The circular RNA ci RS ‐7 promotes APP and BACE 1 degradation in an NF ‐κB‐dependent manner

The aberrant accumulation of β‐amyloid peptide (Aβ) in the brain is a key feature of Alzheimer's disease ( AD ), and enhanced cleavage of β‐amyloid precursor protein ( APP ) by β‐site APP ‐cleaving enzyme 1 ( BACE 1) has a major causative role in AD . Despite their prominence in AD pathogenesis...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The FEBS journal 2017-04, Vol.284 (7), p.1096-1109
Hauptverfasser:	Shi, Zhemin, Chen, Ting, Yao, Qingbin, Zheng, Lina, Zhang, Zhen, Wang, Jingzhao, Hu, Zhimei, Cui, Hongmei, Han, Yawei, Han, Xiaohui, Zhang, Kun, Hong, Wei
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!