Comparative Study of the Effectiveness of Lenampicillin and Bacampicillin on Bacterial Pneumonia by Double Blind Method
The clinical efficacy and safety of Lenamicillin (KBT-1585, LAPC) were compared with those of Bacampicillin (BAPC) as the control drug in patients with bacterial pneumonia by double blind study. Patients over 16 years old with apparent clinical signs and symptoms of pneumonia were administered LAPC...
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| Veröffentlicht in: | Kansenshogaku Zasshi 1985/06/20, Vol.59(6), pp.605-638 |
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| creator | MIKI, Fumio YOSIYAMA, Minoru MURATA, Tetsuto TANIZAWA, Shin-ichi SAKAMOTO, Kazuo SAKAI, Hirozumi SAITO, Akira TOMIZAWA, Masumi UJIIE, Akira MASUDA, Mitsuo MURAKAMI, Seiichi OSONOI, Takeshi KONNO, Kiyoshi AONUMA, Seiichi NAGAI, Kosaku YOSHIDA, Tsukasa SATO, Kazuo HAYASHI, Izumi IKEMOTO, Hideo WATANABE, Kazuyoshi IIJIMA, Fukuo SHIMADA, Kaoru OGIHARA, Hiroharu HIGASHI, Fuyuhiko SEKIMOTO, Toshio KAWAI, Takeshi AJISAWA, Atsushi MIYAJI, Hayato MURAYAMA, Yumiko MASHIMO, Keimei ITO, Chizuru TANIMOTO, Hiroichi YOSHIMURA, Kunihiko CHONABAYASI, Naohiko NAKATANI, Tatsuo KABE, Junzaburo SANO, Yasuyuki FUJIMORI, Ippei KOBAYASHI, Yoshio NAKAMURA, Yasushi MATSUMOTO, Fumio FUKAYA, Kazufuto ODAGIRI, Shigeki IKEDA, Hirotada NOSE, Keinosuke MUROHASHI, Kou WATANABE, Shin-ichiro TAKEDA, Hajimu WADA, Koichi KABASAWA, Tomoko YAMASAKU, Fusanosuke SUZUKI, Yasutoshi SEKINE, Osamu OYAMA, Kaoru TAKEUCHI, Toshihiko KATO, Masahito HANAKI, Hidekazu USAMI, Ikuji NAGASAKA, Hirohiko ITO, Tsuyoshi KUROKI, Hideaki YAMAMOTO, Toshiyuki MAEKAWA, Nobuo NAKANISHI, Michiyasu NISHIYAMA, Hideki YAMAMOTO, Takayoshi TSUJINO, Hiroyuki MIKAMI, Riichiro SAWAKI, Masayoshi OKAMOTO, Yuruko IIDA, Yube OKUBO, Hiroshi UEDA, Yoshihiro NISHIMOTO, Yukio KAMITSUNA, Akimitsu NAKANISHI, Shigekiyo YAMAKIDO, Michio NOUMI, Kazumasa KURIMURA, Osamu TAMURA, Masakazu TANI, Kenji SAWAE, Yoshiro OKADA, Kaoru HARA, Kohei YAMAGUCHI, Keizo SUZUYAMA, Yoji OKUNO, Kazuhiro OKA, Rokushi MATSUMOTO, Keizo HAYASHI, Masato ZAYASU, Kiyoshi ANDO, Masayuki FUKUDA, Yasutsugu TOKUNAGA, Katsumasa SHIMA, Kiyoshi ITOGA, Takashi NASU, Masaru GOTO, Yoichiro TASHIRO, Takayoshi NAKATOMI, Masao |
| description | The clinical efficacy and safety of Lenamicillin (KBT-1585, LAPC) were compared with those of Bacampicillin (BAPC) as the control drug in patients with bacterial pneumonia by double blind study. Patients over 16 years old with apparent clinical signs and symptoms of pneumonia were administered LAPC (at a daily dose of 1 g) or BAPC (at a daily dose of 1 g) orally for 14 days in principle. Then the clinical and bacteriological efficacy, improvement in symptoms, side effects, abnormal changes in laboratory findings, and utility were assessed. After excluding the patients which did not fit the protocol from the total 209 patients admitted to the study, clinical efficacy, side effects and abnormal changes in laboratory findings were analyzed statistically in 187 patients, in 199 and in 193 patients respectively. Basides, clinical efficacy was analyzed in the patients with bacterial pneumonia which were completely adapted to the protocol and also in the total patients including those with non-bacterial pneumonia and other respiratory tract infections. 1) On the basis of committee judgement, the clinical efficacy rate in the patients with bacterial pneumonia was 86.9% for the LAPC group and 86.7% for the BAPC group, respectively. As for the total cases, the rate was 80.2% for the LAPC group and 85.4% for the BAPC group, respectively. In both analyses, no significant differences were found between the two groups. 2) According to the judgement by doctors in charge, the clinical efficacy rate in the patients with bacterial pneumonia was 90.0% for the LAPC group and 84.0% for the BAPC group, respectively. As for the total cases, the efficacy rate was 81.6% for the LAPC group and 81.7% for the BAPC group, respectively. In both analyses, there were no significant differences between the two groups. 3) As for the bacteriological efficacy, there was no significant difference between the two groups. 4) The incidence of side effects was 4.1% in the LAPC group and 7.8% in the BAPC group, respectively. The incidence of the abnormal changes in laboratory findigs was 19.4% for the LAPC group and 22.0% for the BAPC group, respectively. There was no significant difference between the two groups. 5) The utility rate in the patients with bacterial pneumonia judged by the committee was 86.9% for the LAPC group and 80.0% for the BAPC group, respectively. The rate in the total cases was 80.2% for the LAPC group and 79.2% for the BAPC group. No significant differences between the two |
