HLA allele and haplotype frequencies in Kazakhstani Russians and their relationship with other populations

HLA class I and class II genotypes from 947 Kazakhstani individuals of Russian origin were analyzed for investigating their most likely origin. The results were compared with similar data from other Russians (East and West), and also Worldwide populations, using standard genetic distances, neighbor‐...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:HLA 2023-03, Vol.101 (3), p.249-261
Hauptverfasser: Hajjej, Abdelhafidh, Abdrakhmanova, Saniya, Turganbekova, Aida, Almawi, Wassim Y.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 261
container_issue 3
container_start_page 249
container_title HLA
container_volume 101
creator Hajjej, Abdelhafidh
Abdrakhmanova, Saniya
Turganbekova, Aida
Almawi, Wassim Y.
description HLA class I and class II genotypes from 947 Kazakhstani individuals of Russian origin were analyzed for investigating their most likely origin. The results were compared with similar data from other Russians (East and West), and also Worldwide populations, using standard genetic distances, neighbor‐joining dendrograms, correspondence and haplotype analysis. Of the five HLA loci analyzed (HLA‐A, HLA‐C, HLA‐B, HLA‐DRB1, and HLA‐DQB1) genotyped, 216 HLA alleles were identified. The most frequent alleles were A*02:01 (26.5%), B*07:02 (11.1%), C*04:01 (13.5%) and C*06:02 (12.1%), DRB1*07:01 (13.8%) and DRB1*15:01 (12.2%), and DQB1*03:01 (19.7%). Significant linkage disequilibrium was noted between all HLA pairs. DRB1*15:01 ~ DQB1*06:02 (10.5%), B*07:02 ~ C*07:02 (10.0%), B*07:02 ~ DRB1*15:01 (6.3%), and A*01:01 ~ B*08:01 (4.5%) were the most frequent two‐locus haplotypes identified. Subsequent analyses showed that Kazakhstani Russians were closely related to West Russia‐residing populations (Northwest Slavic, Vologda, Chelyabinsk, Moscow), East Europeans (Belarus Brest, Ukraine, Poland) and Scandinavians (Swedish, Finns), but distinct from East Russia‐residing populations (Tuvians, Siberians from Chukotka, Kamchatka, and Ulchi) and East Mediterraneans (Levantines, Turks, North Macedonians, Albanians), and East Asians (Koreans, Japanese, Taiwanese, Mongolians). These results are in accordance with historical data indicating that the Russians of central Asia originate mainly from European Russia during the migratory flow of 18th and 19th centuries.
doi_str_mv 10.1111/tan.14937
format Article
fullrecord <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1111_tan_14937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>TAN14937</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2887-43169c7444b5f7fcd80faad731c748f09bd75bb52e7fde2f870a1f85f457758d3</originalsourceid><addsrcrecordid>eNp1kMFOwzAMhiMEYtPYgRdAuXLolqRN0xynCTbEBBIa5yptEzWQtSFpNY2nJ6xjN3yxZX_-Lf8A3GI0wyHmnWhmOOExuwBjgiiPSIzR5blGZASm3usCkZQzlDJ-DUZxShEhjI_Bx3qzgMIYaSQUTQVrYU3bHayEysmvXjallh7qBj6Lb_FZ-3BNw7c-CIrGHze6WmoHnTSi023ja23hXnc1bMPAQdva_jS5AVdKGC-npzwB748P2-U62ryunpaLTVSSLGNREuOUlyxJkoIqpsoqQ0qIisU4NDOFeFExWhSUSKYqSVTGkMAqoyqhjNGsiifgftAtXeu9kyq3Tu-EO-QY5b-W5eGJ_GhZYO8G1vbFTlZn8s-gAMwHYK-NPPyvlG8XL4PkDyxfd7c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>HLA allele and haplotype frequencies in Kazakhstani Russians and their relationship with other populations</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Hajjej, Abdelhafidh ; Abdrakhmanova, Saniya ; Turganbekova, Aida ; Almawi, Wassim Y.</creator><creatorcontrib>Hajjej, Abdelhafidh ; Abdrakhmanova, Saniya ; Turganbekova, Aida ; Almawi, Wassim Y.</creatorcontrib><description>HLA class I and class II genotypes from 947 Kazakhstani individuals of Russian origin were analyzed for investigating their most likely origin. The results were compared with similar data from other Russians (East and West), and also Worldwide populations, using standard genetic distances, neighbor‐joining dendrograms, correspondence and haplotype analysis. Of the five HLA loci analyzed (HLA‐A, HLA‐C, HLA‐B, HLA‐DRB1, and HLA‐DQB1) genotyped, 216 HLA alleles were identified. The most frequent alleles were A*02:01 (26.5%), B*07:02 (11.1%), C*04:01 (13.5%) and C*06:02 (12.1%), DRB1*07:01 (13.8%) and DRB1*15:01 (12.2%), and DQB1*03:01 (19.7%). Significant linkage disequilibrium was noted between all HLA pairs. DRB1*15:01 ~ DQB1*06:02 (10.5%), B*07:02 ~ C*07:02 (10.0%), B*07:02 ~ DRB1*15:01 (6.3%), and A*01:01 ~ B*08:01 (4.5%) were the most frequent two‐locus haplotypes identified. Subsequent analyses showed that Kazakhstani Russians were closely related to West Russia‐residing populations (Northwest Slavic, Vologda, Chelyabinsk, Moscow), East Europeans (Belarus Brest, Ukraine, Poland) and Scandinavians (Swedish, Finns), but distinct from East Russia‐residing populations (Tuvians, Siberians from Chukotka, Kamchatka, and Ulchi) and East Mediterraneans (Levantines, Turks, North Macedonians, Albanians), and East Asians (Koreans, Japanese, Taiwanese, Mongolians). These results are in accordance with historical data indicating that the Russians of central Asia originate mainly from European Russia during the migratory flow of 18th and 19th centuries.