Serum 25(OH)D levels after oral vitamin D 3 supplementation and UVB exposure correlate
The inter-individual variation in 25(OH)D increase (Δ25(OH)D ) after vitamin D supplementation was determined and compared with the UVB irradiation response. Nineteen Danish participants received 85 μg vitamin D (cholecalciferol) daily for nine weeks with regular serum 25(OH)D measurements. These pa...
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| Veröffentlicht in: | Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2019-09, Vol.35 (5), p.344-353 |
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| creator | Datta, Pameli Philipsen, Peter Alshede Olsen, Peter Andersen, Jeppe Dyrberg Morling, Niels Wulf, Hans Christian |
| description | The inter-individual variation in 25(OH)D
increase (Δ25(OH)D
) after vitamin D
supplementation was determined and compared with the UVB irradiation response.
Nineteen Danish participants received 85 μg vitamin D
(cholecalciferol) daily for nine weeks with regular serum 25(OH)D
measurements. These participants had three years earlier taken part in a 9-week controlled UVB study. The Δ25(OH)D
was not confounded by ambient UVB, BMI or ethnicity.
Δ25(OH)D
was 53 nmol L
and almost identical to Δ25(OH)D
(52 nmol L
) after UVB. Δ25(OH)D
ranged from 17 to 91 nmol L
(span 74 nmol L
) and was about half of that observed after UVB irradiation (span 136 nmol L
). The interquartile ranges for vitamin D
supplementation (38.8-71.4 nmol L
, span: 32.6 nmol L
) and UVB irradiation (35.7-65.4 nmol L
, span: 29.7 nmol L
) were similar indicating a comparable response of the two interventions. As the 25(OH)D
start levels (R
= 0.398, P = 3.8 × 10
), 25(OH)D
end levels (R
= 0.457, P = 1.5 × 10
) and Δ25(OH)D
(R
= 0.253, P = 0.028) between both interventions were correlated, this suggested a possible common individual background for the variation. Four pigment SNPs influenced the variation in the vitamin D
-induced and UVB-induced Δ25(OH)D
. A combined model including the influence of these four SNPs and the 25(OH)D
start level explained 86.8% (P = 1.6 × 10
) of the individual variation after vitamin D
supplementation.
The inter-individual variation in the two interventions was comparable and had no common demographic but a partly common genetic background. |
| doi_str_mv | 10.1111/phpp.12491 |
| format | Article |
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increase (Δ25(OH)D
) after vitamin D
supplementation was determined and compared with the UVB irradiation response.
Nineteen Danish participants received 85 μg vitamin D
(cholecalciferol) daily for nine weeks with regular serum 25(OH)D
measurements. These participants had three years earlier taken part in a 9-week controlled UVB study. The Δ25(OH)D
was not confounded by ambient UVB, BMI or ethnicity.
Δ25(OH)D
was 53 nmol L
and almost identical to Δ25(OH)D
(52 nmol L
) after UVB. Δ25(OH)D
ranged from 17 to 91 nmol L
(span 74 nmol L
) and was about half of that observed after UVB irradiation (span 136 nmol L
). The interquartile ranges for vitamin D
supplementation (38.8-71.4 nmol L
, span: 32.6 nmol L
) and UVB irradiation (35.7-65.4 nmol L
, span: 29.7 nmol L
) were similar indicating a comparable response of the two interventions. As the 25(OH)D
start levels (R
= 0.398, P = 3.8 × 10
), 25(OH)D
end levels (R
= 0.457, P = 1.5 × 10
) and Δ25(OH)D
(R
= 0.253, P = 0.028) between both interventions were correlated, this suggested a possible common individual background for the variation. Four pigment SNPs influenced the variation in the vitamin D
-induced and UVB-induced Δ25(OH)D
. A combined model including the influence of these four SNPs and the 25(OH)D
start level explained 86.8% (P = 1.6 × 10
) of the individual variation after vitamin D
supplementation.