| doi_str_mv | 10.11150/kansenshogakuzasshi1970.59.605 |
| format | Article |
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YOSIYAMA, Minoru ; MURATA, Tetsuto ; TANIZAWA, Shin-ichi ; SAKAMOTO, Kazuo ; SAKAI, Hirozumi ; SAITO, Akira ; TOMIZAWA, Masumi ; UJIIE, Akira ; MASUDA, Mitsuo ; MURAKAMI, Seiichi ; OSONOI, Takeshi ; KONNO, Kiyoshi ; AONUMA, Seiichi ; NAGAI, Kosaku ; YOSHIDA, Tsukasa ; SATO, Kazuo ; HAYASHI, Izumi ; IKEMOTO, Hideo ; WATANABE, Kazuyoshi ; IIJIMA, Fukuo ; SHIMADA, Kaoru ; OGIHARA, Hiroharu ; HIGASHI, Fuyuhiko ; SEKIMOTO, Toshio ; KAWAI, Takeshi ; AJISAWA, Atsushi ; MIYAJI, Hayato ; MURAYAMA, Yumiko ; MASHIMO, Keimei ; ITO, Chizuru ; TANIMOTO, Hiroichi ; YOSHIMURA, Kunihiko ; CHONABAYASI, Naohiko ; NAKATANI, Tatsuo ; KABE, Junzaburo ; SANO, Yasuyuki ; FUJIMORI, Ippei ; KOBAYASHI, Yoshio ; NAKAMURA, Yasushi ; MATSUMOTO, Fumio ; FUKAYA, Kazufuto ; ODAGIRI, Shigeki ; IKEDA, Hirotada ; NOSE, Keinosuke ; MUROHASHI, Kou ; WATANABE, Shin-ichiro ; TAKEDA, Hajimu ; WADA, Koichi ; KABASAWA, Tomoko ; YAMASAKU, Fusanosuke ; SUZUKI, Yasutoshi ; SEKINE, Osamu ; OYAMA, Kaoru ; TAKEUCHI, Toshihiko ; KATO, Masahito ; HANAKI, Hidekazu ; USAMI, Ikuji ; NAGASAKA, Hirohiko ; ITO, Tsuyoshi ; KUROKI, Hideaki ; YAMAMOTO, Toshiyuki ; MAEKAWA, Nobuo ; NAKANISHI, Michiyasu ; NISHIYAMA, Hideki ; YAMAMOTO, Takayoshi ; TSUJINO, Hiroyuki ; MIKAMI, Riichiro ; SAWAKI, Masayoshi ; OKAMOTO, Yuruko ; IIDA, Yube ; OKUBO, Hiroshi ; UEDA, Yoshihiro ; NISHIMOTO, Yukio ; KAMITSUNA, Akimitsu ; NAKANISHI, Shigekiyo ; YAMAKIDO, Michio ; NOUMI, Kazumasa ; KURIMURA, Osamu ; TAMURA, Masakazu ; TANI, Kenji ; SAWAE, Yoshiro ; OKADA, Kaoru ; HARA, Kohei ; YAMAGUCHI, Keizo ; SUZUYAMA, Yoji ; OKUNO, Kazuhiro ; OKA, Rokushi ; MATSUMOTO, Keizo ; HAYASHI, Masato ; ZAYASU, Kiyoshi ; ANDO, Masayuki ; FUKUDA, Yasutsugu ; TOKUNAGA, Katsumasa ; SHIMA, Kiyoshi ; ITOGA, Takashi ; NASU, Masaru ; GOTO, Yoichiro ; TASHIRO, Takayoshi ; NAKATOMI, Masao</creator><creatorcontrib>MIKI, Fumio ; YOSIYAMA, Minoru ; MURATA, Tetsuto ; TANIZAWA, Shin-ichi ; SAKAMOTO, Kazuo ; SAKAI, Hirozumi ; SAITO, Akira ; TOMIZAWA, Masumi ; UJIIE, Akira ; MASUDA, Mitsuo ; MURAKAMI, Seiichi ; OSONOI, Takeshi ; KONNO, Kiyoshi ; AONUMA, Seiichi ; NAGAI, Kosaku ; YOSHIDA, Tsukasa ; SATO, Kazuo ; HAYASHI, Izumi ; IKEMOTO, Hideo ; WATANABE, Kazuyoshi ; IIJIMA, Fukuo ; SHIMADA, Kaoru ; OGIHARA, Hiroharu ; HIGASHI, Fuyuhiko ; SEKIMOTO, Toshio ; KAWAI, Takeshi ; AJISAWA, Atsushi ; MIYAJI, Hayato ; MURAYAMA, Yumiko ; MASHIMO, Keimei ; ITO, Chizuru ; TANIMOTO, Hiroichi ; YOSHIMURA, Kunihiko ; CHONABAYASI, Naohiko ; NAKATANI, Tatsuo ; KABE, Junzaburo ; SANO, Yasuyuki ; FUJIMORI, Ippei ; KOBAYASHI, Yoshio ; NAKAMURA, Yasushi ; MATSUMOTO, Fumio ; FUKAYA, Kazufuto ; ODAGIRI, Shigeki ; IKEDA, Hirotada ; NOSE, Keinosuke ; MUROHASHI, Kou ; WATANABE, Shin-ichiro ; TAKEDA, Hajimu ; WADA, Koichi ; KABASAWA, Tomoko ; YAMASAKU, Fusanosuke ; SUZUKI, Yasutoshi ; SEKINE, Osamu ; OYAMA, Kaoru ; TAKEUCHI, Toshihiko ; KATO, Masahito ; HANAKI, Hidekazu ; USAMI, Ikuji ; NAGASAKA, Hirohiko ; ITO, Tsuyoshi ; KUROKI, Hideaki ; YAMAMOTO, Toshiyuki ; MAEKAWA, Nobuo ; NAKANISHI, Michiyasu ; NISHIYAMA, Hideki ; YAMAMOTO, Takayoshi ; TSUJINO, Hiroyuki ; MIKAMI, Riichiro ; SAWAKI, Masayoshi ; OKAMOTO, Yuruko ; IIDA, Yube ; OKUBO, Hiroshi ; UEDA, Yoshihiro ; NISHIMOTO, Yukio ; KAMITSUNA, Akimitsu ; NAKANISHI, Shigekiyo ; YAMAKIDO, Michio ; NOUMI, Kazumasa ; KURIMURA, Osamu ; TAMURA, Masakazu ; TANI, Kenji ; SAWAE, Yoshiro ; OKADA, Kaoru ; HARA, Kohei ; YAMAGUCHI, Keizo ; SUZUYAMA, Yoji ; OKUNO, Kazuhiro ; OKA, Rokushi ; MATSUMOTO, Keizo ; HAYASHI, Masato ; ZAYASU, Kiyoshi ; ANDO, Masayuki ; FUKUDA, Yasutsugu ; TOKUNAGA, Katsumasa ; SHIMA, Kiyoshi ; ITOGA, Takashi ; NASU, Masaru ; GOTO, Yoichiro ; TASHIRO, Takayoshi ; NAKATOMI, Masao</creatorcontrib><description>The