Pharmacokinetic/pharmacodynamic evaluation of grapiprant in a carrageenan‐induced inflammatory pain model in the rabbit

Grapiprant is the novel selective EP4 receptor inhibitor recently issued on the veterinary market for dogs affected by osteoarthritis. The aim of this study was twofold: to evaluate the pharmacokinetics and the pharmacodynamics of grapiprant in the induced inflammatory pain model in the rabbit after...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2017-10, Vol.40 (5), p.468-475
Hauptverfasser:	De Vito, V., Salvadori, M., Poapolathep, A., Owen, H., Rychshanova, R., Giorgi, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrageenan - administration & dosage Cross-Over Studies Disease Models, Animal Dogs Osteoarthritis - chemically induced Osteoarthritis - drug therapy Osteoarthritis - veterinary Pain - chemically induced Pain - drug therapy Pain - veterinary Rabbits Random Allocation Sulfonylurea Compounds - pharmacokinetics Sulfonylurea Compounds - pharmacology Treatment Outcome
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