Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations

Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations

Summary Background The aim of this study was to develop sunscreen creams containing polymeric nanoparticles (NPs) of naringenin for photoprotective and antioxidant effects. Methods Polymeric NPs of naringenin were prepared and optimized. The NPs were incorporated into sunscreen creams and evaluated...

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Veröffentlicht in:Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2018-01, Vol.34 (1), p.69-81
Hauptverfasser: Joshi, Haritima, Hegde, Aswathi R., Shetty, Pallavi K., Gollavilli, Hemanth, Managuli, Renuka S., Kalthur, Guruprasad, Mutalik, Srinivas
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nanoparticles
naringenin
skin permeation
sun protection factor
sunscreen
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container_end_page 81
container_issue 1
container_start_page 69
container_title Photodermatology, photoimmunology & photomedicine
container_volume 34
creator Joshi, Haritima
Hegde, Aswathi R.
Shetty, Pallavi K.
Gollavilli, Hemanth
Managuli, Renuka S.
Kalthur, Guruprasad
Mutalik, Srinivas
description Summary Background The aim of this study was to develop sunscreen creams containing polymeric nanoparticles (NPs) of naringenin for photoprotective and antioxidant effects. Methods Polymeric NPs of naringenin were prepared and optimized. The NPs were incorporated into sunscreen creams and evaluated for in vitro and in vivo skin retention. Results The optimized naringenin NPs showed a size of 131.2 nm, zeta potential −25.4 mV, and entrapment efficiency 32.45%. The absence of drug‐excipient interaction was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimetry. X‐Ray diffraction analysis demonstrated the amorphization of naringenin in nanoparticles. Transmission electron microscopy showed the sphericity of the NPs with the size of
doi_str_mv 10.1111/phpp.12335
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Methods Polymeric NPs of naringenin were prepared and optimized. The NPs were incorporated into sunscreen creams and evaluated for in vitro and in vivo skin retention. Results The optimized naringenin NPs showed a size of 131.2 nm, zeta potential −25.4 mV, and entrapment efficiency 32.45%. The absence of drug‐excipient interaction was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimetry. X‐Ray diffraction analysis demonstrated the amorphization of naringenin in nanoparticles. Transmission electron microscopy showed the sphericity of the NPs with the size of &lt;200 nm. Cytotoxicity assessment in HaCaT cells indicated non‐toxic nature of naringenin NPs. In vitro skin permeation studies demonstrated that higher amount of naringenin permeated at the end of 12 hours (Q12 hours = 184.03 ± 3.37 μg/cm2) and deposited in the skin (10.38 ± 0.48 μg/cm2) from NPs as compared to plain naringenin. Sunscreen creams (SC1‐SC5) containing plain naringenin or NPs with/without nano‐zinc oxide and nano‐titanium dioxide were prepared and evaluated. Optimized cream (SC5) containing naringenin NPs showed highest SPF value and enhanced skin retention of naringenin in comparison with NPs in suspension form and other cream formulations. Conclusion Optimized nanoparticulate sunscreen cream exhibited highest skin retention and negligible skin permeation of naringenin besides showing excellent SPF value.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1111/phpp.12335</identifier><identifier>PMID: 28767160</identifier><language>eng</language><publisher>England</publisher><subject>nanoparticles ; naringenin ; skin permeation ; sun protection factor ; sunscreen</subject><ispartof>Photodermatology, photoimmunology &amp; photomedicine, 2018-01, Vol.34 (1), p.69-81</ispartof><rights>2017 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><rights>2017 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3295-d0bfbb167fb6eb8b5ed2bf89bd37bdf760e8ac395d9840d4bb75ebde77e06ccd3</citedby><cites>FETCH-LOGICAL-c3295-d0bfbb167fb6eb8b5ed2bf89bd37bdf760e8ac395d9840d4bb75ebde77e06ccd3</cites><orcidid>0000-0002-0642-1928</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fphpp.12335$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fphpp.12335$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28767160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joshi, Haritima</creatorcontrib><creatorcontrib>Hegde, Aswathi R.</creatorcontrib><creatorcontrib>Shetty, Pallavi K.</creatorcontrib><creatorcontrib>Gollavilli, Hemanth</creatorcontrib><creatorcontrib>Managuli, Renuka S.</creatorcontrib><creatorcontrib>Kalthur, Guruprasad</creatorcontrib><creatorcontrib>Mutalik, Srinivas</creatorcontrib><title>Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations</title><title>Photodermatology, photoimmunology &amp; photomedicine</title><addtitle>Photodermatol Photoimmunol Photomed</addtitle><description>Summary Background The aim of this study was to develop sunscreen creams containing polymeric nanoparticles (NPs) of naringenin for photoprotective and antioxidant effects. Methods Polymeric NPs of naringenin were prepared and optimized. The NPs were incorporated into sunscreen creams and evaluated for in vitro and in vivo skin retention. Results The optimized naringenin NPs showed a size of 131.2 nm, zeta potential −25.4 mV, and entrapment efficiency 32.45%. The absence of drug‐excipient interaction was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimetry. X‐Ray diffraction analysis demonstrated the amorphization of naringenin in