clinical efficacy and safety of Lenamicillin (KBT-1585, LAPC) were compared with those of Bacampicillin (BAPC) as the control drug in patients with bacterial pneumonia by double blind study. Patients over 16 years old with apparent clinical signs and symptoms of pneumonia were administered LAPC (at a daily dose of 1 g) or BAPC (at a daily dose of 1 g) orally for 14 days in principle. Then the clinical and bacteriological efficacy, improvement in symptoms, side effects, abnormal changes in laboratory findings, and utility were assessed. After excluding the patients which did not fit the protocol from the total 209 patients admitted to the study, clinical efficacy, side effects and abnormal changes in laboratory findings were analyzed statistically in 187 patients, in 199 and in 193 patients respectively. Basides, clinical efficacy was analyzed in the patients with bacterial pneumonia which were completely adapted to the protocol and also in the total patients including those with non-bacterial pneumonia and other respiratory tract infections. 1) On the basis of committee judgement, the clinical efficacy rate in the patients with bacterial pneumonia was 86.9% for the LAPC group and 86.7% for the BAPC group, respectively. As for the total cases, the rate was 80.2% for the LAPC group and 85.4% for the BAPC group, respectively. In both analyses, no significant differences were found between the two groups. 2) According to the judgement by doctors in charge, the clinical efficacy rate in the patients with bacterial pneumonia was 90.0% for the LAPC group and 84.0% for the BAPC group, respectively. As for the total cases, the efficacy rate was 81.6% for the LAPC group and 81.7% for the BAPC group, respectively. In both analyses, there were no significant differences between the two groups. 3) As for the bacteriological efficacy, there was no significant difference between the two groups. 4) The incidence of side effects was 4.1% in the LAPC group and 7.8% in the BAPC group, respectively. The incidence of the abnormal changes in laboratory findigs was 19.4% for the LAPC group and 22.0% for the BAPC group, respectively. There was no significant difference between the two groups. 5) The utility rate in the patients with bacterial pneumonia judged by the committee was 86.9% for the LAPC group and 80.0% for the BAPC group, respectively. The rate in the total cases was 80.2% for the LAPC group and 79.2% for the BAPC group. No significant differences between the two groups were noted. In the utility rate judged by doctors in charge, no significant difference was found between the two groups, too. As described above, any significant differences were found between LAPC (at a daily dose of 1 g) and BAPC (at a daily dose of 1 g) neither in the efficacy rates nor in their safety. From these results, LAPC as well as BAPC are considered to be highly useful antibacterial agents for the treatment of respiratory tract infections.</description><identifier>ISSN: 0387-5911</identifier><identifier>EISSN: 1884-569X</identifier><identifier>DOI: 10.11150/kansenshogakuzasshi1970.59.605</identifier><identifier>PMID: 3932547</identifier><language>eng ; jpn</language><publisher>Japan: The Japanese Association for Infectious Diseases</publisher><subject>Adolescent ; Adult ; Aged ; Ampicillin - administration & dosage ; Ampicillin - adverse effects ; Ampicillin - analogs & derivatives ; Ampicillin - therapeutic use ; Bacampicillin ; Clinical Trials as Topic ; Combarative Study ; Double-Blind Method ; Female ; Humans ; KBT-1585 ; LAPC ; Lenampicillin ; Male ; Middle Aged ; Pneumonia ; Pneumonia - drug therapy ; Pneumonia - microbiology</subject><ispartof>Kansenshogaku Zasshi, 1985/06/20, Vol.59(6), pp.605-638</ispartof><rights>The Japansese Association for Infectious