Ectopic germline recombination activity of the widely used Foxp3‐YFP‐Cre mouse: a case report

Summary Regulatory T (Treg) cell‐specific deletion of a gene of interest is a procedure widely used to study mechanisms controlling Treg development, homeostasis and function. Accordingly, several transgenic mouse lines have been generated that bear the Cre recombinase under control of the Foxp3 pro...

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Veröffentlicht in:	Immunology 2020-02, Vol.159 (2), p.231-241
Hauptverfasser:	Wu, Dan, Huang, Qing, Orban, Paul C., Levings, Megan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Case reports Cell Lineage Clonal deletion Cre recombinase Cre recombination Crosses, Genetic Forkhead Transcription Factors - genetics Foxp3 Foxp3 protein Gene deletion Genes, Reporter Genetic crosses Genotype Genotypes Genotyping Homeostasis Insertion Insulin Integrases - genetics Integrases - metabolism Luminescent Proteins - biosynthesis Luminescent Proteins - genetics Lymphocytes T Mice, Knockout Mice, Transgenic mouse Offspring Original Phenotype Polymerase Chain Reaction - methods Promoter Regions, Genetic Receptor, Insulin - deficiency Receptor, Insulin - genetics Recombination Recombination, Genetic regulatory T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transgenic mice
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