Treatment of advanced canine anal sac adenocarcinoma with hypofractionated radiation therapy: 77 cases (1999–2013)
Currently no standard of care exists for advanced, inoperable or metastatic anal sac adenocarcinoma (ASAC). The objective of this retrospective study was to assess the role of hypofractionated radiation therapy (RT) in 77 dogs with measurable ASAC. A total of 38% of dogs experienced a partial respon...
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| Veröffentlicht in: | Veterinary & comparative oncology 2017-09, Vol.15 (3), p.840-851 |
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| container_title | Veterinary & comparative oncology |
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| creator | McQuown, B. Keyerleber, M. A. Rosen, K. McEntee, M. C. Burgess, K. E. |
| description | Currently no standard of care exists for advanced, inoperable or metastatic anal sac adenocarcinoma (ASAC). The objective of this retrospective study was to assess the role of hypofractionated radiation therapy (RT) in 77 dogs with measurable ASAC. A total of 38% of dogs experienced a partial response to RT. For dogs presenting with clinical signs related to the tumour, improvement or resolution of signs was noted in 63%. For dogs presenting with hypercalcemia of malignancy, resolution was noted in 31% with RT alone and an additional 46% with radiation, prednisone, and/or bisphosphonates. Median overall survival was 329 days (range: 252–448 days). Median progression free survival was 289 days (range: 224–469). There was no difference in survival based on radiation protocol, use of chemotherapy, previous surgery or advanced stage. Radiation toxicities were mild and infrequent. Hypofractionated RT is well tolerated and is applicable in the treatment of advanced primary, locoregional or metastatic ASAC. |
| doi_str_mv | 10.1111/vco.12226 |
| format | Article |
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A. ; Rosen, K. ; McEntee, M. C. ; Burgess, K. E.</creator><creatorcontrib>McQuown, B. ; Keyerleber, M. A. ; Rosen, K. ; McEntee, M. C. ; Burgess, K. E.</creatorcontrib><description>Currently no standard of care exists for advanced, inoperable or metastatic anal sac adenocarcinoma (ASAC). The objective of this retrospective study was to assess the role of hypofractionated radiation therapy (RT) in 77 dogs with measurable ASAC. A total of 38% of dogs experienced a partial response to RT. For dogs presenting with clinical signs related to the tumour, improvement or resolution of signs was noted in 63%. For dogs presenting with hypercalcemia of malignancy, resolution was noted in 31% with RT alone and an additional 46% with radiation, prednisone, and/or bisphosphonates. Median overall survival was 329 days (range: 252–448 days). Median progression free survival was 289 days (range: 224–469). There was no difference in survival based on radiation protocol, use of chemotherapy, previous surgery or advanced stage. Radiation toxicities were mild and infrequent. Hypofractionated RT is well tolerated and is applicable in the treatment of advanced primary, locoregional or metastatic ASAC.</description><identifier>ISSN: 1476-5810</identifier><identifier>EISSN: 1476-5829</identifier><identifier>DOI: 10.1111/vco.12226</identifier><identifier>PMID: 26991552</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - radiotherapy ; Adenocarcinoma - veterinary ; Anal Gland Neoplasms - mortality ; Anal Gland Neoplasms - radiotherapy ; anal sac adenocarcinoma ; Anal Sacs ; Animals ; Dog Diseases - mortality ; Dog Diseases - radiotherapy ; Dogs ; Dose Hypofractionation ; Female ; hypofractionated ; Male ; oncology ; palliative ; radiation oncology ; radiation therapy ; Retrospective Studies ; small animal</subject><ispartof>Veterinary & comparative oncology, 2017-09, Vol.15 (3), p.840-851</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3256-ac05ae681a8f72cdd9e772e98e528c137d12e3e1067eff79c14b408f5638be823</citedby><cites>FETCH-LOGICAL-c3256-ac05ae681a8f72cdd9e772e98e528c137d12e3e1067eff79c14b408f5638be823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvco.12226$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvco.12226$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26991552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McQuown, B.</creatorcontrib><creatorcontrib>Keyerleber, M. A.</creatorcontrib><creatorcontrib>Rosen, K.</creatorcontrib><creatorcontrib>McEntee, M. C.</creatorcontrib><creatorcontrib>Burgess, K. E.</creatorcontrib><title>Treatment of advanced canine anal sac adenocarcinoma with hypofractionated radiation therapy: 77 cases (1999–2013)</title><title>Veterinary & comparative oncology</title><addtitle>Vet Comp Oncol</addtitle><description>Currently no standard of care exists for advanced, inoperable or metastatic anal sac adenocarcinoma (ASAC). The objective of this retrospective study was to assess the role of hypofractionated radiation therapy (RT) in 77 dogs with measurable ASAC. A total of 38% of dogs experienced a partial response to RT. For dogs presenting with clinical signs related to the tumour, improvement or resolution of signs was noted in 63%. For dogs presenting with hypercalcemia of malignancy, resolution was noted in 31% with RT alone and an additional 46% with radiation, prednisone, and/or bisphosphonates. Median overall survival was 329 days (range: 252–448 days). Median progression free survival was 289 days (range: 224–469). There was no difference in survival based on radiation protocol, use of chemotherapy, previous surgery or advanced stage. Radiation toxicities were mild and infrequent. Hypofractionated RT is well tolerated and is applicable in the treatment of advanced primary, locoregional or metastatic ASAC.