Epigenetic modifications of the V H region after DJ H recombination in Pro-B cells

The variable region of murine immunoglobulin heavy chain (Igh) is assembled by sequential D -J and V -DJ recombination. The accessibility of the Igh locus determines the order of rearrangement. Because of the large number of V genes and the lack of a suitable model, the epigenetic modifications of V...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunology 2017-10, Vol.152 (2), p.218-231
Hauptverfasser:	Dong, Yanying, Wu, Caijun, Zhao, Xiaohui, Zhang, Ping, Zhang, Hua, Zheng, Mingzhe, Li, Shichang, Jiao, Junna, Yu, Xiaozhuo, Lv, Zhuangwei, Ji, Yanhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Cell Line, Transformed Chromatin Immunoprecipitation DNA-Binding Proteins - immunology DNA-Binding Proteins - metabolism Epigenesis, Genetic Gene Rearrangement, B-Lymphocyte Genes, abl Genes, Immunoglobulin Heavy Chain HEK293 Cells Histones - metabolism Homeodomain Proteins - immunology Homeodomain Proteins - metabolism Humans Immunoglobulin Joining Region - genetics Immunoglobulin Joining Region - immunology Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - immunology Immunoglobulin Variable Region - metabolism Methylation Mice Mice, Inbred C57BL PAX5 Transcription Factor - genetics PAX5 Transcription Factor - metabolism Precursor Cells, B-Lymphoid - immunology Precursor Cells, B-Lymphoid - metabolism Protein Binding Protein Processing, Post-Translational Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!