The inter-individual variation in the two interventions was comparable and had no common demographic but a partly common genetic background.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1111/phpp.12491</identifier><identifier>PMID: 31166629</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Calcifediol - blood ; Cholecalciferol - administration & dosage ; Female ; Humans ; Male ; Middle Aged ; Seasons ; Ultraviolet Rays - adverse effects</subject><ispartof>Photodermatology, photoimmunology & photomedicine, 2019-09, Vol.35 (5), p.344-353</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c184t-5a5e3b5a05b951e2b91d11facc237d983f37667c0ee77083094732ba6609cc923</citedby><cites>FETCH-LOGICAL-c184t-5a5e3b5a05b951e2b91d11facc237d983f37667c0ee77083094732ba6609cc923</cites><orcidid>0000-0002-9656-733X ; 0000-0002-4395-5232 ; 0000-0001-8060-6413 ; 0000-0001-5590-8671 ; 0000-0002-9463-5087</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31166629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Datta, Pameli</creatorcontrib><creatorcontrib>Philipsen, Peter Alshede</creatorcontrib><creatorcontrib>Olsen, Peter</creatorcontrib><creatorcontrib>Andersen, Jeppe Dyrberg</creatorcontrib><creatorcontrib>Morling, Niels</creatorcontrib><creatorcontrib>Wulf, Hans Christian</creatorcontrib><title>Serum 25(OH)D levels after oral vitamin D 3 supplementation and UVB exposure correlate</title><title>Photodermatology, photoimmunology & photomedicine</title><addtitle>Photodermatol Photoimmunol Photomed</addtitle><description>The inter-individual variation in 25(OH)D
increase (Δ25(OH)D
) after vitamin D
supplementation was determined and compared with the UVB irradiation response.
Nineteen Danish participants received 85 μg vitamin D
(cholecalciferol) daily for nine weeks with regular serum 25(OH)D
measurements. These participants had three years earlier taken part in a 9-week controlled UVB study. The Δ25(OH)D
was not confounded by ambient UVB, BMI or ethnicity.
Δ25(OH)D
was 53 nmol L
and almost identical to Δ25(OH)D
(52 nmol L
) after UVB. Δ25(OH)D
ranged from 17 to 91 nmol L
(span 74 nmol L
) and was about half of that observed after UVB irradiation (span 136 nmol L
). The interquartile ranges for vitamin D
supplementation (38.8-71.4 nmol L
, span: 32.6 nmol L
) and UVB irradiation (35.7-65.4 nmol L
, span: 29.7 nmol L
) were similar indicating a comparable response of the two interventions. As the 25(OH)D
start levels (R
= 0.398, P = 3.8 × 10
), 25(OH)D
end levels (R
= 0.457, P = 1.5 × 10
) and Δ25(OH)D
(R
= 0.253, P = 0.028) between both interventions were correlated, this suggested a possible common individual background for the variation. Four pigment SNPs influenced the variation in the vitamin D
-induced and UVB-induced Δ25(OH)D
. A combined model including the influence of these four SNPs and the 25(OH)D
start level explained 86.8% (P = 1.6 × 10
) of the individual variation after vitamin D
supplementation.
The inter-individual variation in the two interventions was comparable and had no common demographic but a partly common genetic background.</description><subject>Adult</subject><subject>Calcifediol - blood</subject><subject>Cholecalciferol - administration & dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Seasons</subject><subject>Ultraviolet Rays - adverse effects</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90D9PwzAQh2ELgWgpLHwA5BGQUu7ixIlHaIEiVeoA7Ro5zkUE5Y9lJxV8e1oK3HLLq9_wMHaJMMXd3dl3a6cYRgqP2BglQABJisdsDAriIBKpGLEz7z8AIIoAT9lIIEopQzVmm1dyQ8PD-Hq1uJnzmrZUe67LnhzvnK75tup1U7V8zgX3g7U1NdT2uq-6luu24OvNA6dP2_nBETedc1Trns7ZSalrTxe_f8LWT49vs0WwXD2_zO6XgcE06oNYxyTyWEOcqxgpzBUWiKU2JhRJoVJRikTKxABRkkAqQEWJCHMtJShjVCgm7Pawa1znvaMys65qtPvKELI9TrbHyX5wdvHVIbZD3lDxn_5piG_AVF6m</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Datta, Pameli</creator><creator>Philipsen, Peter Alshede</creator><creator>Olsen, Peter</creator><creator>Andersen, Jeppe Dyrberg</creator><creator>Morling, Niels</creator><creator>Wulf, Hans Christian</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-9656-733X</orcidid><orcidid>https://orcid.org/0000-0002-4395-5232</orcidid><orcidid>https://orcid.org/0000-0001-8060-6413</orcidid><orcidid>https://orcid.org/0000-0001-5590-8671</orcidid><orcidid>https://orcid.org/0000-0002-9463-5087</orcidid></search><sort><creationdate>201909</creationdate><title>Serum 