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - radiotherapy</subject><subject>Adenocarcinoma - veterinary</subject><subject>Anal Gland Neoplasms - mortality</subject><subject>Anal Gland Neoplasms - radiotherapy</subject><subject>anal sac adenocarcinoma</subject><subject>Anal Sacs</subject><subject>Animals</subject><subject>Dog Diseases - mortality</subject><subject>Dog Diseases - radiotherapy</subject><subject>Dogs</subject><subject>Dose Hypofractionation</subject><subject>Female</subject><subject>hypofractionated</subject><subject>Male</subject><subject>oncology</subject><subject>palliative</subject><subject>radiation oncology</subject><subject>radiation therapy</subject><subject>Retrospective Studies</subject><subject>small animal</subject><issn>1476-5810</issn><issn>1476-5829</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1OwzAQxy0EoqUw8ALIIx3S2s6HbTZU8SVV6lJYo6tzVoMap7JDq2y8A2_Ik5ASYOOWu9P97j_8CLnkbMK7mu5MPeFCiOyIDHkisyhVQh__zZwNyFkIr4wJkcTilAxEpjVPUzEkzdIjNBW6htaWQrEDZ7CgBlzpkIKDDQ1gugO62oA3pasroPuyWdN1u62tB9OUtYOme_JQlHDYaLNGD9v2hkrZRQUM9JprrT_fPwTj8ficnFjYBLz46SPyfH-3nD1G88XD0-x2HplYpFkEhqWAmeKgrBSmKDRKKVArTIUyPJYFFxgjZ5lEa6U2PFklTNk0i9UKlYhHZNznGl-H4NHmW19W4Nucs_xgLu_M5d_mOvaqZ7dvqwqLP_JXVQdMe2BfbrD9Pyl_mS36yC_cV3ia</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>McQuown, B.</creator><creator>Keyerleber, M. A.</creator><creator>Rosen, K.</creator><creator>McEntee, M. C.</creator><creator>Burgess, K. E.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201709</creationdate><title>Treatment of advanced canine anal sac adenocarcinoma with hypofractionated radiation therapy: 77 cases (1999–2013)</title><author>McQuown, B. ; Keyerleber, M. A. ; Rosen, K. ; McEntee, M. C. ; Burgess, K. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3256-ac05ae681a8f72cdd9e772e98e528c137d12e3e1067eff79c14b408f5638be823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - radiotherapy</topic><topic>Adenocarcinoma - veterinary</topic><topic>Anal Gland Neoplasms - mortality</topic><topic>Anal Gland Neoplasms - radiotherapy</topic><topic>anal sac adenocarcinoma</topic><topic>Anal Sacs</topic><topic>Animals</topic><topic>Dog Diseases - mortality</topic><topic>Dog Diseases - radiotherapy</topic><topic>Dogs</topic><topic>Dose Hypofractionation</topic><topic>Female</topic><topic>hypofractionated</topic><topic>Male</topic><topic>oncology</topic><topic>palliative</topic><topic>radiation oncology</topic><topic>radiation therapy</topic><topic>Retrospective Studies</topic><topic>small animal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McQuown, B.</creatorcontrib><creatorcontrib>Keyerleber, M. A.</creatorcontrib><creatorcontrib>Rosen, K.</creatorcontrib><creatorcontrib>McEntee, M. C.</creatorcontrib><creatorcontrib>Burgess, K. E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Veterinary & comparative oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McQuown, B.</au><au>Keyerleber, M. A.</au><au>Rosen, K.</au><au>McEntee, M. C.</au><au>Burgess, K. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of advanced canine anal sac adenocarcinoma with hypofractionated radiation therapy: 77 cases (1999–2013)</atitle><jtitle>Veterinary & comparative oncology</jtitle><addtitle>Vet Comp Oncol</addtitle><date>2017-09</date><risdate>2017</risdate><volume>15</volume><issue>3</issue><spage>840</spage><epage>851</epage><pages>840-851</pages><issn>1476-5810</issn><eissn>1476-5829</eissn><abstract>Currently no standard of care exists for advanced, inoperable or metastatic anal sac adenocarcinoma (ASAC). The objective of this retrospective study was to assess the role of hypofractionated radiation therapy (RT) in 77 dogs with measurable ASAC. A total of 38% of dogs experienced a partial response to RT. For dogs presenting with clinical signs related to the tumour, improvement or resolution of signs was noted in 63%. For dogs presenting with hypercalcemia of malignancy, resolution was noted in 31% with RT alone and an additional 46% with radiation, prednisone, and/or bisphosphonates. Median overall survival was 329 days (range: 252–448 days). Median progression free survival was 289 days (range: 224–469). There was no difference in survival based on radiation protocol, use of chemotherapy, previous surgery or advanced stage. Radiation toxicities were mild and infrequent. Hypofractionated RT is well tolerated and is applicable in the treatment of advanced primary, locoregional or metastatic ASAC.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>26991552</pmid><doi>10.1111/vco.12226</doi><tpages>12</tpages></addata></record> |
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| ispartof | Veterinary & comparative oncology, 2017-09, Vol.15 (3), p.840-851 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adenocarcinoma - mortality Adenocarcinoma - radiotherapy Adenocarcinoma - veterinary Anal Gland Neoplasms - mortality Anal Gland Neoplasms - radiotherapy anal sac adenocarcinoma Anal Sacs Animals Dog Diseases - mortality Dog Diseases - radiotherapy Dogs Dose Hypofractionation Female hypofractionated Male oncology palliative radiation oncology radiation therapy Retrospective Studies small animal |
| title | Treatment of advanced canine anal sac adenocarcinoma with hypofractionated radiation therapy: 77 cases (1999–2013) |
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