An in vivo drug screen in zebrafish reveals that cyclooxygenase 2-derived prostaglandin D 2 promotes spinal cord neurogenesis

The study of neurogenesis is essential to understanding fundamental developmental processes and for the development of cell replacement therapies for central nervous system disorders. Here, we designed an in vivo drug screening protocol in developing zebrafish to find new molecules and signalling pa...

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Veröffentlicht in:	Cell proliferation 2024-05, Vol.57 (5), p.e13594
Hauptverfasser:	González-Llera, Laura, Sobrido-Cameán, Daniel, Quelle-Regaldie, Ana, Sánchez, Laura, Barreiro-Iglesias, Antón
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase Inhibitors - pharmacology Drug Evaluation, Preclinical - methods Neurogenesis - drug effects Signal Transduction - drug effects Spinal Cord - cytology Spinal Cord - drug effects Spinal Cord - metabolism Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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