25(OH)D levels after oral vitamin D 3 supplementation and UVB exposure correlate</title><author>Datta, Pameli ; Philipsen, Peter Alshede ; Olsen, Peter ; Andersen, Jeppe Dyrberg ; Morling, Niels ; Wulf, Hans Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c184t-5a5e3b5a05b951e2b91d11facc237d983f37667c0ee77083094732ba6609cc923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Calcifediol - blood</topic><topic>Cholecalciferol - administration & dosage</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Seasons</topic><topic>Ultraviolet Rays - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Datta, Pameli</creatorcontrib><creatorcontrib>Philipsen, Peter Alshede</creatorcontrib><creatorcontrib>Olsen, Peter</creatorcontrib><creatorcontrib>Andersen, Jeppe Dyrberg</creatorcontrib><creatorcontrib>Morling, Niels</creatorcontrib><creatorcontrib>Wulf, Hans Christian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Datta, Pameli</au><au>Philipsen, Peter Alshede</au><au>Olsen, Peter</au><au>Andersen, Jeppe Dyrberg</au><au>Morling, Niels</au><au>Wulf, Hans Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum 25(OH)D levels after oral vitamin D 3 supplementation and UVB exposure correlate</atitle><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle><addtitle>Photodermatol Photoimmunol Photomed</addtitle><date>2019-09</date><risdate>2019</risdate><volume>35</volume><issue>5</issue><spage>344</spage><epage>353</epage><pages>344-353</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>The inter-individual variation in 25(OH)D
increase (Δ25(OH)D
) after vitamin D
supplementation was determined and compared with the UVB irradiation response.
Nineteen Danish participants received 85 μg vitamin D
(cholecalciferol) daily for nine weeks with regular serum 25(OH)D
measurements. These participants had three years earlier taken part in a 9-week controlled UVB study. The Δ25(OH)D
was not confounded by ambient UVB, BMI or ethnicity.
Δ25(OH)D
was 53 nmol L
and almost identical to Δ25(OH)D
(52 nmol L
) after UVB. Δ25(OH)D
ranged from 17 to 91 nmol L
(span 74 nmol L
) and was about half of that observed after UVB irradiation (span 136 nmol L
). The interquartile ranges for vitamin D
supplementation (38.8-71.4 nmol L
, span: 32.6 nmol L
) and UVB irradiation (35.7-65.4 nmol L
, span: 29.7 nmol L
) were similar indicating a comparable response of the two interventions. As the 25(OH)D
start levels (R
= 0.398, P = 3.8 × 10
), 25(OH)D
end levels (R
= 0.457, P = 1.5 × 10
) and Δ25(OH)D
(R
= 0.253, P = 0.028) between both interventions were correlated, this suggested a possible common individual background for the variation. Four pigment SNPs influenced the variation in the vitamin D
-induced and UVB-induced Δ25(OH)D
. A combined model including the influence of these four SNPs and the 25(OH)D
start level explained 86.8% (P = 1.6 × 10
) of the individual variation after vitamin D
supplementation.
The inter-individual variation in the two interventions was comparable and had no common demographic but a partly common genetic background.</abstract><cop>England</cop><pmid>31166629</pmid><doi>10.1111/phpp.12491</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9656-733X</orcidid><orcidid>https://orcid.org/0000-0002-4395-5232</orcidid><orcidid>https://orcid.org/0000-0001-8060-6413</orcidid><orcidid>https://orcid.org/0000-0001-5590-8671</orcidid><orcidid>https://orcid.org/0000-0002-9463-5087</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0905-4383 |
| ispartof | Photodermatology, photoimmunology & photomedicine, 2019-09, Vol.35 (5), p.344-353 |
| issn | 0905-4383 1600-0781 |
| language | eng |
| recordid | cdi_crossref_primary_10_1111_phpp_12491 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Calcifediol - blood Cholecalciferol - administration & dosage Female Humans Male Middle Aged Seasons Ultraviolet Rays - adverse effects |
| title | Serum 25(OH)D levels after oral vitamin D 3 supplementation and UVB exposure correlate |
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