Dual role of the CXCL12 polymorphism in patients with chronic lymphocytic leukemia

The CXCL12 [chemokine (C–X–C motif) ligand 12] is a member of the CXC family of chemokines and interacts with its CXCR4 receptor. The CXCL12/CXCR4 axis is involved in regulation of proliferation, survival and trafficking of hematopoietic stem cells, including B lymphocytes and disruption within this...

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Veröffentlicht in:	HLA 2016-06, Vol.87 (6), p.432-438
Hauptverfasser:	Butrym, A., Gebura, K., Iwaszko, M., Kuliczkowski, K., Bogunia-Kubik, K., Mazur, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase 1 - genetics ADP-ribosyl Cyclase 1 - immunology Adult Aged Aged, 80 and over Alleles Antigens, Differentiation, B-Lymphocyte - genetics Antigens, Differentiation, B-Lymphocyte - immunology Antineoplastic Combined Chemotherapy Protocols - therapeutic use B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - pathology Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology Case-Control Studies CD74 Chemokine CXCL12 - genetics Chemokine CXCL12 - immunology chronic lymphocytic leukemia CXCL12 Female Gene Expression gene polymorphism Genetic Predisposition to Disease Genotype Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Homozygote Humans Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - pathology Male Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Middle Aged Neoplasm Grading Polymorphism, Single Nucleotide Receptors, CXCR4 - genetics Receptors, CXCR4 - immunology SDF-1 Treatment Outcome
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