Frequency‐dependent myofilament Ca 2+ desensitization in failing rat myocardium

The positive force–frequency relation, one of the key factors modulating performance of healthy myocardium, has been attributed to an increased Ca 2 + influx per unit of time. In failing hearts, a blunted, flat or negative force–frequency relation has been found. In healthy and failing hearts freque...

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Veröffentlicht in:	The Journal of physiology 2007-07, Vol.582 (2), p.695-709
Hauptverfasser:	Lamberts, Regis R., Hamdani, Nazha, Soekhoe, Tenoedj W., Boontje, Nicky M., Zaremba, Ruud, Walker, Lori A., De Tombe, Pieter P., Van Der Velden, Jolanda, Stienen, Ger J. M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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