Acute effects of oestrogen on the guinea pig and human I Kr channels and drug‐induced prolongation of cardiac repolarization

Female gender is a risk factor for drug‐induced arrhythmias associated with QT prolongation, which results mostly from blockade of the human ether‐a‐go‐go‐related gene (hERG) channel. Some clinical evidence suggests that oestrogen is a determinant of the gender‐differences in drug‐induced QT prolong...

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Veröffentlicht in:	The Journal of physiology 2008-06, Vol.586 (12), p.2961-2973
Hauptverfasser:	Kurokawa, Junko, Tamagawa, Masaji, Harada, Nobuhiro, Honda, Shin‐ichiro, Bai, Chang‐Xi, Nakaya, Haruaki, Furukawa, Tetsushi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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