The 5-HT 1A receptor agonist, 8-OH-DPAT, attenuates long-lasting pain in imiquimod-induced psoriasis in mice

Psoriasis pain is a common symptom underestimated and rarely evaluated in psoriasis clinical trials. This work aimed to investigate whether the development of secondary chronic allodynia and hyperalgesia in the imiquimod (IMQ)-induced psoriasis mice model could be modulated by anti-inflammatory agen...

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Veröffentlicht in:	Experimental dermatology 2022-04, Vol.31 (4), p.600-607
Hauptverfasser:	Cervantes-Durán, Claudia, Avalos-Viveros, Miguel, Torner, Luz, Sánchez-Ceja, Sandra-Guadalupe, Rodríguez-Orozco, Alain-Raimundo, Martínez-Flores, Héctor-Eduardo, García-Pérez, Martha-Estrella
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology 8-Hydroxy-2-(di-n-propylamino)tetralin - therapeutic use Animals Chronic Pain Hyperalgesia - chemically induced Hyperalgesia - drug therapy Imiquimod Male Mice Mice, Inbred C57BL Psoriasis - chemically induced Psoriasis - complications Psoriasis - drug therapy Receptor, Serotonin, 5-HT1A Serotonin Serotonin Receptor Agonists - pharmacology Serotonin Receptor Agonists - therapeutic use
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