nanoparticles. Transmission electron microscopy showed the sphericity of the NPs with the size of &lt;200 nm. Cytotoxicity assessment in HaCaT cells indicated non‐toxic nature of naringenin NPs. In vitro skin permeation studies demonstrated that higher amount of naringenin permeated at the end of 12 hours (Q12 hours = 184.03 ± 3.37 μg/cm2) and deposited in the skin (10.38 ± 0.48 μg/cm2) from NPs as compared to plain naringenin. Sunscreen creams (SC1‐SC5) containing plain naringenin or NPs with/without nano‐zinc oxide and nano‐titanium dioxide were prepared and evaluated. Optimized cream (SC5) containing naringenin NPs showed highest SPF value and enhanced skin retention of naringenin in comparison with NPs in suspension form and other cream formulations. Conclusion Optimized nanoparticulate sunscreen cream exhibited highest skin retention and negligible skin permeation of naringenin besides showing excellent SPF value.</description><subject>nanoparticles</subject><subject>naringenin</subject><subject>skin permeation</subject><subject>sun protection factor</subject><subject>sunscreen</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1Lw0AQhhdRbK1e_AGyZyF1N5tkE29SrBUKFtRz2I-JRpLdsJtU-u_dNn7cnMPMO_DwHh6ELimZ0zA33XvXzWnMWHqEpjQjJCI8p8doSgqSRgnL2QSdef9BCEkSQk_RJM55xgM5Re55MF45AIPDFq3Hyppe1KY2b9gIFw6EHKKxnXB9rRrwt3hpXTs0oq-twRq20NiuBdNjYTQO9Lbunf17thbDVjTDgffn6KQSjYeL7ztDr8v7l8UqWj89PC7u1pFicZFGmshKSprxSmYgc5mCjmWVF1IzLnXFMwK5UKxIdZEnRCdS8hSkBs6BZEppNkPXY69y1nsHVdm5uhVuV1JS7sWVe3HlQVyAr0a4G2QL-hf9MRUAOgKfdQO7f6rKzWqzGUu_AHBjfaA</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Joshi, Haritima</creator><creator>Hegde, Aswathi R.</creator><creator>Shetty, Pallavi K.</creator><creator>Gollavilli, Hemanth</creator><creator>Managuli, Renuka S.</creator><creator>Kalthur, Guruprasad</creator><creator>Mutalik, Srinivas</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-0642-1928</orcidid></search><sort><creationdate>201801</creationdate><title>Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations</title><author>Joshi, Haritima ; Hegde, Aswathi R. ; Shetty, Pallavi K. ; Gollavilli, Hemanth ; Managuli, Renuka S. ; Kalthur, Guruprasad ; Mutalik, Srinivas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3295-d0bfbb167fb6eb8b5ed2bf89bd37bdf760e8ac395d9840d4bb75ebde77e06ccd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>nanoparticles</topic><topic>naringenin</topic><topic>skin permeation</topic><topic>sun protection factor</topic><topic>sunscreen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joshi, Haritima</creatorcontrib><creatorcontrib>Hegde, Aswathi R.</creatorcontrib><creatorcontrib>Shetty, Pallavi K.</creatorcontrib><creatorcontrib>Gollavilli, Hemanth</creatorcontrib><creatorcontrib>Managuli, Renuka S.</creatorcontrib><creatorcontrib>Kalthur, Guruprasad</creatorcontrib><creatorcontrib>Mutalik, Srinivas</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Photodermatology, photoimmunology &amp; photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joshi, Haritima</au><au>Hegde, Aswathi R.</au><au>Shetty, Pallavi K.</au><au>Gollavilli, Hemanth</au><au>Managuli, Renuka S.</au><au>Kalthur, Guruprasad</au><au>Mutalik, Srinivas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations</atitle><jtitle>Photodermatology, photoimmunology &amp; photomedicine</jtitle><addtitle>Photodermatol Photoimmunol Photomed</addtitle><date>2018-01</date><risdate>2018</risdate><volume>34</volume><issue>1</issue><spage>69</spage><epage>81</epage><pages>69-81</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>Summary Background The aim of this study was to develop sunscreen creams containing polymeric nanoparticles (NPs) of naringenin for photoprotective and antioxidant effects. Methods Polymeric NPs of naringenin were prepared and optimized. The NPs were incorporated into sunscreen creams and evaluated for in vitro and in vivo skin retention. Results The optimized naringenin NPs showed a size of 131.2 nm, zeta potential −25.4 mV, and entrapment efficiency 32.45%. The absence of drug‐excipient interaction was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimetry. X‐Ray diffraction analysis demonstrated the amorphization of naringenin in nanoparticles. Transmission electron microscopy showed the sphericity of the NPs with the size of &lt;200 nm. Cytotoxicity assessment in HaCaT cells indicated non‐toxic nature of naringenin NPs. In vitro skin permeation studies demonstrated that higher amount of naringenin permeated at the end of 12 hours (Q12 hours = 184.03 ± 3.37 μg/cm2) and deposited in the skin (10.38 ± 0.48 μg/cm2) from NPs as compared to plain naringenin. Sunscreen creams (SC1‐SC5) containing plain naringenin or NPs with/without nano‐zinc oxide and nano‐titanium dioxide were prepared and evaluated. Optimized cream (SC5) containing naringenin NPs showed highest SPF value and enhanced skin retention of naringenin in comparison with NPs in suspension form and other cream formulations. Conclusion Optimized nanoparticulate sunscreen cream exhibited highest skin retention and negligible skin permeation of naringenin besides showing excellent SPF value.</abstract><cop>England</cop><pmid>28767160</pmid><doi>10.1111/phpp.12335</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-0642-1928</orcidid></addata></record>
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subjects nanoparticles
naringenin
skin permeation
sun protection factor
sunscreen
title Sunscreen creams containing naringenin nanoparticles: Formulation development and in vitro and in vivo evaluations
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