Electroretinographic changes after intravenous lipid emulsion therapy in a dog and a foal with ivermectin toxicosis
This case report describes ivermectin‐induced blindness in a dog and a foal with normal ophthalmic fundic examinations and attenuated electroretinography (ERG). Subsequent recovery in ERG was noted following intravenous lipid emulsion (ILE) therapy. A dog and a foal were evaluated for ivermectin‐ind...
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| Veröffentlicht in: | Veterinary ophthalmology 2018-01, Vol.21 (1), p.82-87 |
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| creator | Pollio, Danielle Michau, Tammy M. Weaver, Ellen Kuebelbeck, K. Leann |
| description | This case report describes ivermectin‐induced blindness in a dog and a foal with normal ophthalmic fundic examinations and attenuated electroretinography (ERG). Subsequent recovery in ERG was noted following intravenous lipid emulsion (ILE) therapy. A dog and a foal were evaluated for ivermectin‐induced blindness. Clinical signs included dull mentation, absent pupillary light reflexes (PLRs), and absent menace on presentation. The animals had normal fundoscopic examinations; however, in both cases ERG was consistent with neurosensory retinal dysfunction. Following ILE therapy for ivermectin toxicosis, return of menace, PLRs, and normal mentation were noted, as was improvement in ERG and serum ivermectin levels. These are the first documented cases of ivermectin‐induced blindness in a dog and a foal with normal fundic examinations and attenuated ERG. ERG improved in both animals after ILE therapy. ERG may assist in the diagnosis of ivermectin toxicosis in dogs and horses. ILE therapy may hasten recovery in treatment of ivermectin‐induced blindness. |
| doi_str_mv | 10.1111/vop.12410 |
| format | Article |
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Leann</creator><creatorcontrib>Pollio, Danielle ; Michau, Tammy M. ; Weaver, Ellen ; Kuebelbeck, K. Leann</creatorcontrib><description>This case report describes ivermectin‐induced blindness in a dog and a foal with normal ophthalmic fundic examinations and attenuated electroretinography (ERG). Subsequent recovery in ERG was noted following intravenous lipid emulsion (ILE) therapy. A dog and a foal were evaluated for ivermectin‐induced blindness. Clinical signs included dull mentation, absent pupillary light reflexes (PLRs), and absent menace on presentation. The animals had normal fundoscopic examinations; however, in both cases ERG was consistent with neurosensory retinal dysfunction. Following ILE therapy for ivermectin toxicosis, return of menace, PLRs, and normal mentation were noted, as was improvement in ERG and serum ivermectin levels. These are the first documented cases of ivermectin‐induced blindness in a dog and a foal with normal fundic examinations and attenuated ERG. ERG improved in both animals after ILE therapy. ERG may assist in the diagnosis of ivermectin toxicosis in dogs and horses. ILE therapy may hasten recovery in treatment of ivermectin‐induced blindness.</description><identifier>ISSN: 1463-5216</identifier><identifier>EISSN: 1463-5224</identifier><identifier>DOI: 10.1111/vop.12410</identifier><identifier>PMID: 27440451</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Animals, Newborn ; Antiparasitic Agents - toxicity ; Blindness - chemically induced ; Blindness - diagnosis ; Blindness - veterinary ; canine ; Dog Diseases - chemically induced ; Dog Diseases - diagnosis ; Dog Diseases - drug therapy ; Dogs ; electroretinogram ; Electroretinography - veterinary ; equine ; Fat Emulsions, Intravenous - administration & dosage ; Fat Emulsions, Intravenous - therapeutic use ; Female ; Horse Diseases - chemically induced ; Horse Diseases - diagnosis ; Horse Diseases - drug therapy ; Horses ; ivermectin ; Ivermectin - toxicity ; lipid ; toxicity</subject><ispartof>Veterinary ophthalmology, 2018-01, Vol.21 (1), p.82-87</ispartof><rights>2016 American College of Veterinary Ophthalmologists</rights><rights>2016 American College of Veterinary Ophthalmologists.