Highly sensitised patients awaiting deceased donor renal transplants are disadvantaged by the presence of denatured HLA antibody detected in routine HLA antibody testing

Luminex single antigen bead (SAB) assays used to detect HLA antibodies may artificially increase sensitisation in highly sensitised patients (HSP). The presence of denatured HLA (dHLA) within the assay enables antibodies specific to cryptic HLA epitopes to bind, such antibodies are not clinically re...

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Veröffentlicht in:	HLA 2022-07, Vol.100 (1), p.24-36
Hauptverfasser:	Battle, Richard K., Rennie, Trijntje J. W., Phelan, Paul J., Abel, Angela A., McConnell, Sylvia, Turner, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles denatured HLA Epitopes Graft Rejection - diagnosis highly sensitised patients Histocompatibility Testing - methods HLA antibodies HLA Antigens Humans Isoantibodies Kidney Transplantation
Online-Zugang:	Volltext
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