Longitudinal assessment of bone growth and development in a facility‐based population of young adults with cerebral palsy
Aim Osteoporosis is a significant clinical problem in persons with moderate to severe cerebral palsy (CP), causing fractures with minimal trauma. Over the past decade, most studies examining osteoporosis and CP have been cross‐sectional in nature, focused exclusively on children and adolescents and...
Gespeichert in:
| Veröffentlicht in: | Developmental medicine and child neurology 2015-11, Vol.57 (11), p.1064-1069 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1069 |
|---|---|
| container_issue | 11 |
| container_start_page | 1064 |
| container_title | Developmental medicine and child neurology |
| container_volume | 57 |
| creator | Grossberg, Richard Blackford, Martha G Kecskemethy, Heidi H Henderson, Richard Reed, Michael D |
| description | Aim
Osteoporosis is a significant clinical problem in persons with moderate to severe cerebral palsy (CP), causing fractures with minimal trauma. Over the past decade, most studies examining osteoporosis and CP have been cross‐sectional in nature, focused exclusively on children and adolescents and only involving one evaluation of bone mineral density (BMD). The purpose of this study was to assess BMD in a group including adults with CP, and changes in each individual's BMD over a 5‐ to 6‐year period.
Method
The study group included 40 residents of a long‐term care facility aged 6 to 26 years at the time of their initial evaluation. Twenty‐one patients (52.5%) were male, 35 (88%) were white, and 38 (95%) were in Gross Motor Function Classification System level V. BMD was assessed by dual‐energy X‐ray absorptiometry on the right and left distal femurs for three distinct regions of interest.
Results
Five residents had a fracture that occurred during the study period; this represented a fracture rate of 2.1% per year in the study group. Longitudinally, annualized change in the median BMD was 0.7% to 1.0% per year in the different regions of the distal femur, but ranged widely among the study group, with both increases and decreases in BMD. Increase in BMD over time was negatively correlated with age and positively correlated with change in weight.
Interpretation
Changes in BMD over time in profoundly involved persons with CP can range widely, which is important to recognize when evaluating potential interventions to improve BMD. Age and changes in body weight appear the most relevant factors.
What this paper adds
In a cohort of patients with severe cerebral palsy, median change in bone mineral density (BMD) was less than previously described.
Age was negatively correlated with mean annualized percentage change in BMD.
Weight was positively correlated with BMD.
Change in weight was positively correlated with change in BMD. |
| doi_str_mv | 10.1111/dmcn.12790 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1111_dmcn_12790</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>DMCN12790</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4350-cd01bd30d85b32147cf0d4bd656637f51a5184a779abfcc3bcf64475a265290a3</originalsourceid><addsrcrecordid>eNp9kLtOwzAUhi0EglJYeADkGSnFdmynGVG5SgUWmCNfi1FiR3FCFbHwCDwjT0LaACNn-Yfznf9IHwAnGM3wMOe6Un6GSZajHTDBlOfJPKP5LpgghEmCOSEH4DDGV4RQyhndBweE5QwTiibgfRn8yrWddl6UUMRoYqyMb2GwUAZv4KoJ6_YFCq-hNm-mDPV27TwU0ArlStf2Xx-fUkSjYR3qrhStC35z34fOr6DQXdlGuHZDizKNkc3wqBZl7I_Anh3SHP_kFDxfXz0tbpPl483d4mKZKJoylCiNsNQp0nMmU4JppizSVGrOOE8zy7BgeE5FluVCWqVSqSynNGOCcEZyJNIpOBt7VRNibIwt6sZVoukLjIqNwWJjsNgaHODTEa47WRn9h_4qGwA8AmtXmv6fquLyfvEwln4DvJJ_PQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Longitudinal assessment of bone growth and development in a facility‐based population of young adults with cerebral palsy</title><source>MEDLINE</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>Grossberg, Richard ; Blackford, Martha G ; Kecskemethy, Heidi H ; Henderson, Richard ; Reed, Michael D</creator><creatorcontrib>Grossberg, Richard ; Blackford, Martha G ; Kecskemethy, Heidi H ; Henderson, Richard ; Reed, Michael D</creatorcontrib><description>Aim
Osteoporosis is a significant clinical problem in persons with moderate to severe cerebral palsy (CP), causing fractures with minimal trauma. Over the past decade, most studies examining osteoporosis and CP have been cross‐sectional in nature, focused exclusively on children and adolescents and only involving one evaluation of bone mineral density (BMD). The purpose of this study was to assess BMD in a group including adults with CP, and changes in each individual's BMD over a 5‐ to 6‐year period.
Method
The study group included 40 residents of a long‐term care facility aged 6 to 26 years at the time of their initial evaluation. Twenty‐one patients (52.5%) were male, 35 (88%) were white, and 38 (95%) were in Gross Motor Function Classification System level V. BMD was assessed by dual‐energy X‐ray absorptiometry on the right and left distal femurs for three distinct regions of interest.
