In vitro ‐generated MART ‐1‐specific CD 8 T cells display a broader T‐cell receptor repertoire than ex vivo naïve and tumor‐infiltrating lymphocytes

The differentiation of human hematopoietic stem cells into CD 8 T cells can be achieved in vitro with the OP 9‐ DL 4 system. We considered that in the absence of medullary thymic epithelial cells, which serve to restrict the breath of the T‐cell receptor ( TCR ) repertoire by expressing tissue‐restr...

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Veröffentlicht in:	Immunology and cell biology 2019-04, Vol.97 (4), p.427-434
Hauptverfasser:	Benveniste, Patricia M, Nakatsugawa, Munehide, Nguyen, Linh, Ohashi, Pamela S, Hirano, Naoto, Zúñiga‐Pflücker, Juan Carlos
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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