HIV and host immunogenetics: unraveling the role of HLA-C
Host genetic factors play a major role in determining the outcome of many infections including human immunodeficiency virus (HIV). Multiple host factors have been studied till date showing their varied role in susceptibility or resistance to HIV infection. HLA‐C, however, has been recently started g...
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| Veröffentlicht in: | HLA 2016-11, Vol.88 (5), p.221-231 |
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| container_title | HLA |
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| creator | Bardeskar, N. S. Mania-Pramanik, J. |
| description | Host genetic factors play a major role in determining the outcome of many infections including human immunodeficiency virus (HIV). Multiple host factors have been studied till date showing their varied role in susceptibility or resistance to HIV infection. HLA‐C, however, has been recently started gaining interest in researchers mind revealing its polymorphisms to have an important effect on viral load set‐points, disease progression as well as transmission. In this review report, we have compiled these significant findings of HLA‐C in HIV infection, in an attempt to highlight the need for further research in the area in different ethnic population to establish its role in the infection. |
| doi_str_mv | 10.1111/tan.12882 |
| format | Article |
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S.</creatorcontrib><creatorcontrib>Mania-Pramanik, J.</creatorcontrib><title>HIV and host immunogenetics: unraveling the role of HLA-C</title><title>HLA</title><addtitle>HLA</addtitle><description>Host genetic factors play a major role in determining the outcome of many infections including human immunodeficiency virus (HIV). Multiple host factors have been studied till date showing their varied role in susceptibility or resistance to HIV infection. HLA‐C, however, has been recently started gaining interest in researchers mind revealing its polymorphisms to have an important effect on viral load set‐points, disease progression as well as transmission. In this review report, we have compiled these significant findings of HLA‐C in HIV infection, in an attempt to highlight the need for further research in the area in different ethnic population to establish its role in the infection.</description><subject>35 kb single nucleotide polymorphisms</subject><subject>3′untranslated region</subject><subject>Alleles</subject><subject>Antigens, Viral - genetics</subject><subject>Antigens, Viral - immunology</subject><subject>Cytokines - genetics</subject><subject>Cytokines - immunology</subject><subject>Disease Progression</subject><subject>Disease Resistance - genetics</subject><subject>Disease Susceptibility</subject><subject>Gene Expression</subject><subject>Haplotypes</subject><subject>HIV - genetics</subject><subject>HIV - immunology</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV-1</subject><subject>HLA-C</subject><subject>HLA-C Antigens - genetics</subject><subject>HLA-C Antigens - immunology</subject><subject>Host-Pathogen Interactions</subject><subject>human leukocyte antigen</subject><subject>Humans</subject><subject>Immunity, Innate - genetics</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Lymphocyte Subsets - virology</subject><subject>Polymorphism, Genetic</subject><subject>progression</subject><subject>transmission</subject><subject>Viral Load</subject><issn>2059-2302</issn><issn>2059-2310</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPwkAUhSdGIwRZ-AfMbF0U5tF5uSNEKUpwg7KcTNsZaOyDdArKv7daYefd3Lv4zsm5B4BbjEa4nXFjyhEmUpIL0CeIqYBQjC7PNyI9MPQ-ixHhSiAu1DXoEcEJUoL2gYrm79CUKdxWvoFZUezLamNL22SJf4D7sjYHm2flBjZbC-sqt7ByMFpMgukNuHIm93b4twfg7elxNY2CxetsPp0sgoRySgLpjKScKCxVwkRqBEtCFjoq2uw0TqQIrQtdzEQsHQ4tShyWrI2KGRcpUooOwH3nm9SV97V1eldnhamPGiP904BuG9C_DbTsXcfu9nFh0zN5-rcFxh3wmeX2-L-TXk2WJ8ugU2S-sV9nhak_NBdUML1ezvSahM_8ZR1pTr8BwoFxbQ</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Bardeskar, N. S.</creator><creator>Mania-Pramanik, J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-5310-2479</orcidid></search><sort><creationdate>201611</creationdate><title>HIV and host immunogenetics: unraveling the role of HLA-C</title><author>Bardeskar, N. S. ; Mania-Pramanik, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3632-8fa83629189c57da75c454f371113bc874ef4fb57b8f14e0cf1852691567d0993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>35 kb single nucleotide polymorphisms</topic><topic>3′untranslated region</topic><topic>Alleles</topic><topic>Antigens, Viral - genetics</topic><topic>Antigens, Viral - immunology</topic><topic>Cytokines - genetics</topic><topic>Cytokines - immunology</topic><topic>Disease Progression</topic><topic>Disease Resistance - genetics</topic><topic>Disease Susceptibility</topic><topic>Gene Expression</topic><topic>Haplotypes</topic><topic>HIV - genetics</topic><topic>HIV - immunology</topic><topic>HIV Infections - genetics</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>HIV-1</topic><topic>HLA-C</topic><topic>HLA-C Antigens - genetics</topic><topic>HLA-C Antigens - immunology</topic><topic>Host-Pathogen Interactions</topic><topic>human leukocyte antigen</topic><topic>Humans</topic><topic>Immunity, Innate - genetics</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Lymphocyte Subsets - virology</topic><topic>Polymorphism, Genetic</topic><topic>progression</topic><topic>transmission</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bardeskar, N. S.</creatorcontrib><creatorcontrib>Mania-Pramanik, J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>HLA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bardeskar, N. S.</au><au>Mania-Pramanik, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV and host immunogenetics: unraveling the role of HLA-C</atitle><jtitle>HLA</jtitle><addtitle>HLA</addtitle><date>2016-11</date><risdate>2016</risdate><volume>88</volume><issue>5</issue><spage>221</spage><epage>231</epage><pages>221-231</pages><issn>2059-2302</issn><eissn>2059-2310</eissn><abstract>Host genetic factors play a major role in determining the outcome of many infections including human immunodeficiency virus (HIV). Multiple host factors have been studied till date showing their varied role in susceptibility or resistance to HIV infection. HLA‐C, however, has been recently started gaining interest in researchers mind revealing its polymorphisms to have an important effect on viral load set‐points, disease progression as well as transmission. 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| fulltext | fulltext |
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| ispartof | HLA, 2016-11, Vol.88 (5), p.221-231 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1111_tan_12882 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 35 kb single nucleotide polymorphisms 3′untranslated region Alleles Antigens, Viral - genetics Antigens, Viral - immunology Cytokines - genetics Cytokines - immunology Disease Progression Disease Resistance - genetics Disease Susceptibility Gene Expression Haplotypes HIV - genetics HIV - immunology HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV-1 HLA-C HLA-C Antigens - genetics HLA-C Antigens - immunology Host-Pathogen Interactions human leukocyte antigen Humans Immunity, Innate - genetics Lymphocyte Subsets - immunology Lymphocyte Subsets - virology Polymorphism, Genetic progression transmission Viral Load |
| title | HIV and host immunogenetics: unraveling the role of HLA-C |
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