</description><identifier>ISSN: 2059-2302</identifier><identifier>EISSN: 2059-2310</identifier><identifier>DOI: 10.1111/tan.14937</identifier><identifier>PMID: 36502279</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Alleles ; Gene Frequency ; Genes, MHC Class I ; genotypes ; Haplotypes ; HLA ; HLA-DQ beta-Chains - genetics ; HLA-DRB1 Chains - genetics ; Humans ; Kazakhstan ; Population Groups ; Russia</subject><ispartof>HLA, 2023-03, Vol.101 (3), p.249-261</ispartof><rights>2022 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2887-43169c7444b5f7fcd80faad731c748f09bd75bb52e7fde2f870a1f85f457758d3</citedby><cites>FETCH-LOGICAL-c2887-43169c7444b5f7fcd80faad731c748f09bd75bb52e7fde2f870a1f85f457758d3</cites><orcidid>0000-0003-1633-9757</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftan.14937$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftan.14937$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36502279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hajjej, Abdelhafidh</creatorcontrib><creatorcontrib>Abdrakhmanova, Saniya</creatorcontrib><creatorcontrib>Turganbekova, Aida</creatorcontrib><creatorcontrib>Almawi, Wassim Y.</creatorcontrib><title>HLA allele and haplotype frequencies in Kazakhstani Russians and their relationship with other populations</title><title>HLA</title><addtitle>HLA</addtitle><description>HLA class I and class II genotypes from 947 Kazakhstani individuals of Russian origin were analyzed for investigating their most likely origin. The results were compared with similar data from other Russians (East and West), and also Worldwide populations, using standard genetic distances, neighbor‐joining dendrograms, correspondence and haplotype analysis. Of the five HLA loci analyzed (HLA‐A, HLA‐C, HLA‐B, HLA‐DRB1, and HLA‐DQB1) genotyped, 216 HLA alleles were identified. The most frequent alleles were A*02:01 (26.5%), B*07:02 (11.1%), C*04:01 (13.5%) and C*06:02 (12.1%), DRB1*07:01 (13.8%) and DRB1*15:01 (12.2%), and DQB1*03:01 (19.7%). Significant linkage disequilibrium was noted between all HLA pairs. DRB1*15:01 ~ DQB1*06:02 (10.5%), B*07:02 ~ C*07:02 (10.0%), B*07:02 ~ DRB1*15:01 (6.3%), and A*01:01 ~ B*08:01 (4.5%) were the most frequent two‐locus haplotypes identified. Subsequent analyses showed that Kazakhstani Russians were closely related to West Russia‐residing populations (Northwest Slavic, Vologda, Chelyabinsk, Moscow), East Europeans (Belarus Brest, Ukraine, Poland) and Scandinavians (Swedish, Finns), but distinct from East Russia‐residing populations (Tuvians, Siberians from Chukotka, Kamchatka, and Ulchi) and East Mediterraneans (Levantines, Turks, North Macedonians, Albanians), and East Asians (Koreans, Japanese, Taiwanese, Mongolians). These results are in accordance with historical data indicating that the Russians of central Asia originate mainly from European Russia during the migratory flow of 18th and 19th centuries.</description><subject>Alleles</subject><subject>Gene Frequency</subject><subject>Genes, MHC Class I</subject><subject>genotypes</subject><subject>Haplotypes</subject><subject>HLA</subject><subject>HLA-DQ beta-Chains - genetics</subject><subject>HLA-DRB1 Chains - genetics</subject><subject>Humans</subject><subject>Kazakhstan</subject><subject>Population Groups</subject><subject>Russia</subject><issn>2059-2302</issn><issn>2059-2310</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFOwzAMhiMEYtPYgRdAuXLolqRN0xynCTbEBBIa5yptEzWQtSFpNY2nJ6xjN3yxZX_-Lf8A3GI0wyHmnWhmOOExuwBjgiiPSIzR5blGZASm3usCkZQzlDJ-DUZxShEhjI_Bx3qzgMIYaSQUTQVrYU3bHayEysmvXjallh7qBj6Lb_FZ-3BNw7c-CIrGHze6WmoHnTSi023ja23hXnc1bMPAQdva_jS5AVdKGC-npzwB748P2-U62ryunpaLTVSSLGNREuOUlyxJkoIqpsoqQ0qIisU4NDOFeFExWhSUSKYqSVTGkMAqoyqhjNGsiifgftAtXeu9kyq3Tu-EO-QY5b-W5eGJ_GhZYO8G1vbFTlZn8s-gAMwHYK-NPPyvlG8XL4PkDyxfd7c</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Hajjej, Abdelhafidh</creator><creator>Abdrakhmanova, Saniya</creator><creator>Turganbekova, Aida</creator><creator>Almawi, Wassim Y.