Diseases</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3932547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIKI, Fumio</creatorcontrib><creatorcontrib>YOSIYAMA, Minoru</creatorcontrib><creatorcontrib>MURATA, Tetsuto</creatorcontrib><creatorcontrib>TANIZAWA, Shin-ichi</creatorcontrib><creatorcontrib>SAKAMOTO, Kazuo</creatorcontrib><creatorcontrib>SAKAI, Hirozumi</creatorcontrib><creatorcontrib>SAITO, Akira</creatorcontrib><creatorcontrib>TOMIZAWA, Masumi</creatorcontrib><creatorcontrib>UJIIE, Akira</creatorcontrib><creatorcontrib>MASUDA, Mitsuo</creatorcontrib><creatorcontrib>MURAKAMI, Seiichi</creatorcontrib><creatorcontrib>OSONOI, Takeshi</creatorcontrib><creatorcontrib>KONNO, Kiyoshi</creatorcontrib><creatorcontrib>AONUMA, Seiichi</creatorcontrib><creatorcontrib>NAGAI, Kosaku</creatorcontrib><creatorcontrib>YOSHIDA, Tsukasa</creatorcontrib><creatorcontrib>SATO, Kazuo</creatorcontrib><creatorcontrib>HAYASHI, Izumi</creatorcontrib><creatorcontrib>IKEMOTO, Hideo</creatorcontrib><creatorcontrib>WATANABE, Kazuyoshi</creatorcontrib><creatorcontrib>IIJIMA, Fukuo</creatorcontrib><creatorcontrib>SHIMADA, Kaoru</creatorcontrib><creatorcontrib>OGIHARA, Hiroharu</creatorcontrib><creatorcontrib>HIGASHI, Fuyuhiko</creatorcontrib><creatorcontrib>SEKIMOTO, Toshio</creatorcontrib><creatorcontrib>KAWAI, Takeshi</creatorcontrib><creatorcontrib>AJISAWA, Atsushi</creatorcontrib><creatorcontrib>MIYAJI, Hayato</creatorcontrib><creatorcontrib>MURAYAMA, Yumiko</creatorcontrib><creatorcontrib>MASHIMO, Keimei</creatorcontrib><creatorcontrib>ITO, Chizuru</creatorcontrib><creatorcontrib>TANIMOTO, Hiroichi</creatorcontrib><creatorcontrib>YOSHIMURA, Kunihiko</creatorcontrib><creatorcontrib>CHONABAYASI, Naohiko</creatorcontrib><creatorcontrib>NAKATANI, Tatsuo</creatorcontrib><creatorcontrib>KABE, Junzaburo</creatorcontrib><creatorcontrib>SANO, Yasuyuki</creatorcontrib><creatorcontrib>FUJIMORI, Ippei</creatorcontrib><creatorcontrib>KOBAYASHI, Yoshio</creatorcontrib><creatorcontrib>NAKAMURA, Yasushi</creatorcontrib><creatorcontrib>MATSUMOTO, Fumio</creatorcontrib><creatorcontrib>FUKAYA, Kazufuto</creatorcontrib><creatorcontrib>ODAGIRI, Shigeki</creatorcontrib><creatorcontrib>IKEDA, Hirotada</creatorcontrib><creatorcontrib>NOSE, Keinosuke</creatorcontrib><creatorcontrib>MUROHASHI, Kou</creatorcontrib><creatorcontrib>WATANABE, Shin-ichiro</creatorcontrib><creatorcontrib>TAKEDA, Hajimu</creatorcontrib><creatorcontrib>WADA, Koichi</creatorcontrib><creatorcontrib>KABASAWA, Tomoko</creatorcontrib><creatorcontrib>YAMASAKU, Fusanosuke</creatorcontrib><creatorcontrib>SUZUKI, Yasutoshi</creatorcontrib><creatorcontrib>SEKINE, Osamu</creatorcontrib><creatorcontrib>OYAMA, Kaoru</creatorcontrib><creatorcontrib>TAKEUCHI, Toshihiko</creatorcontrib><creatorcontrib>KATO, Masahito</creatorcontrib><creatorcontrib>HANAKI, Hidekazu</creatorcontrib><creatorcontrib>USAMI, Ikuji</creatorcontrib><creatorcontrib>NAGASAKA, Hirohiko</creatorcontrib><creatorcontrib>ITO, Tsuyoshi</creatorcontrib><creatorcontrib>KUROKI, Hideaki</creatorcontrib><creatorcontrib>YAMAMOTO, Toshiyuki</creatorcontrib><creatorcontrib>MAEKAWA, Nobuo</creatorcontrib><creatorcontrib>NAKANISHI, Michiyasu</creatorcontrib><creatorcontrib>NISHIYAMA, Hideki</creatorcontrib><creatorcontrib>YAMAMOTO, Takayoshi</creatorcontrib><creatorcontrib>TSUJINO, Hiroyuki</creatorcontrib><creatorcontrib>MIKAMI, Riichiro</creatorcontrib><creatorcontrib>SAWAKI, Masayoshi</creatorcontrib><creatorcontrib>OKAMOTO, Yuruko</creatorcontrib><creatorcontrib>IIDA, Yube</creatorcontrib><creatorcontrib>OKUBO, Hiroshi</creatorcontrib><creatorcontrib>UEDA, Yoshihiro</creatorcontrib><creatorcontrib>NISHIMOTO, Yukio</creatorcontrib><creatorcontrib>KAMITSUNA, Akimitsu</creatorcontrib><creatorcontrib>NAKANISHI, Shigekiyo</creatorcontrib><creatorcontrib>YAMAKIDO, Michio</creatorcontrib><creatorcontrib>NOUMI, Kazumasa</creatorcontrib><creatorcontrib>KURIMURA, Osamu</creatorcontrib><creatorcontrib>TAMURA, Masakazu</creatorcontrib><creatorcontrib>TANI, Kenji</creatorcontrib><creatorcontrib>SAWAE, Yoshiro</creatorcontrib><creatorcontrib>OKADA, Kaoru</creatorcontrib><creatorcontrib>HARA, Kohei</creatorcontrib><creatorcontrib>YAMAGUCHI, Keizo</creatorcontrib><creatorcontrib>SUZUYAMA, Yoji</creatorcontrib><creatorcontrib>OKUNO, Kazuhiro</creatorcontrib><creatorcontrib>OKA, Rokushi</creatorcontrib><creatorcontrib>MATSUMOTO, Keizo</creatorcontrib><creatorcontrib>HAYASHI, Masato</creatorcontrib><creatorcontrib>ZAYASU, Kiyoshi</creatorcontrib><creatorcontrib>ANDO, Masayuki</creatorcontrib><creatorcontrib>FUKUDA, Yasutsugu</creatorcontrib><creatorcontrib>TOKUNAGA, Katsumasa</creatorcontrib><creatorcontrib>SHIMA, Kiyoshi</creatorcontrib><creatorcontrib>ITOGA, Takashi</creatorcontrib><creatorcontrib>NASU, Masaru</creatorcontrib><creatorcontrib>GOTO, Yoichiro</creatorcontrib><creatorcontrib>TASHIRO, Takayoshi</creatorcontrib><creatorcontrib>NAKATOMI, Masao</creatorcontrib><title>Comparative