Associations between lung and endothelial function in early middle age
ABSTRACT Background and objective Chronic lung disease is associated with impaired endothelial function and this may be a risk factor for poor cardiovascular health. It is unknown if there is an association between lung and endothelial function in the general population. We investigated associations...
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| Veröffentlicht in: | Respirology (Carlton, Vic.) Vic.), 2020-01, Vol.25 (1), p.89-96 |
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| creator | Hancox, Robert J. Thomas, Lathan Williams, Michael J.A. Sears, Malcolm R. |
| description | ABSTRACT
Background and objective
Chronic lung disease is associated with impaired endothelial function and this may be a risk factor for poor cardiovascular health. It is unknown if there is an association between lung and endothelial function in the general population. We investigated associations between lung and endothelial function in a population‐based cohort of 38‐year‐old men and women.
Methods
Systemic endothelial function was measured using peripheral arterial tonometry to calculate the Framingham reactive hyperaemia index. Lung function was assessed using spirometry, plethysmographic lung volumes, airway conductance and gas transfer. Associations between lung and endothelial function were assessed with and without adjustment for potential confounding factors using regression analyses.
Results
Sex modified the association between lung and endothelial function. Among women, lower values of pre‐ and post‐bronchodilator spirometry, total lung capacity and functional residual capacity (FRC) were associated with worse endothelial function (P |
| doi_str_mv | 10.1111/resp.13556 |
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Background and objective
Chronic lung disease is associated with impaired endothelial function and this may be a risk factor for poor cardiovascular health. It is unknown if there is an association between lung and endothelial function in the general population. We investigated associations between lung and endothelial function in a population‐based cohort of 38‐year‐old men and women.
Methods
Systemic endothelial function was measured using peripheral arterial tonometry to calculate the Framingham reactive hyperaemia index. Lung function was assessed using spirometry, plethysmographic lung volumes, airway conductance and gas transfer. Associations between lung and endothelial function were assessed with and without adjustment for potential confounding factors using regression analyses.
Results
Sex modified the association between lung and endothelial function. Among women, lower values of pre‐ and post‐bronchodilator spirometry, total lung capacity and functional residual capacity (FRC) were associated with worse endothelial function (P < 0.05). These associations persisted after adjustment for smoking, asthma diagnoses, fitness and body mass index. Associations were weaker among men: only FRC, airway conductance and post‐bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratios were associated with endothelial function. Endothelial function was not associated with gas transfer in either sex.
Conclusion
Lower lung volumes and airflow obstruction are associated with endothelial dysfunction among women. There is weaker evidence for an association between airway and endothelial function in men. These findings may partly explain the increased risk of cardiovascular disease among people with poor lung function, but suggest that there are sex differences in this association.
Chronic lung disease is associated with endothelial dysfunction, which may lead to cardiovascular disease, but it is unknown when this association develops. In a population‐based cohort of 38‐year olds, we found that low lung volumes and airflow obstruction were associated with endothelial dysfunction in women but associations in men were weaker and less convincing.
See related Editorial</description><identifier>ISSN: 1323-7799</identifier><identifier>EISSN: 1440-1843</identifier><identifier>DOI: 10.1111/resp.13556</identifier><identifier>PMID: 30985946</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>ACE inhibitors ; Asthma ; Body mass index ; Cardiovascular diseases ; Cohort analysis ; cohort studies ; Gender differences ; Hyperemia ; Life Sciences & Biomedicine ; Lung diseases ; obstructive lung diseases ; Respiratory diseases ; Respiratory function ; respiratory function tests ; Respiratory System ; Respiratory tract ; Risk factors ; Science & Technology ; Sex differences ; vascular endothelium ; vasodilation ; Women</subject><ispartof>Respirology (Carlton, Vic.), 2020-01, Vol.25 (1), p.89-96</ispartof><rights>2019 Asian Pacific Society of Respirology</rights><rights>2019 Asian Pacific Society of Respirology.</rights><rights>2020 Asian Pacific Society of Respirology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000572978600022</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3576-91f78efb2e3c4757e676bfc4e439c33bd1dec109d2e2b282ac2ce24f6bff09c33</citedby><cites>FETCH-LOGICAL-c3576-91f78efb2e3c4757e676bfc4e439c33bd1dec109d2e2b282ac2ce24f6bff09c33</cites><orcidid>0000-0002-3922-7144</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fresp.13556$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fresp.13556$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,28253,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30985946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hancox, Robert J.</creatorcontrib><creatorcontrib>Thomas, Lathan</creatorcontrib><creatorcontrib>Williams, Michael J.A.</creatorcontrib><creatorcontrib>Sears, Malcolm R.</creatorcontrib><title>Associations between lung and endothelial function in early middle age</title><title>Respirology (Carlton, Vic.)</title><addtitle>RESPIROLOGY</addtitle><addtitle>Respirology</addtitle><description>ABSTRACT
Background and objective
Chronic lung disease is associated with impaired endothelial function and this may be a risk factor for poor cardiovascular health. It is unknown if there is an association between lung and endothelial function in the general population. We investigated associations between lung and endothelial function in a population‐based cohort of 38‐year‐old men and women.