Results
Five residents had a fracture that occurred during the study period; this represented a fracture rate of 2.1% per year in the study group. Longitudinally, annualized change in the median BMD was 0.7% to 1.0% per year in the different regions of the distal femur, but ranged widely among the study group, with both increases and decreases in BMD. Increase in BMD over time was negatively correlated with age and positively correlated with change in weight.
Interpretation
Changes in BMD over time in profoundly involved persons with CP can range widely, which is important to recognize when evaluating potential interventions to improve BMD. Age and changes in body weight appear the most relevant factors.
What this paper adds
In a cohort of patients with severe cerebral palsy, median change in bone mineral density (BMD) was less than previously described.
Age was negatively correlated with mean annualized percentage change in BMD.
Weight was positively correlated with BMD.
Change in weight was positively correlated with change in BMD.</description><identifier>ISSN: 0012-1622</identifier><identifier>EISSN: 1469-8749</identifier><identifier>DOI: 10.1111/dmcn.12790</identifier><identifier>PMID: 25951240</identifier><language>eng</language><publisher>England</publisher><subject>Absorptiometry, Photon ; Adolescent ; Adult ; Bone Density - physiology ; Cerebral Palsy - physiopathology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Long-Term Care - statistics & numerical data ; Longitudinal Studies ; Male ; Risk Factors ; Young Adult</subject><ispartof>Developmental medicine and child neurology, 2015-11, Vol.57 (11), p.1064-1069</ispartof><rights>2015 Mac Keith Press</rights><rights>2015 Mac Keith Press.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4350-cd01bd30d85b32147cf0d4bd656637f51a5184a779abfcc3bcf64475a265290a3</citedby><cites>FETCH-LOGICAL-c4350-cd01bd30d85b32147cf0d4bd656637f51a5184a779abfcc3bcf64475a265290a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdmcn.12790$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdmcn.12790$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25951240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grossberg, Richard</creatorcontrib><creatorcontrib>Blackford, Martha G</creatorcontrib><creatorcontrib>Kecskemethy, Heidi H</creatorcontrib><creatorcontrib>Henderson, Richard</creatorcontrib><creatorcontrib>Reed, Michael D</creatorcontrib><title>Longitudinal assessment of bone growth and development in a facility‐based population of young adults with cerebral palsy</title><title>Developmental medicine and child neurology</title><addtitle>Dev Med Child Neurol</addtitle><description>Aim
Osteoporosis is a significant clinical problem in persons with moderate to severe cerebral palsy (CP), causing fractures with minimal trauma. Over the past decade, most studies examining osteoporosis and CP have been cross‐sectional in nature, focused exclusively on children and adolescents and only involving one evaluation of bone mineral density (BMD). The purpose of this study was to assess BMD in a group including adults with CP, and changes in each individual's BMD over a 5‐ to 6‐year period.
Method
The study group included 40 residents of a long‐term care facility aged 6 to 26 years at the time of their initial evaluation. Twenty‐one patients (52.5%) were male, 35 (88%) were white, and 38 (95%) were in Gross Motor Function Classification System level V. BMD was assessed by dual‐energy X‐ray absorptiometry on the right and left distal femurs for three distinct regions of interest.
Results
Five residents had a fracture that occurred during the study period; this represented a fracture rate of 2.1% per year in the study group. Longitudinally, annualized change in the median BMD was 0.7% to 1.0% per year in the different regions of the distal femur, but ranged widely among the study group, with both increases and decreases in BMD. Increase in BMD over time was negatively correlated with age and positively correlated with change in weight.
Interpretation
Changes in BMD over time in profoundly involved persons with CP can range widely, which is important to recognize when evaluating potential interventions to improve BMD. Age and changes in body weight appear the most relevant factors.
What this paper adds
In a cohort of patients with severe cerebral palsy, median change in bone mineral density (BMD) was less than previously described.
Age was negatively correlated with mean annualized percentage change in BMD.
Weight was positively correlated with BMD.