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-1633-9757</orcidid></search><sort><creationdate>202303</creationdate><title>HLA allele and haplotype frequencies in Kazakhstani Russians and their relationship with other populations</title><author>Hajjej, Abdelhafidh ; Abdrakhmanova, Saniya ; Turganbekova, Aida ; Almawi, Wassim Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2887-43169c7444b5f7fcd80faad731c748f09bd75bb52e7fde2f870a1f85f457758d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alleles</topic><topic>Gene Frequency</topic><topic>Genes, MHC Class I</topic><topic>genotypes</topic><topic>Haplotypes</topic><topic>HLA</topic><topic>HLA-DQ beta-Chains - genetics</topic><topic>HLA-DRB1 Chains - genetics</topic><topic>Humans</topic><topic>Kazakhstan</topic><topic>Population Groups</topic><topic>Russia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hajjej, Abdelhafidh</creatorcontrib><creatorcontrib>Abdrakhmanova, Saniya</creatorcontrib><creatorcontrib>Turganbekova, Aida</creatorcontrib><creatorcontrib>Almawi, Wassim Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>HLA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hajjej, Abdelhafidh</au><au>Abdrakhmanova, Saniya</au><au>Turganbekova, Aida</au><au>Almawi, Wassim Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA allele and haplotype frequencies in Kazakhstani Russians and their relationship with other populations</atitle><jtitle>HLA</jtitle><addtitle>HLA</addtitle><date>2023-03</date><risdate>2023</risdate><volume>101</volume><issue>3</issue><spage>249</spage><epage>261</epage><pages>249-261</pages><issn>2059-2302</issn><eissn>2059-2310</eissn><abstract>HLA class I and class II genotypes from 947 Kazakhstani individuals of Russian origin were analyzed for investigating their most likely origin. The results were compared with similar data from other Russians (East and West), and also Worldwide populations, using standard genetic distances, neighbor‐joining dendrograms, correspondence and haplotype analysis. Of the five HLA loci analyzed (HLA‐A, HLA‐C, HLA‐B, HLA‐DRB1, and HLA‐DQB1) genotyped, 216 HLA alleles were identified. The most frequent alleles were A*02:01 (26.5%), B*07:02 (11.1%), C*04:01 (13.5%) and C*06:02 (12.1%), DRB1*07:01 (13.8%) and DRB1*15:01 (12.2%), and DQB1*03:01 (19.7%). Significant linkage disequilibrium was noted between all HLA pairs. DRB1*15:01 ~ DQB1*06:02 (10.5%), B*07:02 ~ C*07:02 (10.0%), B*07:02 ~ DRB1*15:01 (6.3%), and A*01:01 ~ B*08:01 (4.5%) were the most frequent two‐locus haplotypes identified. Subsequent analyses showed that Kazakhstani Russians were closely related to West Russia‐residing populations (Northwest Slavic, Vologda, Chelyabinsk, Moscow), East Europeans (Belarus Brest, Ukraine, Poland) and Scandinavians (Swedish, Finns), but distinct from East Russia‐residing populations (Tuvians, Siberians from Chukotka, Kamchatka, and Ulchi) and East Mediterraneans (Levantines, Turks, North Macedonians, Albanians), and East Asians (Koreans, Japanese, Taiwanese, Mongolians). These results are in accordance with historical data indicating that the Russians of central Asia originate mainly from European Russia during the migratory flow of 18th and 19th centuries.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>36502279</pmid><doi>10.1111/tan.14937</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-1633-9757</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 2059-2302
ispartof HLA, 2023-03, Vol.101 (3), p.249-261
issn 2059-2302
2059-2310
language eng
recordid cdi_crossref_primary_10_1111_tan_14937
source MEDLINE; Access via Wiley Online Library
subjects Alleles
Gene Frequency
Genes, MHC Class I
genotypes
Haplotypes
HLA
HLA-DQ beta-Chains - genetics
HLA-DRB1 Chains - genetics
Humans
Kazakhstan
Population Groups
Russia
title HLA allele and haplotype frequencies in Kazakhstani Russians and their relationship with other populations
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A55%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HLA%20allele%20and%20haplotype%20frequencies%20in%20Kazakhstani%20Russians%20and%20their%20relationship%20with%20other%20populations&rft.jtitle=HLA&rft.au=Hajjej,%20Abdelhafidh&rft.date=2023-03&rft.volume=101&rft.issue=3&rft.spage=249&rft.epage=261&rft.pages=249-261&rft.issn=2059-2302&rft.eissn=2059-2310&rft_id=info:doi/10.1111/tan.14937&rft_dat=%3Cwiley_cross%3ETAN14937%3C/wiley_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/36502279&rfr_iscdi=true