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3270-f42f5810e81fb374fc385b4cb141927e6fb5aa2b92b3eb08da10f5ea7e3e88963</citedby><cites>FETCH-LOGICAL-c3270-f42f5810e81fb374fc385b4cb141927e6fb5aa2b92b3eb08da10f5ea7e3e88963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvop.12410$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvop.12410$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27440451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pollio, Danielle</creatorcontrib><creatorcontrib>Michau, Tammy M.</creatorcontrib><creatorcontrib>Weaver, Ellen</creatorcontrib><creatorcontrib>Kuebelbeck, K. Leann</creatorcontrib><title>Electroretinographic changes after intravenous lipid emulsion therapy in a dog and a foal with ivermectin toxicosis</title><title>Veterinary ophthalmology</title><addtitle>Vet Ophthalmol</addtitle><description>This case report describes ivermectin‐induced blindness in a dog and a foal with normal ophthalmic fundic examinations and attenuated electroretinography (ERG). Subsequent recovery in ERG was noted following intravenous lipid emulsion (ILE) therapy. A dog and a foal were evaluated for ivermectin‐induced blindness. Clinical signs included dull mentation, absent pupillary light reflexes (PLRs), and absent menace on presentation. The animals had normal fundoscopic examinations; however, in both cases ERG was consistent with neurosensory retinal dysfunction. Following ILE therapy for ivermectin toxicosis, return of menace, PLRs, and normal mentation were noted, as was improvement in ERG and serum ivermectin levels. These are the first documented cases of ivermectin‐induced blindness in a dog and a foal with normal fundic examinations and attenuated ERG. ERG improved in both animals after ILE therapy. ERG may assist in the diagnosis of ivermectin toxicosis in dogs and horses. ILE therapy may hasten recovery in treatment of ivermectin‐induced blindness.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antiparasitic Agents - toxicity</subject><subject>Blindness - chemically induced</subject><subject>Blindness - diagnosis</subject><subject>Blindness - veterinary</subject><subject>canine</subject><subject>Dog Diseases - chemically induced</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - drug therapy</subject><subject>Dogs</subject><subject>electroretinogram</subject><subject>Electroretinography - veterinary</subject><subject>equine</subject><subject>Fat Emulsions, Intravenous - administration & dosage</subject><subject>Fat Emulsions, Intravenous - therapeutic use</subject><subject>Female</subject><subject>Horse Diseases - chemically induced</subject><subject>Horse Diseases - diagnosis</subject><subject>Horse Diseases - drug therapy</subject><subject>Horses</subject><subject>ivermectin</subject><subject>Ivermectin - toxicity</subject><subject>lipid</subject><subject>toxicity</subject><issn>1463-5216</issn><issn>1463-5224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0EoqWw4AeQtyzS-pVHl6gqDwmpLIBtZDvjxiiNIztt6d9jCHTHbOYuztyRDkLXlExpnNnOdVPKBCUnaExFxpOUMXF6zDQboYsQPgghPCX5ORqxXAgiUjpGYdmA7r3z0NvWrb3saquxrmW7hoCl6cFj2_Ze7qB124Ab29kKw2bbBOta3NcQTw4RwRJXbo1lW8VknGzw3vY1tjvwm_ghAr37tNoFGy7RmZFNgKvfPUFv98vXxWPyvHp4Wtw9J5qznCRGMJMWlEBBjeK5MJoXqRJaUUHnLIfMqFRKpuZMcVCkqCQlJgWZA4eimGd8gm6HXu1dCB5M2Xm7kf5QUlJ-iyujuPJHXGRvBrbbqg1UR_LPVARmA7C3DRz-byrfVy9D5Rdi2np7</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Pollio, Danielle</creator><creator>Michau, Tammy M.