Study of the Effectiveness of Lenampicillin and Bacampicillin on Bacterial Pneumonia by Double Blind Method</title><title>Kansenshogaku Zasshi</title><addtitle>J. J. A. Inf. D</addtitle><description>The clinical efficacy and safety of Lenamicillin (KBT-1585, LAPC) were compared with those of Bacampicillin (BAPC) as the control drug in patients with bacterial pneumonia by double blind study. Patients over 16 years old with apparent clinical signs and symptoms of pneumonia were administered LAPC (at a daily dose of 1 g) or BAPC (at a daily dose of 1 g) orally for 14 days in principle. Then the clinical and bacteriological efficacy, improvement in symptoms, side effects, abnormal changes in laboratory findings, and utility were assessed. After excluding the patients which did not fit the protocol from the total 209 patients admitted to the study, clinical efficacy, side effects and abnormal changes in laboratory findings were analyzed statistically in 187 patients, in 199 and in 193 patients respectively. Basides, clinical efficacy was analyzed in the patients with bacterial pneumonia which were completely adapted to the protocol and also in the total patients including those with non-bacterial pneumonia and other respiratory tract infections. 1) On the basis of committee judgement, the clinical efficacy rate in the patients with bacterial pneumonia was 86.9% for the LAPC group and 86.7% for the BAPC group, respectively. As for the total cases, the rate was 80.2% for the LAPC group and 85.4% for the BAPC group, respectively. In both analyses, no significant differences were found between the two groups. 2) According to the judgement by doctors in charge, the clinical efficacy rate in the patients with bacterial pneumonia was 90.0% for the LAPC group and 84.0% for the BAPC group, respectively. As for the total cases, the efficacy rate was 81.6% for the LAPC group and 81.7% for the BAPC group, respectively. In both analyses, there were no significant differences between the two groups. 3) As for the bacteriological efficacy, there was no significant difference between the two groups. 4) The incidence of side effects was 4.1% in the LAPC group and 7.8% in the BAPC group, respectively. The incidence of the abnormal changes in laboratory findigs was 19.4% for the LAPC group and 22.0% for the BAPC group, respectively. There was no significant difference between the two groups. 5) The utility rate in the patients with bacterial pneumonia judged by the committee was 86.9% for the LAPC group and 80.0% for the BAPC group, respectively. The rate in the total cases was 80.2% for the LAPC group and 79.2% for the BAPC group. No significant differences between the two groups were noted. In the utility rate judged by doctors in charge, no significant difference was found between the two groups, too. As described above, any significant differences were found between LAPC (at a daily dose of 1 g) and BAPC (at a daily dose of 1 g) neither in the efficacy rates nor in their safety. From these results, LAPC as well as BAPC are considered to be highly useful antibacterial agents for the treatment of respiratory tract infections.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Ampicillin - administration & dosage</subject><subject>Ampicillin - adverse effects</subject><subject>Ampicillin - analogs & derivatives</subject><subject>Ampicillin - therapeutic use</subject><subject>Bacampicillin</subject><subject>Clinical Trials as Topic</subject><subject>Combarative Study</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>KBT-1585</subject><subject>LAPC</subject><subject>Lenampicillin</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pneumonia</subject><subject>Pneumonia - drug therapy</subject><subject>Pneumonia - microbiology</subject><issn>0387-5911</issn><issn>1884-569X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMouqgfQcjNU9ck3bTNSXRd_8CKggreymSa2GibLk2rrJ_eriuLF73MwHtvfgOPkGPOxpxzyU7ewAfjQ9m8wFv_CSGUjquUjaUaJ0xukRHPskkkE_W8TUYsztJIKs73yGEITjPG1IQJKXbJbqxiISfpiHxMm3oBLXTu3dCHri-WtLG0Kw2dWWtwJXsTwkqcGw_1wqGrKucp-IKeA_5SGr8SOtM6qOi9N33deAdUL-lF0-vK0PMhVdBb05VNcUB2LFTBHP7sffJ0OXucXkfzu6ub6dk8QpEqGUGqxUQIC4XAOEVVJFls40RzqRlyRNSJRQ2ZQqYQGWQ6FQhJwrRNtJJFvE9O11xsmxBaY_NF62polzln-Xep-R-l5lLlQ6kD4WhNWPS6NsXm_qfCwX9Y-6-hgxez8aHtHFbmX_x6DF82aSyhzY2PvwCn95xT</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>MIKI, Fumio</creator><creator>YOSIYAMA, Minoru</creator><creator>MURATA, Tetsuto</creator><creator>TANIZAWA, Shin-ichi</creator><creator>SAKAMOTO, Kazuo</creator><creator>SAKAI, Hirozumi</creator><creator>SAITO, Akira</creator><creator>TOMIZAWA, Masumi</creator><creator>UJIIE, Akira</creator><creator>MASUDA, Mitsuo</creator><creator>MURAKAMI, Seiichi</creator><creator>OSONOI, Takeshi</creator><creator>KONNO, Kiyoshi</creator><creator>AONUMA, Seiichi</creator><creator>NAGAI, Kosaku</creator><creator>YOSHIDA, Tsukasa</creator><creator>SATO, Kazuo</creator><creator>HAYASHI, Izumi</creator><creator>IKEMOTO, Hideo</creator><creator>WATANABE, Kazuyoshi</creator><creator>IIJIMA, Fukuo</creator><creator>SHIMADA, Kaoru</creator><creator>OGIHARA, Hiroharu</creator><creator>HIGASHI, Fuyuhiko</creator><creator>SEKIMOTO, Toshio</creator><creator>KAWAI, Takeshi</creator><creator>AJISAWA, Atsushi</creator><creator>MIYAJI, Hayato</creator><creator>MURAYAMA, Yumiko</creator><creator>MASHIMO, Keimei</creator><creator>ITO, Chizuru</creator><creator>TANIMOTO, Hiroichi</creator><creator>YOSHIMURA, Kunihiko</creator><creator>CHONABAYASI, Naohiko</creator><creator>NAKATANI, Tatsuo</creator><creator>KABE, Junzaburo</creator><creator>SANO, 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Hideki</creator><creator>YAMAMOTO, Takayoshi</creator><creator>TSUJINO, Hiroyuki</creator><creator>MIKAMI, Riichiro</creator><creator>SAWAKI, Masayoshi</creator><creator>OKAMOTO, Yuruko</creator><creator>IIDA, Yube</creator><creator>OKUBO, Hiroshi</creator><creator>UEDA, Yoshihiro</creator><creator>NISHIMOTO, Yukio</creator><creator>KAMITSUNA, Akimitsu</creator><creator>NAKANISHI, Shigekiyo</creator><creator>YAMAKIDO, Michio</creator><creator>NOUMI, Kazumasa</creator><creator>KURIMURA, Osamu</creator><creator>TAMURA, Masakazu</creator><creator>TANI, Kenji</creator><creator>SAWAE, Yoshiro</creator><creator>OKADA, Kaoru</creator><creator>HARA, Kohei</creator><creator>YAMAGUCHI, Keizo</creator><creator>SUZUYAMA, Yoji</creator><creator>OKUNO, Kazuhiro</creator><creator>OKA, Rokushi</creator><creator>MATSUMOTO, Keizo</creator><creator>HAYASHI, Masato</creator><creator>ZAYASU, Kiyoshi</creator><creator>ANDO, Masayuki</creator><creator>FUKUDA, Yasutsugu</creator><creator>TOKUNAGA, Katsumasa</creator><creator>SHIMA, Kiyoshi</creator><creator>ITOGA, Takashi</creator><creator>NASU, Masaru</creator><creator>GOTO, Yoichiro</creator><creator>TASHIRO, Takayoshi</creator><creator>NAKATOMI, Masao</creator><general>The Japanese Association for Infectious Diseases</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1985</creationdate><title>Comparative Study of the Effectiveness of Lenampicillin and Bacampicillin on Bacterial Pneumonia by Double Blind Method</title><author>MIKI, Fumio ; YOSIYAMA, Minoru ; MURATA, Tetsuto ; TANIZAWA, Shin-ichi ; SAKAMOTO, Kazuo ; SAKAI, Hirozumi ; SAITO, Akira ; TOMIZAWA, Masumi ; UJIIE, Akira ; MASUDA, Mitsuo ; MURAKAMI, Seiichi ; OSONOI, Takeshi ; KONNO, Kiyoshi ; AONUMA, Seiichi ; NAGAI, Kosaku ; YOSHIDA, Tsukasa ; SATO, Kazuo ; HAYASHI, Izumi ; IKEMOTO, Hideo ; WATANABE, Kazuyoshi ; IIJIMA, Fukuo ; SHIMADA, Kaoru ; OGIHARA, Hiroharu ; HIGASHI, Fuyuhiko ; SEKIMOTO, Toshio ; KAWAI, Takeshi ; AJISAWA, Atsushi ; MIYAJI, Hayato ; MURAYAMA, Yumiko ; MASHIMO, Keimei ; ITO, Chizuru ; TANIMOTO, Hiroichi ; YOSHIMURA, Kunihiko ; CHONABAYASI, Naohiko ; NAKATANI, Tatsuo ; KABE, Junzaburo ; SANO, Yasuyuki ; FUJIMORI, Ippei ; KOBAYASHI, Yoshio ; NAKAMURA, Yasushi ; MATSUMOTO, Fumio ; FUKAYA, Kazufuto ; ODAGIRI, Shigeki ; IKEDA, Hirotada ; NOSE, Keinosuke ; MUROHASHI, Kou ; WATANABE, Shin-ichiro ; TAKEDA, Hajimu ; WADA, Koichi ; KABASAWA, Tomoko ; YAMASAKU, Fusanosuke ; SUZUKI, Yasutoshi ; SEKINE, Osamu ; OYAMA, Kaoru ; TAKEUCHI, Toshihiko ; KATO, Masahito ; HANAKI, Hidekazu ; USAMI, Ikuji ; NAGASAKA, Hirohiko ; ITO, Tsuyoshi ; KUROKI, Hideaki ; YAMAMOTO, Toshiyuki ; MAEKAWA, Nobuo ; NAKANISHI, Michiyasu ; NISHIYAMA, Hideki ; YAMAMOTO, Takayoshi ; TSUJINO, Hiroyuki ; MIKAMI, Riichiro ; SAWAKI, Masayoshi ; OKAMOTO, Yuruko ; IIDA, Yube ; OKUBO, Hiroshi ; UEDA, Yoshihiro ; NISHIMOTO, Yukio ; KAMITSUNA, Akimitsu ; NAKANISHI, Shigekiyo ; YAMAKIDO, Michio ; NOUMI, Kazumasa ; KURIMURA, Osamu ; TAMURA, Masakazu ; TANI, Kenji ; SAWAE, Yoshiro ; OKADA, Kaoru ; HARA, Kohei ; YAMAGUCHI, Keizo ; SUZUYAMA, Yoji ; OKUNO, Kazuhiro ; OKA, Rokushi ; MATSUMOTO, Keizo ; HAYASHI, Masato ; ZAYASU, Kiyoshi ; ANDO, Masayuki ; FUKUDA, Yasutsugu ; TOKUNAGA, Katsumasa ; SHIMA, Kiyoshi ; ITOGA, Takashi ; NASU, Masaru ; GOTO, Yoichiro ; TASHIRO, Takayoshi ; NAKATOMI, Masao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2795-a7b2422fad2c37c9d683f36b15b0c1cccb6fcba89c09cc0a8b72ca660bf6b95d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1985</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Ampicillin - administration & dosage</topic><topic>Ampicillin - adverse effects</topic><topic>Ampicillin - analogs & derivatives</topic><topic>Ampicillin - therapeutic use</topic><topic>Bacampicillin</topic><topic>Clinical Trials as Topic</topic><topic>Combarative Study</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>KBT-1585</topic><topic>LAPC</topic><topic>Lenampicillin</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pneumonia</topic><topic>Pneumonia - drug therapy</topic><topic>Pneumonia - microbiology</topic><toplevel>online_resources</toplevel><creatorcontrib>MIKI, Fumio</creatorcontrib><creatorcontrib>YOSIYAMA, Minoru</creatorcontrib><creatorcontrib>MURATA, Tetsuto</creatorcontrib><creatorcontrib>TANIZAWA, Shin-ichi</creatorcontrib><creatorcontrib>SAKAMOTO, Kazuo</creatorcontrib><creatorcontrib>SAKAI, Hirozumi</creatorcontrib><creatorcontrib>SAITO, Akira</creatorcontrib><creatorcontrib>TOMIZAWA, Masumi</creatorcontrib><creatorcontrib>UJIIE, Akira</creatorcontrib><creatorcontrib>MASUDA, Mitsuo</creatorcontrib><creatorcontrib>MURAKAMI, Seiichi</creatorcontrib><creatorcontrib>OSONOI, 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Akira</au><au>MASUDA, Mitsuo</au><au>MURAKAMI, Seiichi</au><au>OSONOI, Takeshi</au><au>KONNO, Kiyoshi</au><au>AONUMA, Seiichi</au><au>NAGAI, Kosaku</au><au>YOSHIDA, Tsukasa</au><au>SATO, Kazuo</au><au>HAYASHI, Izumi</au><au>IKEMOTO, Hideo</au><au>WATANABE, Kazuyoshi</au><au>IIJIMA, Fukuo</au><au>SHIMADA, Kaoru</au><au>OGIHARA, Hiroharu</au><au>HIGASHI, Fuyuhiko</au><au>SEKIMOTO, Toshio</au><au>KAWAI, Takeshi</au><au>AJISAWA, Atsushi</au><au>MIYAJI, Hayato</au><au>MURAYAMA, Yumiko</au><au>MASHIMO, Keimei</au><au>ITO, Chizuru</au><au>TANIMOTO, Hiroichi</au><au>YOSHIMURA, Kunihiko</au><au>CHONABAYASI, Naohiko</au><au>NAKATANI, Tatsuo</au><au>KABE, Junzaburo</au><au>SANO, Yasuyuki</au><au>FUJIMORI, Ippei</au><au>KOBAYASHI, Yoshio</au><au>NAKAMURA, Yasushi</au><au>MATSUMOTO, Fumio</au><au>FUKAYA, Kazufuto</au><au>ODAGIRI, Shigeki</au><au>IKEDA, Hirotada</au><au>NOSE, Keinosuke</au><au>MUROHASHI, Kou</au><au>WATANABE, Shin-ichiro</au><au>TAKEDA, Hajimu</au><au>WADA, Koichi</au><au>KABASAWA, Tomoko</au><au>YAMASAKU, Fusanosuke</au><au>SUZUKI, Yasutoshi</au><au>SEKINE, Osamu</au><au>OYAMA, Kaoru</au><au>TAKEUCHI, Toshihiko</au><au>KATO, Masahito</au><au>HANAKI, Hidekazu</au><au>USAMI, Ikuji</au><au>NAGASAKA, Hirohiko</au><au>ITO, Tsuyoshi</au><au>KUROKI, Hideaki</au><au>YAMAMOTO, Toshiyuki</au><au>MAEKAWA, Nobuo</au><au>NAKANISHI, Michiyasu</au><au>NISHIYAMA, Hideki</au><au>YAMAMOTO, Takayoshi</au><au>TSUJINO, Hiroyuki</au><au>MIKAMI, Riichiro</au><au>SAWAKI, Masayoshi</au><au>OKAMOTO, Yuruko</au><au>IIDA, Yube</au><au>OKUBO, Hiroshi</au><au>UEDA, Yoshihiro</au><au>NISHIMOTO, Yukio</au><au>KAMITSUNA, Akimitsu</au><au>NAKANISHI, Shigekiyo</au><au>YAMAKIDO, Michio</au><au>NOUMI, Kazumasa</au><au>KURIMURA, Osamu</au><au>TAMURA, Masakazu</au><au>TANI, Kenji</au><au>SAWAE, Yoshiro</au><au>OKADA, Kaoru</au><au>HARA, Kohei</au><au>YAMAGUCHI, Keizo</au><au>SUZUYAMA, Yoji</au><au>OKUNO, Kazuhiro</au><au>OKA, Rokushi</au><au>MATSUMOTO, Keizo</au><au>HAYASHI, Masato</au><au>ZAYASU, Kiyoshi</au><au>ANDO, Masayuki</au><au>FUKUDA, Yasutsugu</au><au>TOKUNAGA, Katsumasa</au><au>SHIMA, Kiyoshi</au><au>ITOGA, Takashi</au><au>NASU, Masaru</au><au>GOTO, Yoichiro</au><au>TASHIRO, Takayoshi</au><au>NAKATOMI, Masao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Study of the Effectiveness of Lenampicillin and