Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure

Key points Heart failure patients with reduced ejection fraction (HFrEF) exhibit severe limitations in exercise capacity (V̇O2 peak). One of the primary peripheral mechanisms suggested to underlie exercise intolerance in HFrEF is excessive locomotor muscle group III/IV afferent feedback; however, th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of physiology 2020-12, Vol.598 (23), p.5379-5390
Hauptverfasser:	Smith, Joshua R., Joyner, Michael J., Curry, Timothy B., Borlaug, Barry A., Keller‐Ross, Manda L., Van Iterson, Erik H., Olson, Thomas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylene Blood flow Congestive heart failure Exercise exercise limitation exercise pressor reflex Fentanyl Gases Heart failure Heart Failure - drug therapy Humans Intolerance Leg Life Sciences & Biomedicine Morbidity Motor ability Muscle, Skeletal Neurosciences Neurosciences & Neurology Oxygen Consumption Physiology Science & Technology Sensory neurons Stroke Stroke Volume sympathetic nervous system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!