</creator><creator>Weaver, Ellen</creator><creator>Kuebelbeck, K. Leann</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201801</creationdate><title>Electroretinographic changes after intravenous lipid emulsion therapy in a dog and a foal with ivermectin toxicosis</title><author>Pollio, Danielle ; Michau, Tammy M. ; Weaver, Ellen ; Kuebelbeck, K. Leann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3270-f42f5810e81fb374fc385b4cb141927e6fb5aa2b92b3eb08da10f5ea7e3e88963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antiparasitic Agents - toxicity</topic><topic>Blindness - chemically induced</topic><topic>Blindness - diagnosis</topic><topic>Blindness - veterinary</topic><topic>canine</topic><topic>Dog Diseases - chemically induced</topic><topic>Dog Diseases - diagnosis</topic><topic>Dog Diseases - drug therapy</topic><topic>Dogs</topic><topic>electroretinogram</topic><topic>Electroretinography - veterinary</topic><topic>equine</topic><topic>Fat Emulsions, Intravenous - administration & dosage</topic><topic>Fat Emulsions, Intravenous - therapeutic use</topic><topic>Female</topic><topic>Horse Diseases - chemically induced</topic><topic>Horse Diseases - diagnosis</topic><topic>Horse Diseases - drug therapy</topic><topic>Horses</topic><topic>ivermectin</topic><topic>Ivermectin - toxicity</topic><topic>lipid</topic><topic>toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pollio, Danielle</creatorcontrib><creatorcontrib>Michau, Tammy M.</creatorcontrib><creatorcontrib>Weaver, Ellen</creatorcontrib><creatorcontrib>Kuebelbeck, K. Leann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Veterinary ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pollio, Danielle</au><au>Michau, Tammy M.</au><au>Weaver, Ellen</au><au>Kuebelbeck, K. Leann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electroretinographic changes after intravenous lipid emulsion therapy in a dog and a foal with ivermectin toxicosis</atitle><jtitle>Veterinary ophthalmology</jtitle><addtitle>Vet Ophthalmol</addtitle><date>2018-01</date><risdate>2018</risdate><volume>21</volume><issue>1</issue><spage>82</spage><epage>87</epage><pages>82-87</pages><issn>1463-5216</issn><eissn>1463-5224</eissn><abstract>This case report describes ivermectin‐induced blindness in a dog and a foal with normal ophthalmic fundic examinations and attenuated electroretinography (ERG). Subsequent recovery in ERG was noted following intravenous lipid emulsion (ILE) therapy. A dog and a foal were evaluated for ivermectin‐induced blindness. Clinical signs included dull mentation, absent pupillary light reflexes (PLRs), and absent menace on presentation. The animals had normal fundoscopic examinations; however, in both cases ERG was consistent with neurosensory retinal dysfunction. Following ILE therapy for ivermectin toxicosis, return of menace, PLRs, and normal mentation were noted, as was improvement in ERG and serum ivermectin levels. These are the first documented cases of ivermectin‐induced blindness in a dog and a foal with normal fundic examinations and attenuated ERG. ERG improved in both animals after ILE therapy. ERG may assist in the diagnosis of ivermectin toxicosis in dogs and horses. ILE therapy may hasten recovery in treatment of ivermectin‐induced blindness.</abstract><cop>England</cop><pmid>27440451</pmid><doi>10.1111/vop.12410</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Animals, Newborn Antiparasitic Agents - toxicity Blindness - chemically induced Blindness - diagnosis Blindness - veterinary canine Dog Diseases - chemically induced Dog Diseases - diagnosis Dog Diseases - drug therapy Dogs electroretinogram Electroretinography - veterinary equine Fat Emulsions, Intravenous - administration & dosage Fat Emulsions, Intravenous - therapeutic use Female Horse Diseases - chemically induced Horse Diseases - diagnosis Horse Diseases - drug therapy Horses ivermectin Ivermectin - toxicity lipid toxicity |
| title | Electroretinographic changes after intravenous lipid emulsion therapy in a dog and a foal with ivermectin toxicosis |
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