Bacampicillin on Bacterial Pneumonia by Double Blind Method</atitle><jtitle>Kansenshogaku Zasshi</jtitle><addtitle>J. J. A. Inf. D</addtitle><date>1985</date><risdate>1985</risdate><volume>59</volume><issue>6</issue><spage>605</spage><epage>638</epage><pages>605-638</pages><issn>0387-5911</issn><eissn>1884-569X</eissn><abstract>The clinical efficacy and safety of Lenamicillin (KBT-1585, LAPC) were compared with those of Bacampicillin (BAPC) as the control drug in patients with bacterial pneumonia by double blind study. Patients over 16 years old with apparent clinical signs and symptoms of pneumonia were administered LAPC (at a daily dose of 1 g) or BAPC (at a daily dose of 1 g) orally for 14 days in principle. Then the clinical and bacteriological efficacy, improvement in symptoms, side effects, abnormal changes in laboratory findings, and utility were assessed. After excluding the patients which did not fit the protocol from the total 209 patients admitted to the study, clinical efficacy, side effects and abnormal changes in laboratory findings were analyzed statistically in 187 patients, in 199 and in 193 patients respectively. Basides, clinical efficacy was analyzed in the patients with bacterial pneumonia which were completely adapted to the protocol and also in the total patients including those with non-bacterial pneumonia and other respiratory tract infections. 1) On the basis of committee judgement, the clinical efficacy rate in the patients with bacterial pneumonia was 86.9% for the LAPC group and 86.7% for the BAPC group, respectively. As for the total cases, the rate was 80.2% for the LAPC group and 85.4% for the BAPC group, respectively. In both analyses, no significant differences were found between the two groups. 2) According to the judgement by doctors in charge, the clinical efficacy rate in the patients with bacterial pneumonia was 90.0% for the LAPC group and 84.0% for the BAPC group, respectively. As for the total cases, the efficacy rate was 81.6% for the LAPC group and 81.7% for the BAPC group, respectively. In both analyses, there were no significant differences between the two groups. 3) As for the bacteriological efficacy, there was no significant difference between the two groups. 4) The incidence of side effects was 4.1% in the LAPC group and 7.8% in the BAPC group, respectively. The incidence of the abnormal changes in laboratory findigs was 19.4% for the LAPC group and 22.0% for the BAPC group, respectively. There was no significant difference between the two groups. 5) The utility rate in the patients with bacterial pneumonia judged by the committee was 86.9% for the LAPC group and 80.0% for the BAPC group, respectively. The rate in the total cases was 80.2% for the LAPC group and 79.2% for the BAPC group. No significant differences between the two groups were noted. In the utility rate judged by doctors in charge, no significant difference was found between the two groups, too. As described above, any significant differences were found between LAPC (at a daily dose of 1 g) and BAPC (at a daily dose of 1 g) neither in the efficacy rates nor in their safety. From these results, LAPC as well as BAPC are considered to be highly useful antibacterial agents for the treatment of respiratory tract infections.</abstract><cop>Japan</cop><pub>The Japanese Association for Infectious Diseases</pub><pmid>3932547</pmid><doi>10.11150/kansenshogakuzasshi1970.59.605</doi><tpages>34</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0387-5911 |
| ispartof | Kansenshogaku Zasshi, 1985/06/20, Vol.59(6), pp.605-638 |
| issn | 0387-5911 1884-569X |
| language | eng ; jpn |
| recordid | cdi_crossref_primary_10_11150_kansenshogakuzasshi1970_59_605 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Ampicillin - administration & dosage Ampicillin - adverse effects Ampicillin - analogs & derivatives Ampicillin - therapeutic use Bacampicillin Clinical Trials as Topic Combarative Study Double-Blind Method Female Humans KBT-1585 LAPC Lenampicillin Male Middle Aged Pneumonia Pneumonia - drug therapy Pneumonia - microbiology |
| title | Comparative Study of the Effectiveness of Lenampicillin and Bacampicillin on Bacterial Pneumonia by Double Blind Method |
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