Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats
Summary Guggul tree or Commiphora mukul is a small thorny herb having remarkable hypocholesterolaemic properties. Its therapeutic effects are because of its biocomponent guggulsterones, especially guggulsterone E and Z. In this research, double emulsion‐based spread was tried to improve the bioavail...
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| Veröffentlicht in: | International journal of food science & technology 2018-03, Vol.53 (3), p.626-633 |
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| container_title | International journal of food science & technology |
| container_volume | 53 |
| creator | Lamba, Heena Sabikhi, Latha Aggarwal, Dipesh Choudhary, Urmila Reddi, Srinu Kapila, Suman Kapila, Rajeev |
| description | Summary
Guggul tree or Commiphora mukul is a small thorny herb having remarkable hypocholesterolaemic properties. Its therapeutic effects are because of its biocomponent guggulsterones, especially guggulsterone E and Z. In this research, double emulsion‐based spread was tried to improve the bioavailability of the herb guggul in in vivo rat model. The effect of the different diets with encapsulated and nonencapsulated guggul was evaluated and compared after 6 weeks, based on the final body weight and analysis of organs, serum and faeces of normal and hypercholesterolaemic (H) rats. It was evident from the results that double emulsion‐encapsulated guggul showed better control on weight of H rats (25.98% lower), inhibition of HMG CoA reductase (3.95 times less) activity and reduction in atherosclerotic index (47.2%), as compared to diet with unencapsulated guggul. Encapsulation of guggul also improved faecal excretion of bile acids, lipids and total cholesterol in H and normal rats.
Encapsulation of guggul extract in double emulsion system improved its hypocholesterolaemic action in rats. Encapsulated guggul administered through diet for 6 weeks showed better results than its non‐encapsulated form. |
| doi_str_mv | 10.1111/ijfs.13637 |
| format | Article |
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Guggul tree or Commiphora mukul is a small thorny herb having remarkable hypocholesterolaemic properties. Its therapeutic effects are because of its biocomponent guggulsterones, especially guggulsterone E and Z. In this research, double emulsion‐based spread was tried to improve the bioavailability of the herb guggul in in vivo rat model. The effect of the different diets with encapsulated and nonencapsulated guggul was evaluated and compared after 6 weeks, based on the final body weight and analysis of organs, serum and faeces of normal and hypercholesterolaemic (H) rats. It was evident from the results that double emulsion‐encapsulated guggul showed better control on weight of H rats (25.98% lower), inhibition of HMG CoA reductase (3.95 times less) activity and reduction in atherosclerotic index (47.2%), as compared to diet with unencapsulated guggul. Encapsulation of guggul also improved faecal excretion of bile acids, lipids and total cholesterol in H and normal rats.
Encapsulation of guggul extract in double emulsion system improved its hypocholesterolaemic action in rats. Encapsulated guggul administered through diet for 6 weeks showed better results than its non‐encapsulated form.</description><identifier>ISSN: 0950-5423</identifier><identifier>EISSN: 1365-2621</identifier><identifier>DOI: 10.1111/ijfs.13637</identifier><language>eng</language><subject>Bioavailability ; double emulsion ; faecal bile acids ; guggul ; herb ; HMG CoA reductase</subject><ispartof>International journal of food science & technology, 2018-03, Vol.53 (3), p.626-633</ispartof><rights>2017 Institute of Food Science and Technology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2277-bb6b07a1b2b66d6ba243ec51d2c6404eb97a0977af3cb310866033b7b2dd80ba3</citedby><cites>FETCH-LOGICAL-c2277-bb6b07a1b2b66d6ba243ec51d2c6404eb97a0977af3cb310866033b7b2dd80ba3</cites><orcidid>0000-0003-3011-6146</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijfs.13637$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijfs.13637$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Lamba, Heena</creatorcontrib><creatorcontrib>Sabikhi, Latha</creatorcontrib><creatorcontrib>Aggarwal, Dipesh</creatorcontrib><creatorcontrib>Choudhary, Urmila</creatorcontrib><creatorcontrib>Reddi, Srinu</creatorcontrib><creatorcontrib>Kapila, Suman</creatorcontrib><creatorcontrib>Kapila, Rajeev</creatorcontrib><title>Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats</title><title>International journal of food science & technology</title><description>Summary
Guggul tree or Commiphora mukul is a small thorny herb having remarkable hypocholesterolaemic properties. Its therapeutic effects are because of its biocomponent guggulsterones, especially guggulsterone E and Z. In this research, double emulsion‐based spread was tried to improve the bioavailability of the herb guggul in in vivo rat model. The effect of the different diets with encapsulated and nonencapsulated guggul was evaluated and compared after 6 weeks, based on the final body weight and analysis of organs, serum and faeces of normal and hypercholesterolaemic (H) rats. It was evident from the results that double emulsion‐encapsulated guggul showed better control on weight of H rats (25.98% lower), inhibition of HMG CoA reductase (3.95 times less) activity and reduction in atherosclerotic index (47.2%), as compared to diet with unencapsulated guggul. Encapsulation of guggul also improved faecal excretion of bile acids, lipids and total cholesterol in H and normal rats.
