Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABA ergic inhibitory transmission on dorsal horn rat neurons

Corticosterone ( CORT ) is a glucocorticoid produced by adrenal glands under the control of the hypothalamic–pituitary–adrenal axis. Circulating CORT can enter the central nervous system and be reduced to neuroactive 3α5α‐reduced steroids, which modulate GABA A receptors. In the dorsal spinal cord,...

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Veröffentlicht in:	The European journal of neuroscience 2015-02, Vol.41 (3), p.390-397
Hauptverfasser:	Zell, Vivien, Juif, Pierre‐Éric, Hanesch, Ulrike, Poisbeau, Pierrick, Anton, Fernand, Darbon, Pascal
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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