Enhancement of high glucose-induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT 2 /Akt/NF-κB pathway

Hyperglycemia is a representative hallmark and risk factor for diabetes mellitus (DM) and is closely linked to DM-associated neuronal cell death. Previous investigators reported on a genome-wide association study and showed relationships between DM and melatonin receptor (MT), highlighting the role...

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Veröffentlicht in:	Journal of pineal research 2017-09, Vol.63 (2)
Hauptverfasser:	Onphachanh, Xaykham, Lee, Hyun Jik, Lim, Jae Ryong, Jung, Young Hyun, Kim, Jun Sung, Chae, Chang Woo, Lee, Sei-Jung, Gabr, Amr Ahmed, Han, Ho Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Line, Tumor Cell Survival - drug effects Gene Expression Regulation, Enzymologic - drug effects Glucose - pharmacology Humans Melatonin - pharmacology Neurons - cytology Neurons - metabolism NF-kappa B - metabolism Protein Kinases - biosynthesis Proto-Oncogene Proteins c-akt - metabolism Receptor, Melatonin, MT2 - metabolism Signal Transduction - drug effects
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