Assessment of efficacy and tolerability of different concentrations of trichloroacetic acid vs. carbon dioxide laser in treatment of xanthelasma palpebrarum
Summary Background There are numerous methods currently available for the management of xanthelasma. These include surgical excision, laser ablation using a variety of lasers and chemical cauterization. However, each method of treatment is associated with particular limitations and side effects. Obj...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2015-09, Vol.14 (3), p.209-215 |
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| container_title | Journal of cosmetic dermatology |
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| creator | Mourad, Basma Elgarhy, Lamia H. Ellakkawy, Heba-Alla Elmahdy, Nageh |
| description | Summary
Background
There are numerous methods currently available for the management of xanthelasma. These include surgical excision, laser ablation using a variety of lasers and chemical cauterization. However, each method of treatment is associated with particular limitations and side effects.
Objectives
To assess the clinical efficacy and tolerability of different concentrations of topical trichloroacetic acid (TCA) vs. carbon dioxide laser in the treatment of patients with xanthelasma palpebrarum.
Methods
Thirty patients with xanthelasma palpebrarum were classified into four groups, treated by TCA 35%, 50%, 70%, and CO2 laser, respectively. Lipid profile was estimated for all patients.
Results
Both TCA peeling 70% and carbon dioxide laser ablation showed more significant clinical efficacy and tolerability with least number of sessions in the treatment of xanthelasma palpebrarum than 50% and 35% TCA peeling. Post‐therapy erythema and hypopigmentation were more with TCA 70%. Post‐therapy hyperpigmentation was more with TCA (50%). There was a significant improvement in patients with normal lipid profile than those with abnormal profile.
Conclusion
Both TCA peeling 70% and carbon dioxide laser ablation are highly effective and well tolerated with least number of sessions in the treatment of xanthelasma palpebrarum. |
| doi_str_mv | 10.1111/jocd.12148 |
| format | Article |
| fullrecord | <record><control><sourceid>istex_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1111_jocd_12148</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ark_67375_WNG_50T7JGGG_X</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4378-b19b341ee569390a4b3468010e5105f17f2a782a495c06095ca520514dd222763</originalsourceid><addsrcrecordid>eNp9kM1u1DAUhS0Eoj-w4QGQ10gZ_BPHk2U1QEpV0U0R7Kwb51p1SeKR7cLMu_CwOAwzS7zwvdb5zrF0CHnD2YqX8_4x2GHFBa_Xz8g5r7WsBG_U89Mu2Rm5SOmRMa5brl6SM9EIxaWU5-T3VUqY0oRzpsFRdM5bsHsK80BzGDFC70ef94s4eOcwLqQNsy0zQvZhTouWo7cPY4gBLGZvKVg_0J9pRS3EPszFG3Z-QDpCwkj9XAwI-fjtDub8gEWbgG5h3GIfIT5Nr8gLB2PC1__mJfn66eP95rq6ves-b65uK1tLva563vay5oiqaWXLoC6vZs04Q8WZclw7AXotoG6VZQ0rNyjBFK-HQQihG3lJ3h1ybQwpRXRmG_0EcW84M0vFZqnY_K24wG8P8Papn3A4ocdOC8APwC8_4v4_UebmbvPhGFodPD5l3J08EH-YRkutzLcvnVHsXt90XWe-yz_xtJhg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Assessment of efficacy and tolerability of different concentrations of trichloroacetic acid vs. carbon dioxide laser in treatment of xanthelasma palpebrarum</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Mourad, Basma ; Elgarhy, Lamia H. ; Ellakkawy, Heba-Alla ; Elmahdy, Nageh</creator><creatorcontrib>Mourad, Basma ; Elgarhy, Lamia H. ; Ellakkawy, Heba-Alla ; Elmahdy, Nageh</creatorcontrib><description>Summary
Background
There are numerous methods currently available for the management of xanthelasma. These include surgical excision, laser ablation using a variety of lasers and chemical cauterization. However, each method of treatment is associated with particular limitations and side effects.
Objectives
To assess the clinical efficacy and tolerability of different concentrations of topical trichloroacetic acid (TCA) vs. carbon dioxide laser in the treatment of patients with xanthelasma palpebrarum.
Methods
Thirty patients with xanthelasma palpebrarum were classified into four groups, treated by TCA 35%, 50%, 70%, and CO2 laser, respectively. Lipid profile was estimated for all patients.
Results
Both TCA peeling 70% and carbon dioxide laser ablation showed more significant clinical efficacy and tolerability with least number of sessions in the treatment of xanthelasma palpebrarum than 50% and 35% TCA peeling. Post‐therapy erythema and hypopigmentation were more with TCA 70%. Post‐therapy hyperpigmentation was more with TCA (50%). There was a significant improvement in patients with normal lipid profile than those with abnormal profile.