Methods
Systemic endothelial function was measured using peripheral arterial tonometry to calculate the Framingham reactive hyperaemia index. Lung function was assessed using spirometry, plethysmographic lung volumes, airway conductance and gas transfer. Associations between lung and endothelial function were assessed with and without adjustment for potential confounding factors using regression analyses.
Results
Sex modified the association between lung and endothelial function. Among women, lower values of pre‐ and post‐bronchodilator spirometry, total lung capacity and functional residual capacity (FRC) were associated with worse endothelial function (P < 0.05). These associations persisted after adjustment for smoking, asthma diagnoses, fitness and body mass index. Associations were weaker among men: only FRC, airway conductance and post‐bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratios were associated with endothelial function. Endothelial function was not associated with gas transfer in either sex.
Conclusion
Lower lung volumes and airflow obstruction are associated with endothelial dysfunction among women. There is weaker evidence for an association between airway and endothelial function in men. These findings may partly explain the increased risk of cardiovascular disease among people with poor lung function, but suggest that there are sex differences in this association.
Chronic lung disease is associated with endothelial dysfunction, which may lead to cardiovascular disease, but it is unknown when this association develops. In a population‐based cohort of 38‐year olds, we found that low lung volumes and airflow obstruction were associated with endothelial dysfunction in women but associations in men were weaker and less convincing.
See related Editorial</description><subject>ACE inhibitors</subject><subject>Asthma</subject><subject>Body mass index</subject><subject>Cardiovascular diseases</subject><subject>Cohort analysis</subject><subject>cohort studies</subject><subject>Gender differences</subject><subject>Hyperemia</subject><subject>Life Sciences & Biomedicine</subject><subject>Lung diseases</subject><subject>obstructive lung diseases</subject><subject>Respiratory diseases</subject><subject>Respiratory function</subject><subject>respiratory function tests</subject><subject>Respiratory System</subject><subject>Respiratory tract</subject><subject>Risk factors</subject><subject>Science & Technology</subject><subject>Sex differences</subject><subject>vascular endothelium</subject><subject>vasodilation</subject><subject>Women</subject><issn>1323-7799</issn><issn>1440-1843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqN0U1r3DAQBmBRGvLZS39AEPRSUpzoy5Z9DEu2LQQSkvQsZHm0VdBKG8tm2X9fObvZQw8humgOzwzDOwh9peSS5nfVQ1pdUl6W1Sd0TIUgBa0F_5xrznghZdMcoZOUngkhvCTlITripKnLRlTHaH6dUjRODy6GhFsY1gAB-zEssA4dhtDF4S94pz22YzATwy5g0L3f4KXrOg9YL-AMHVjtE3zZ_afoz_zmafaruL37-Xt2fVsYXsqqaKiVNdiWATdClhIqWbXWCBC8MZy3He3AUNJ0DFjLaqYNM8CEzciSSZyi79u5qz6-jJAGtXTJgPc6QByTYowSQpkQE_32H32OYx_ydopxVtWUi7rK6mKrTB9T6sGqVe-Wut8oStSUrprSVa_pZny-Gzm2S-j29C3ODH5swRraaJNxEAzsWc6_lKyRdZUrxrKuP65nbng90iyOYcitdNfqPGze2Vk93Dzeb7f_Bz_dpWU</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Hancox, Robert J.</creator><creator>Thomas, Lathan</creator><creator>Williams, Michael J.A.</creator><creator>Sears, Malcolm R.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3922-7144</orcidid></search><sort><creationdate>202001</creationdate><title>Associations between lung and endothelial function in early middle age</title><author>Hancox, Robert J. ; Thomas, Lathan ; Williams, Michael J.A. ; Sears, Malcolm R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3576-91f78efb2e3c4757e676bfc4e439c33bd1dec109d2e2b282ac2ce24f6bff09c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>ACE inhibitors</topic><topic>Asthma</topic><topic>Body mass index</topic><topic>Cardiovascular diseases</topic><topic>Cohort analysis</topic><topic>cohort studies</topic><topic>Gender differences</topic><topic>Hyperemia</topic><topic>Life Sciences & Biomedicine</topic><topic>Lung diseases</topic><topic>obstructive lung diseases</topic><topic>Respiratory diseases</topic><topic>Respiratory function</topic><topic>respiratory function tests</topic><topic>Respiratory System</topic><topic>Respiratory tract</topic><topic>Risk factors</topic><topic>Science & Technology</topic><topic>Sex differences</topic><topic>vascular endothelium</topic><topic>vasodilation</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hancox, Robert J.