Inhibition of Acetylcholinesterase (AChE): A Potential Therapeutic Target to Treat Alzheimer's Disease

A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. Most of the tested compounds exhibited high AChE inhibition and low toxicity, and among which compounds 1, 2, and 10 were the most potent (IC50 = 71.52 ± 22.43, 8.28...

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Veröffentlicht in:	Chemical biology & drug design 2015-10, Vol.86 (4), p.776-782
Hauptverfasser:	Li, Yong, Zhang, Xiao-xiao, Jiang, Li-juan, Yuan, Li, Cao, Ting-ting, Li, Xia, Dong, Lin, Li, Ying, Yin, Shu-Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - chemistry Acetylcholinesterase - metabolism AChE inhibition Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer's disease Cell Line Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology derivatives Drug Design Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Epimedium - chemistry Flavonoids - chemistry Flavonoids - pharmacology Humans icariin Structure-Activity Relationship synthesis
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