Change in weight was positively correlated with change in BMD.</description><subject>Absorptiometry, Photon</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Bone Density - physiology</subject><subject>Cerebral Palsy - physiopathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Long-Term Care - statistics & numerical data</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>0012-1622</issn><issn>1469-8749</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUhi0EglJYeADkGSnFdmynGVG5SgUWmCNfi1FiR3FCFbHwCDwjT0LaACNn-Yfznf9IHwAnGM3wMOe6Un6GSZajHTDBlOfJPKP5LpgghEmCOSEH4DDGV4RQyhndBweE5QwTiibgfRn8yrWddl6UUMRoYqyMb2GwUAZv4KoJ6_YFCq-hNm-mDPV27TwU0ArlStf2Xx-fUkSjYR3qrhStC35z34fOr6DQXdlGuHZDizKNkc3wqBZl7I_Anh3SHP_kFDxfXz0tbpPl483d4mKZKJoylCiNsNQp0nMmU4JppizSVGrOOE8zy7BgeE5FluVCWqVSqSynNGOCcEZyJNIpOBt7VRNibIwt6sZVoukLjIqNwWJjsNgaHODTEa47WRn9h_4qGwA8AmtXmv6fquLyfvEwln4DvJJ_PQ</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Grossberg, Richard</creator><creator>Blackford, Martha G</creator><creator>Kecskemethy, Heidi H</creator><creator>Henderson, Richard</creator><creator>Reed, Michael D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201511</creationdate><title>Longitudinal assessment of bone growth and development in a facility‐based population of young adults with cerebral palsy</title><author>Grossberg, Richard ; Blackford, Martha G ; Kecskemethy, Heidi H ; Henderson, Richard ; Reed, Michael D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4350-cd01bd30d85b32147cf0d4bd656637f51a5184a779abfcc3bcf64475a265290a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Absorptiometry, Photon</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Bone Density - physiology</topic><topic>Cerebral Palsy - physiopathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Long-Term Care - statistics & numerical data</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Risk Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grossberg, Richard</creatorcontrib><creatorcontrib>Blackford, Martha G</creatorcontrib><creatorcontrib>Kecskemethy, Heidi H</creatorcontrib><creatorcontrib>Henderson, Richard</creatorcontrib><creatorcontrib>Reed, Michael D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Developmental medicine and child neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grossberg, Richard</au><au>Blackford, Martha G</au><au>Kecskemethy, Heidi H</au><au>Henderson, Richard</au><au>Reed, Michael D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal assessment of bone growth and development in a facility‐based population of young adults with cerebral palsy</atitle><jtitle>Developmental medicine and child neurology</jtitle><addtitle>Dev Med Child Neurol</addtitle><date>2015-11</date><risdate>2015</risdate><volume>57</volume><issue>11</issue><spage>1064</spage><epage>1069</epage><pages>1064-1069</pages><issn>0012-1622</issn><eissn>1469-8749</eissn><abstract>Aim
Osteoporosis is a significant clinical problem in persons with moderate to severe cerebral palsy (CP), causing fractures with minimal trauma. Over the past decade, most studies examining osteoporosis and CP have been cross‐sectional in nature, focused exclusively on children and adolescents and only involving one evaluation of bone mineral density (BMD). The purpose of this study was to assess BMD in a group including adults with CP, and changes in each individual's BMD over a 5‐ to 6‐year period.
Method
The study group included 40 residents of a long‐term care facility aged 6 to 26 years at the time of their initial evaluation. Twenty‐one patients (52.5%) were male, 35 (88%) were white, and 38 (95%) were in Gross Motor Function Classification System level V. BMD was assessed by dual‐energy X‐ray absorptiometry on the right and left distal femurs for three distinct regions of interest.
Results
Five residents had a fracture that occurred during the study period; this represented a fracture rate of 2.1% per year in the study group. Longitudinally, annualized change in the median BMD was 0.7% to 1.0% per year in the different regions of the distal femur, but ranged widely among the study group, with both increases and decreases in BMD. Increase in BMD over time was negatively correlated with age and positively correlated with change in weight.
Interpretation
Changes in BMD over time in profoundly involved persons with CP can range widely, which is important to recognize when evaluating potential interventions to improve BMD. Age and changes in body weight appear the most relevant factors.
What this paper adds
In a cohort of patients with severe cerebral palsy, median change in bone mineral density (BMD) was less than previously described.
Age was negatively correlated with mean annualized percentage change in BMD.
Weight was positively correlated with BMD.
Change in weight was positively correlated with change in BMD.</abstract><cop>England</cop><pmid>25951240</pmid><doi>10.1111/dmcn.12790</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1622 |
| ispartof | Developmental medicine and child neurology, 2015-11, Vol.57 (11), p.1064-1069 |
| issn | 0012-1622 1469-8749 |
| language | eng |
| recordid | cdi_crossref_primary_10_1111_dmcn_12790 |
| source | MEDLINE; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Absorptiometry, Photon Adolescent Adult Bone Density - physiology Cerebral Palsy - physiopathology Child Child, Preschool Cross-Sectional Studies Female Humans Long-Term Care - statistics & numerical data Longitudinal Studies Male Risk Factors Young Adult |
| title | Longitudinal assessment of bone growth and development in a facility‐based population of young adults with cerebral palsy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T23%3A55%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Longitudinal%20assessment%20of%20bone%20growth%20and%20development%20in%20a%20facility%E2%80%90based%20population%20of%20young%20adults%20with%20cerebral%20palsy&rft.jtitle=Developmental%20medicine%20and%20child%20neurology&rft.au=Grossberg,%20Richard&rft.date=2015-11&rft.volume=57&rft.issue=11&rft.spage=1064&rft.epage=1069&rft.pages=1064-1069&rft.issn=0012-1622&rft.eissn=1469-8749&rft_id=info:doi/10.1111/dmcn.12790&rft_dat=%3Cwiley_cross%3EDMCN12790%3C/wiley_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/25951240&rfr_iscdi=true |