Conclusion
Both TCA peeling 70% and carbon dioxide laser ablation are highly effective and well tolerated with least number of sessions in the treatment of xanthelasma palpebrarum.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.12148</identifier><identifier>PMID: 26251333</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Administration, Cutaneous ; Adult ; Chemexfoliation ; CO2 laser ; Dermatologic Agents - administration & dosage ; Dermatologic Agents - adverse effects ; efficacy ; Erythema - etiology ; Facial Dermatoses - drug therapy ; Facial Dermatoses - metabolism ; Facial Dermatoses - therapy ; Female ; Humans ; Hypopigmentation - etiology ; Lasers, Gas - adverse effects ; Lasers, Gas - therapeutic use ; Lipid Metabolism ; trichloroacetic acid ; Trichloroacetic Acid - administration & dosage ; Trichloroacetic Acid - adverse effects ; Xanthomatosis - drug therapy ; Xanthomatosis - metabolism ; Xanthomatosis - therapy</subject><ispartof>Journal of cosmetic dermatology, 2015-09, Vol.14 (3), p.209-215</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4378-b19b341ee569390a4b3468010e5105f17f2a782a495c06095ca520514dd222763</citedby><cites>FETCH-LOGICAL-c4378-b19b341ee569390a4b3468010e5105f17f2a782a495c06095ca520514dd222763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.12148$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocd.12148$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26251333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mourad, Basma</creatorcontrib><creatorcontrib>Elgarhy, Lamia H.</creatorcontrib><creatorcontrib>Ellakkawy, Heba-Alla</creatorcontrib><creatorcontrib>Elmahdy, Nageh</creatorcontrib><title>Assessment of efficacy and tolerability of different concentrations of trichloroacetic acid vs. carbon dioxide laser in treatment of xanthelasma palpebrarum</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Summary
Background
There are numerous methods currently available for the management of xanthelasma. These include surgical excision, laser ablation using a variety of lasers and chemical cauterization. However, each method of treatment is associated with particular limitations and side effects.
Objectives
To assess the clinical efficacy and tolerability of different concentrations of topical trichloroacetic acid (TCA) vs. carbon dioxide laser in the treatment of patients with xanthelasma palpebrarum.
Methods
Thirty patients with xanthelasma palpebrarum were classified into four groups, treated by TCA 35%, 50%, 70%, and CO2 laser, respectively. Lipid profile was estimated for all patients.
Results
Both TCA peeling 70% and carbon dioxide laser ablation showed more significant clinical efficacy and tolerability with least number of sessions in the treatment of xanthelasma palpebrarum than 50% and 35% TCA peeling. Post‐therapy erythema and hypopigmentation were more with TCA 70%. Post‐therapy hyperpigmentation was more with TCA (50%). There was a significant improvement in patients with normal lipid profile than those with abnormal profile.
Conclusion
Both TCA peeling 70% and carbon dioxide laser ablation are highly effective and well tolerated with least number of sessions in the treatment of xanthelasma palpebrarum.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Chemexfoliation</subject><subject>CO2 laser</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Dermatologic Agents - adverse effects</subject><subject>efficacy</subject><subject>Erythema - etiology</subject><subject>Facial Dermatoses - drug therapy</subject><subject>Facial Dermatoses - metabolism</subject><subject>Facial Dermatoses - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Hypopigmentation - etiology</subject><subject>Lasers, Gas - adverse effects</subject><subject>Lasers, Gas - therapeutic use</subject><subject>Lipid Metabolism</subject><subject>trichloroacetic acid</subject><subject>Trichloroacetic Acid - administration & dosage</subject><subject>Trichloroacetic Acid - adverse effects</subject><subject>Xanthomatosis - drug therapy</subject><subject>Xanthomatosis - metabolism</subject><subject>Xanthomatosis - therapy</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAUhS0Eoj-w4QGQ10gZ_BPHk2U1QEpV0U0R7Kwb51p1SeKR7cLMu_CwOAwzS7zwvdb5zrF0CHnD2YqX8_4x2GHFBa_Xz8g5r7WsBG_U89Mu2Rm5SOmRMa5brl6SM9EIxaWU5-T3VUqY0oRzpsFRdM5bsHsK80BzGDFC70ef94s4eOcwLqQNsy0zQvZhTouWo7cPY4gBLGZvKVg_0J9pRS3EPszFG3Z-QDpCwkj9XAwI-fjtDub8gEWbgG5h3GIfIT5Nr8gLB2PC1__mJfn66eP95rq6ves-b65uK1tLva563vay5oiqaWXLoC6vZs04Q8WZclw7AXotoG6VZQ0rNyjBFK-HQQihG3lJ3h1ybQwpRXRmG_0EcW84M0vFZqnY_K24wG8P8Papn3A4ocdOC8APwC8_4v4_UebmbvPhGFodPD5l3J08EH-YRkutzLcvnVHsXt90XWe-yz_xtJhg</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Mourad, Basma</creator><creator>Elgarhy, Lamia H.