</creatorcontrib><creatorcontrib>Thomas, Lathan</creatorcontrib><creatorcontrib>Williams, Michael J.A.</creatorcontrib><creatorcontrib>Sears, Malcolm R.</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Respirology (Carlton, Vic.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hancox, Robert J.</au><au>Thomas, Lathan</au><au>Williams, Michael J.A.</au><au>Sears, Malcolm R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between lung and endothelial function in early middle age</atitle><jtitle>Respirology (Carlton, Vic.)</jtitle><stitle>RESPIROLOGY</stitle><addtitle>Respirology</addtitle><date>2020-01</date><risdate>2020</risdate><volume>25</volume><issue>1</issue><spage>89</spage><epage>96</epage><pages>89-96</pages><issn>1323-7799</issn><eissn>1440-1843</eissn><abstract>ABSTRACT
Background and objective
Chronic lung disease is associated with impaired endothelial function and this may be a risk factor for poor cardiovascular health. It is unknown if there is an association between lung and endothelial function in the general population. We investigated associations between lung and endothelial function in a population‐based cohort of 38‐year‐old men and women.
Methods
Systemic endothelial function was measured using peripheral arterial tonometry to calculate the Framingham reactive hyperaemia index. Lung function was assessed using spirometry, plethysmographic lung volumes, airway conductance and gas transfer. Associations between lung and endothelial function were assessed with and without adjustment for potential confounding factors using regression analyses.
Results
Sex modified the association between lung and endothelial function. Among women, lower values of pre‐ and post‐bronchodilator spirometry, total lung capacity and functional residual capacity (FRC) were associated with worse endothelial function (P < 0.05). These associations persisted after adjustment for smoking, asthma diagnoses, fitness and body mass index. Associations were weaker among men: only FRC, airway conductance and post‐bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratios were associated with endothelial function. Endothelial function was not associated with gas transfer in either sex.
Conclusion
Lower lung volumes and airflow obstruction are associated with endothelial dysfunction among women. There is weaker evidence for an association between airway and endothelial function in men. These findings may partly explain the increased risk of cardiovascular disease among people with poor lung function, but suggest that there are sex differences in this association.
Chronic lung disease is associated with endothelial dysfunction, which may lead to cardiovascular disease, but it is unknown when this association develops. In a population‐based cohort of 38‐year olds, we found that low lung volumes and airflow obstruction were associated with endothelial dysfunction in women but associations in men were weaker and less convincing.
See related Editorial</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>30985946</pmid><doi>10.1111/resp.13556</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3922-7144</orcidid></addata></record> |
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| subjects | ACE inhibitors Asthma Body mass index Cardiovascular diseases Cohort analysis cohort studies Gender differences Hyperemia Life Sciences & Biomedicine Lung diseases obstructive lung diseases Respiratory diseases Respiratory function respiratory function tests Respiratory System Respiratory tract Risk factors Science & Technology Sex differences vascular endothelium vasodilation Women |
| title | Associations between lung and endothelial function in early middle age |
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