Somatic mutation in the HLA-B gene of a patient with acute myelogenous leukaemia

In this report we describe a case of somatic mutation in the HLA‐B gene in the tumour cells of a patient with acute myelogenous leukaemia (AML). Routine human leukocyte antigen (HLA) typing of patient by serology and molecular methodologies rendered discrepant results regarding the expression of a B...

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Veröffentlicht in:	HLA 2016-07, Vol.88 (1-2), p.35-37
Hauptverfasser:	Planelles, D., Balas, A., Gil, C., Muñoz, C., Rodríguez-Cebriá, M., Vicario, J. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Codon, Nonsense Exons Female Frameshift Mutation Gene Expression Genotype haematological malignancy Histocompatibility Testing HLA-B HLA-B15 Antigen - genetics HLA-B15 Antigen - immunology Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - pathology Middle Aged Sequence Alignment Sequence Analysis, DNA somatic mutation
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