Anti-N and anti-Do a immunoglobulin G alloantibody-mediated delayed hemolytic transfusion reaction with hyperhemolysis in sickle cell disease treated with eculizumab and HBOC-201: case report and review of the literature

Delayed hemolytic transfusion reaction (DHTR) with hyperhemolysis is a potentially fatal complication resulting from alloimmunization that can cause severe hemolysis of both transfused and intrinsic red blood cells (RBCs). Patients with sickle cell disease often receive multiple RBC units during the...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2019-06, Vol.59 (6), p.1907-1910
Hauptverfasser:	Unnikrishnan, Athira, Pelletier, J Peter R, Bari, Shahla, Zumberg, Marc, Shahmohamadi, Abbas, Spiess, Bruce D, Michael, Mary Jane, Harris, Neil, Harrell, Danielle, Mandernach, Molly W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anemia, Hemolytic, Autoimmune - blood Anemia, Hemolytic, Autoimmune - etiology Anemia, Hemolytic, Autoimmune - immunology Anemia, Sickle Cell - blood Anemia, Sickle Cell - immunology Anemia, Sickle Cell - therapy Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - immunology Female Hemoglobins - administration & dosage Hemoglobins - adverse effects Hemoglobins - immunology Hemolysis - immunology Humans Immunoglobulin G - blood Immunoglobulin G - physiology Isoantibodies - blood Isoantibodies - physiology Time Factors Transfusion Reaction - blood Transfusion Reaction - etiology Transfusion Reaction - immunology
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