both clots and gelatin phantoms were compared to those obtained using an embedded-sphere method in order to validate the accuracy of the viscoelastic modulus estimations.
Results:
The shear elastic modulus increased from 406.9 ± 15.8 (mean ± SD) Pa for 3% gelatin to 1587.2 ± 28.9 Pa for 7% gelatin, while the viscosity increased from 0.12 ± 0.02 Pa s to 0.86 ± 0.05 Pa s, respectively. The shear modulus increased from 196.8 ± 58.4 Pa for 40%-hematocrit clots to 641.4 ± 76.3 Pa for 3%-hematocrit clots, while the viscosity increased from 0.29 ± 0.02 Pa s to 0.42 ± 0.01 Pa s, respectively.
Conclusions:
The results from the statistical analysis indicated that both the embedded-sphere and shear-wave approaches can provide accurate estimations of the shear elasticity for clots and gelatin phantoms. In contrast, the shear-wave approach as well as other methods of rheological measurements does not provide accurate viscosity estimations for blood clots. However, the measured viscosity range of 0.29–0.42 Pa s is reasonable for blood clots.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>23556923</pmid><doi>10.1118/1.4794493</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Algorithms Animals Biological effects of acoustic and ultrasonic energy biomechanics biomedical measurement biomedical ultrasonics blood Blood Coagulation blood vessels Blood Viscosity Diagnosis using ultrasonic, sonic or infrasonic waves Diseases Elastic moduli Elastic Modulus elastic waves elasticity Elasticity Imaging Techniques - methods Fluid mechanics and rheology gelatin haemorheology Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Measuring for diagnostic purposes Identification of persons Mechanical and electrical properties of tissues and organs medical disorders phantoms Probability theory, stochastic processes, and statistics Reproducibility of Results Rheometry Sensitivity and Specificity shear modulus Shear rate dependent viscosity Shear Strength shear wave statistical analysis Swine Thrombosis - blood Thrombosis - diagnostic imaging Thrombosis - physiopathology thrombus Transducers Ultrasonic transducers Ultrasonography ultrasound Viscoelasticity Viscosity Viscosity measurements |
| title | Estimating the viscoelastic modulus of a thrombus using an ultrasonic shear-wave approach |
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