</creator><creator>Ellakkawy, Heba-Alla</creator><creator>Elmahdy, Nageh</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201509</creationdate><title>Assessment of efficacy and tolerability of different concentrations of trichloroacetic acid vs. carbon dioxide laser in treatment of xanthelasma palpebrarum</title><author>Mourad, Basma ; Elgarhy, Lamia H. ; Ellakkawy, Heba-Alla ; Elmahdy, Nageh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4378-b19b341ee569390a4b3468010e5105f17f2a782a495c06095ca520514dd222763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Chemexfoliation</topic><topic>CO2 laser</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Dermatologic Agents - adverse effects</topic><topic>efficacy</topic><topic>Erythema - etiology</topic><topic>Facial Dermatoses - drug therapy</topic><topic>Facial Dermatoses - metabolism</topic><topic>Facial Dermatoses - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Hypopigmentation - etiology</topic><topic>Lasers, Gas - adverse effects</topic><topic>Lasers, Gas - therapeutic use</topic><topic>Lipid Metabolism</topic><topic>trichloroacetic acid</topic><topic>Trichloroacetic Acid - administration & dosage</topic><topic>Trichloroacetic Acid - adverse effects</topic><topic>Xanthomatosis - drug therapy</topic><topic>Xanthomatosis - metabolism</topic><topic>Xanthomatosis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mourad, Basma</creatorcontrib><creatorcontrib>Elgarhy, Lamia H.</creatorcontrib><creatorcontrib>Ellakkawy, Heba-Alla</creatorcontrib><creatorcontrib>Elmahdy, Nageh</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mourad, Basma</au><au>Elgarhy, Lamia H.</au><au>Ellakkawy, Heba-Alla</au><au>Elmahdy, Nageh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of efficacy and tolerability of different concentrations of trichloroacetic acid vs. carbon dioxide laser in treatment of xanthelasma palpebrarum</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2015-09</date><risdate>2015</risdate><volume>14</volume><issue>3</issue><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Summary
Background
There are numerous methods currently available for the management of xanthelasma. These include surgical excision, laser ablation using a variety of lasers and chemical cauterization. However, each method of treatment is associated with particular limitations and side effects.
Objectives
To assess the clinical efficacy and tolerability of different concentrations of topical trichloroacetic acid (TCA) vs. carbon dioxide laser in the treatment of patients with xanthelasma palpebrarum.
Methods
Thirty patients with xanthelasma palpebrarum were classified into four groups, treated by TCA 35%, 50%, 70%, and CO2 laser, respectively. Lipid profile was estimated for all patients.
Results
Both TCA peeling 70% and carbon dioxide laser ablation showed more significant clinical efficacy and tolerability with least number of sessions in the treatment of xanthelasma palpebrarum than 50% and 35% TCA peeling. Post‐therapy erythema and hypopigmentation were more with TCA 70%. Post‐therapy hyperpigmentation was more with TCA (50%). There was a significant improvement in patients with normal lipid profile than those with abnormal profile.
Conclusion
Both TCA peeling 70% and carbon dioxide laser ablation are highly effective and well tolerated with least number of sessions in the treatment of xanthelasma palpebrarum.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26251333</pmid><doi>10.1111/jocd.12148</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of cosmetic dermatology, 2015-09, Vol.14 (3), p.209-215 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Administration, Cutaneous Adult Chemexfoliation CO2 laser Dermatologic Agents - administration & dosage Dermatologic Agents - adverse effects efficacy Erythema - etiology Facial Dermatoses - drug therapy Facial Dermatoses - metabolism Facial Dermatoses - therapy Female Humans Hypopigmentation - etiology Lasers, Gas - adverse effects Lasers, Gas - therapeutic use Lipid Metabolism trichloroacetic acid Trichloroacetic Acid - administration & dosage Trichloroacetic Acid - adverse effects Xanthomatosis - drug therapy Xanthomatosis - metabolism Xanthomatosis - therapy |
| title | Assessment of efficacy and tolerability of different concentrations of trichloroacetic acid vs. carbon dioxide laser in treatment of xanthelasma palpebrarum |
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