Encapsulation of guggul extract in double emulsion system improved its hypocholesterolaemic action in rats. Encapsulated guggul administered through diet for 6 weeks showed better results than its non‐encapsulated form.</description><subject>Bioavailability</subject><subject>double emulsion</subject><subject>faecal bile acids</subject><subject>guggul</subject><subject>herb</subject><subject>HMG CoA reductase</subject><issn>0950-5423</issn><issn>1365-2621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OwzAUhS0EEqWw8ASekVL8k9jtiAotRZUYgDmynZvWlVNHdlLIxiPwCDwLj8KTkFJm7nKG-50zfAhdUjKi_V3bTRlHlAsuj9CgzyxhgtFjNCCTjCRZyvgpOotxQwhhXKYDVNz6VjvAULUuWr_9fv-ArVF1bJ1qoMCrdrVqHYa3tdW2idhWdfC7_mG3X587u_N43dXerL2D2EDwTkFlDVam6cd6CAfVxHN0UioX4eIvh-hldvc8vU-Wj_PF9GaZGMakTLQWmkhFNdNCFEIrlnIwGS2YESlJQU-kIhMpVcmN5pSMhSCca6lZUYyJVnyIrg67JvgYA5R5HWylQpdTku_95Hs_-a-fHqYH-NU66P4h88XD7OnQ-QFwhW0U</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Lamba, Heena</creator><creator>Sabikhi, Latha</creator><creator>Aggarwal, Dipesh</creator><creator>Choudhary, Urmila</creator><creator>Reddi, Srinu</creator><creator>Kapila, Suman</creator><creator>Kapila, Rajeev</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-3011-6146</orcidid></search><sort><creationdate>201803</creationdate><title>Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats</title><author>Lamba, Heena ; Sabikhi, Latha ; Aggarwal, Dipesh ; Choudhary, Urmila ; Reddi, Srinu ; Kapila, Suman ; Kapila, Rajeev</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2277-bb6b07a1b2b66d6ba243ec51d2c6404eb97a0977af3cb310866033b7b2dd80ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bioavailability</topic><topic>double emulsion</topic><topic>faecal bile acids</topic><topic>guggul</topic><topic>herb</topic><topic>HMG CoA reductase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamba, Heena</creatorcontrib><creatorcontrib>Sabikhi, Latha</creatorcontrib><creatorcontrib>Aggarwal, Dipesh</creatorcontrib><creatorcontrib>Choudhary, Urmila</creatorcontrib><creatorcontrib>Reddi, Srinu</creatorcontrib><creatorcontrib>Kapila, Suman</creatorcontrib><creatorcontrib>Kapila, Rajeev</creatorcontrib><collection>CrossRef</collection><jtitle>International journal of food science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamba, Heena</au><au>Sabikhi, Latha</au><au>Aggarwal, Dipesh</au><au>Choudhary, Urmila</au><au>Reddi, Srinu</au><au>Kapila, Suman</au><au>Kapila, Rajeev</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats</atitle><jtitle>International journal of food science & technology</jtitle><date>2018-03</date><risdate>2018</risdate><volume>53</volume><issue>3</issue><spage>626</spage><epage>633</epage><pages>626-633</pages><issn>0950-5423</issn><eissn>1365-2621</eissn><abstract>Summary
Guggul tree or Commiphora mukul is a small thorny herb having remarkable hypocholesterolaemic properties. Its therapeutic effects are because of its biocomponent guggulsterones, especially guggulsterone E and Z. In this research, double emulsion‐based spread was tried to improve the bioavailability of the herb guggul in in vivo rat model. The effect of the different diets with encapsulated and nonencapsulated guggul was evaluated and compared after 6 weeks, based on the final body weight and analysis of organs, serum and faeces of normal and hypercholesterolaemic (H) rats. It was evident from the results that double emulsion‐encapsulated guggul showed better control on weight of H rats (25.98% lower), inhibition of HMG CoA reductase (3.95 times less) activity and reduction in atherosclerotic index (47.2%), as compared to diet with unencapsulated guggul. Encapsulation of guggul also improved faecal excretion of bile acids, lipids and total cholesterol in H and normal rats.
Encapsulation of guggul extract in double emulsion system improved its hypocholesterolaemic action in rats. Encapsulated guggul administered through diet for 6 weeks showed better results than its non‐encapsulated form.</abstract><doi>10.1111/ijfs.13637</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3011-6146</orcidid></addata></record> |
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| ispartof | International journal of food science & technology, 2018-03, Vol.53 (3), p.626-633 |
| issn | 0950-5423 1365-2621 |
| language | eng |
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| source | Oxford Journals Open Access Collection; Wiley Online Library Journals Frontfile Complete |
| subjects | Bioavailability double emulsion faecal bile acids guggul herb HMG CoA reductase |
| title | Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats |
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